Expression of the thymidine phosphorylase gene in epithelial ovarian cancer

British Journal of Cancer

Volumn 79, Issue 11-12, 1999, Pages 1848-1854

  Hata, K ^a   Kamikawa, T ^b   Arao, S ^c   Tashiro, H ^c   Katabuchi, H ^c   Okamura, H ^c   Fujiwaki, R ^a   Miyazaki, K ^a   Fukumoto, M ^d  

^a SHIMANE UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c School of Medicine   (Japan)

^d TOHOKU UNIVERSITY   (Japan)

Author keywords

Epithelial ovarian cancer; Gene expression; Reverse transcriptase polymerase chain reaction; Thymidine phosphorylase

Indexed keywords

BETA 2 MICROGLOBULIN; THYMIDINE PHOSPHORYLASE;

ADULT; AGED; ARTICLE; FEMALE; FOLLOW UP; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; OVARY CANCER; PRIORITY JOURNAL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0033063734     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690294     Document Type: Article

References (32)

1. Arao S, Suwa H, Mandai M, Tashiro H, Miyazaki K, Okamura H, Nomura H, Hiai H and Fukumoto M (1994) Expression of multidrug resistance gene and localization of P-glycoprotein in human primary ovarian cancer. Cancer Res 54: 1355-1359
2. Bourne TH, Campbell S, Reynolds KM, Whitehead MI, Hampson J, Royston P, Crayford TJB and Collins WP (1993) Screening for early familial ovarian cancer with transvaginal ultrasonography and colour blood flow imaging. Br J Med 306: 1025-1029
3. Cannistra A.S. (1993) Cancer of the ovary. N Engl J Med 329: 1550-1559
4. Cox DR (1972) Regression models and life tables. J R Stat Soc B 31: 1333-1335
5. Eisenstein BI (1990) The polymerase chain reaction: a new method of using molecular genetics for medical diagnosis. N Engl J Med 322: 181-183
6. Fox SB, Westwood M, Moghaddam A, Comley M, Turley H, Whitehouse RM, Bicknell R, Gatter KC and Harris AL (1996) The angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase is up-regulated in breast cancer epithelium and endothelium. Br J Cancer 73: 275-280
7. Furukawa T, Yoshimura A, Sumizawa T, Haraguchi M, Akiyama S, Fukui K, Ishizawa M and Yamada Y (1992) Angiogenic factor. Nature, 356: 668
8. Giatromanolaki A, Koukourakis MI, Comley M, Kaklamanis L, Turley H, O'Byrne K, Harris AL and Gatter KC (1997) Platelet-derived endothelial cell growth factor (thymidine phosphorylase) expression in lung cancer. J Pathol 181: 196-199
9. Griffiths CT and Parker L (1986) Cancer of the ovary. In Gynaecologic Oncology. Knapp RC and Berkowitz RS (ed), pp. 313-375. Macmillan: New York
10. Hagiwara K, Stenman G, Honda H, Sahlin P, Andersson A, Miyazono K, Heldin C-H, Ishikawa F and Takaku F (1991) Organization and chromosomal localization of the human platelet-derived endothelial cell growth factor gene. Mol Cell Biol 11: 2125-2132
11. Haraguchi M, Miyadera K, Uemura K, Sumizawa T, Furukawa T, Yamada K, Akiyama S and Yamada Y (1994) Angiogenic activity of enzymes. Nature 368: 198
12. Hata K, Hata T and Kitao M (1995) Intratumoral peak systolic velocity as a new possible predictor for detection of adnexal malignancy. Am J Obstet Gynecol 172: 1496-1500
13. Hata K, Hata T and Collins WP (1997) Association of thymidine phosphorylase concentration with ultrasound-derived indices of blood flow in ovarian masses. Cancer 80: 1079-1084
14. International Federation of Gynecology and Obstetrics (FIGO) (1987) Changes in definitions of clinical staging for carcinoma of the cervix and ovary. Am J Obstet Gynecol 156: 263-264
15. Ishikawa F, Miyadera K, Hellman U, Drexler H, Hagiwara K, Usuki K, Takaku F, Risau W and Heldin CH (1989) Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature 338: 557-562
16. Kono A, Hara Y, Sugata S, Karube Y, Matsushima Y and Ishitsuka H (1983) Activation of 5′-deoxy-5-fluorouridine by thymidine phosphorylase in human tumors. Chem Pharma Bull 31: 175-178
17. Kosary CL (1994) FIGO stage, histologic grade, age, and race as prognostic factors in determining survival for cancers of the female gynecological system: an analysis of 1973-87 SEER cases of cancers of the endometrium, cervix, ovary, vulva and vagina. Semin Surg Oncol 10: 31-46
18. Kumagai K, Yasui A, Nishida Y, Masuo K and Yoshitoshi A (1993) The significance of preoperative chemotherapy for early gastric carcinoma. Surgery Today 23: 875-879
19. Maeda K, Chung Y-S, Ogawa Y, Takatsuka T, Kang S-M, Ogawa M, Sawada T and Onoda N (1996) Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma. Br J Cancer 73: 884-888
20. Mimori K, Mori M, Shiraishi T, Haraguchi M, Ueo H and Akiyoshi T (1997) Clinical significance of pyrimidine nucleoside phosphorylase in colorectal cancer. Int J Oncol 10: 493-496
21. Miyadera K, Sumizawa T, Haraguchi M, Yoshida H, Konstanty W, Yanada Y and Akiyama Y (1995) Role of thymidine phosphorylase activity in the angiogenic effect of platelet-derived endothelial cell growth factor/thymidine phosphorylase. Cancer Res 55: 1687-1690
22. Moghaddam A and Bicknell R (1992) Expression of platelet-derived endothelial cell growth factor in Escherichia coli and confirmation of its thymidine phosphorylase activity. Biochemistry 31: 12141-12146
23. O'Brien TS, Fox SB, Dickinson AJ, Turley H, Westwood M, Moghaddam A, Gatter KC, Bicknell R and Harris AL (1996) Expression of the angiogenic factor thymidine phosphorylase/platelet derived endothelial cell growth factor in primary bladder cancers. Cancer Res 56: 4799-4804
24. Patterson AV, Zhang H, Moghaddam A, Bickell R, Talbot DC, Stratford IJ and Harris AL (1995) Increased sensitivity to the prodrug 5′-deoxy-5-fluorouridine and modulation of 5-fluoro-2′-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase. Br J Cancer 72: 699-675
25. Pauly JL, Schuller MG, Zelcer AA, Kriss TA, Gore SS and Germain MJ (1997) Identification and comparative analysis of thymidine phosphorylase in the plasma of healthy subjects and cancer patients. J Natl Cancer Inst 58: 1587-1590
26. Reynolds K, Farzaneh F, Collins WP, Campbell S, Bourne TH, Lawton F, Moghaddam A, Harris AL and Bickell R (1994) Association of ovarian malignancy with expression of platelet-derived endothelial cell growth factor. J Natl Cancer Inst 86: 1234-1238
27. Scholl SM, Bascou CH, Mosseri V, Olivares R, Magdelenat H, Dorval T, Palangie T, Validire P, Pouillart P and Stanley ER (1994) Circulating levels of colony-stimulating factor I as a prognostic indicator in 82 patients with epithelial ovarian cancer. Br J Cancer 69: 342-346
28. Szepeshazi K, Lapis K and Scally V (1991) Effect of combination treatment with analogs of luteinizing hormone-releasing hormone (LH-RH) or somatostatin and 5-fluorouracil on pancreatic in hamsters. Int J Cancer 49: 260-266
29. Takebayashi Y, Akiyama S, Akiba S, Yamada K, Miyadera K, Sumizawa T, Yamada Y, Murata F and Aikou T (1996) Clinicopathologie and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma. J Natl Cancer Inst 88: 1110-1117
30. Takebayashi Y, Akiyama S, Tani A, Haraguchi M, Furukawa T, Miyadera K, Yamada Y and Aikou T (1997) Induction of thymidine phosphorylase by hypoxia and relationship between expression of thymidine phosphorylase and apoptosis. Proc Annu Am Assoc Cancer Res 38: 48
31. Yoshimura A, Kuwazuru Y, Furukawa T, Yoshida H, Yamada K and Akiyama S (1990) Purification and tissue distribution of human thymidine phosphorylase: high expression in lymphocytes, reticulocytes and tumors. Biochim Biophys Acta 1034: 107-113
32. Zimmerman M and Seidenberg J (1964) Deoxyribosyl transfer. Thymidine phosphorylase and nucleoside deoxyribosyltransferase in normal and malignant tissue. J Biol Chem 230: 2618-2621