Comparison of buspirone with diazepam and fluvoxamine on aversive classical conditioning in humans

Journal of Psychopharmacology

Volumn 13, Issue 2, 1999, Pages 122-127

  Hellewell, J S E ^a   Guimaraes, F S ^b   Wang, M ^c   Deakin, J F W ^d  

^a TRAFFORD GENERAL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF HULL   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

5 HT; Antidepressant; Anxiety; Conditioning; Human; Psychophysiology

Indexed keywords

ANXIOLYTIC AGENT; BUSPIRONE; DIAZEPAM; FLUVOXAMINE; SEROTONIN 1A RECEPTOR;

ADULT; ANXIETY; ARTICLE; AVERSION; CELL ACTIVITY; CLINICAL TRIAL; CONDITIONING; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; ELECTRODERMAL RESPONSE; FEMALE; HABITUATION; HUMAN; HUMAN EXPERIMENT; MALE; MEDIAN RAPHE NUCLEUS; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEROTONINERGIC NERVE CELL; WHITE NOISE;

EID: 0033063327     PISSN: 02698811     EISSN: None     Source Type: Journal    
DOI: 10.1177/026988119901300202     Document Type: Article

References (37)

1. Adell A, Artigas F (1991) Differential effects of clomipramine given locally or systematically on extracellular 5-hydroxytryptamine in raphe nuclei and frontal cortex. Arch Pharmacol 342: 237-244
2. Anderson I M, Parry-Billings M, Newsholme E A, Fairburn C G, Cowen PJ (1990) Dieting reduces plasma tryptophan and alters brain 5-HT function in women Psychol Med 20: 785-791
3. Ashcroft K, Guimaraes F S, Wang M, Deakin J F W (1991) Evaluation of a psychophysiological model of classical fear conditioned in anxious patients. Psychopharmacology 104: 215-219
4. Azmitea E C, Segal M (1978) An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J Neurol 179: 641-668
5. Beninger R J, Phillips A G (1979) Possible involvement of serotonin in extinction. Pharmacol Biochem Behav 10: 37-41
6. 1 receptor agonists to p-chloroamphetamine. Synapse 5: 120-133
7. Chopin P, Briley M (1987) Models of anxiety: the effect of compounds that modify 5-HT. TIPS 8: 383-387
8. Connell J, Hellewell J S E, Deakin J F W (1994) Effects of a 5HT-2C agonist in two models of anxiety in volunteers. J Psychopharmacol A23
9. Deakin J F W (1983) Roles of serotonergic systems in escape, avoidance and other behaviours. In Cooper S J (ed.), Theory in psychopharmacology, Vol. 2. Academic Press, New York, pp. 149-193
10. Deakin J F W (1988) 5HT2 receptors, depression and anxiety. Pharmacol Biochem Behav 29: 819-820
11. Deakin J F W (1996) 5HT, antidepressant drugs and the psychosocial origins of depression. J Psychopharmacol 10: 31-38
12. Deakin J F W, Graeff F G (1991) 5HT and mechanisms of defence. J Psychopharmacol 5: 305-315
13. Deakin J F W, Graeff F, Guimaraes F S (1992) 5HT receptor subtypes and the modulation of aversion. In Marsden C A, Heal D J (eds), Central serotonin receptors and psychotropic drugs. Blackwell Scientific Publications, Oxford, pp. 147-174
14. Eysenck H J (1979) The conditioning model of neurosis. Behav Brain Sci 2: 155-199
15. Eysenck H J, Eysenck S B G (1991) Manual of the Eysenck Personality Scales (EPS adult). Hodder & Stoughton, London
16. File S E (1987) The search for novel anxiolytics.TINS 10: 461-463
17. 1A receptor antagonist and an SSRI in vivo: effects on 5-HT cell firing and extracellular 5-HT. Br J Pharmacol 115: 1064-1070
18. Goa K L, Ward A (1986) Buspirone, a preliminary review of its pharmacological properties and therapeutic efficacy as an anxiolytic. Drugs 32: 114-129
19. Gomez E, Connell J, Hellewell J S E, Deakin J F W (1995) Effects of a selective 5HT2A antagonist in two models of anxiety and higher cognitive functions in healthy volunteers. J Psychopharmacol 9: 59
20. Goodwin G M, Murray C L, Bancroft J (1994) Oral d-fenfluramine and neuroendocrine challenge: problems with the 30 mg dose in man. J Affect Disord 30: 117-122
21. Grasby P M, Friston K J, Bench C, Cowen P J, Frith C D, Liddle P F, Frackowiak R S, Dolan R J (1992) Effect of the 5HT1A partial agonist buspirone on regional cerebral blood flow in man. Psychopharmacology 108: 380-386
22. Gray J A (1987) The psychology of fear and stress, 2nd edn. Cambridge University Press, Cambridge
23. Guimaraes F S, Hellewell J, Hensman R, Wang M, Deakin J F W (1991) Characterization of a psychophysiological model of classical fear conditioning in healthy volunteers: influence of gender, instruction, personality and placebo. Psychopharmacol 104: 231-236
24. Hensman R, Guimaraes F S, Wang M, Deakin J F W (1991) The effects of ritanserin on aversive classical conditioning in humans. Psychopharmacology 104: 220-224
25. Hetem L A, de Sousza C J, Guimaraes F S, Zuardi A W, Graeff F G (1996) Effect of d-fenfluramine on human experimental anxiety. Psychopharmacology 127: 276-282
26. Jennen-Steinmetz C (1989) Synopsis of repeated measurement analysis. J Psychophysiol 3: 193-194
27. Jensen H H, Hutchings B, Poulsen J C (1989) Conditioned emotional responding under diazepam: a psychophysiological study of the state-dependent learning. Psychopharmacology 98: 312-397
28. Lista A, Blier P, de Montigny C (1989) In vivo presynaptic modulation of serotonergic neurotransmission in the rat hippocampus by diazepam. Eur J Pharmacol 171: 229-231
29. Lorden J F, Rickert E J, Berry D W (1983) Forebrain monoamines and associative learning: I. latent inhibition and conditioned inhibition. Behav Brain Res 9: 181-199
30. Medical Research Council (1965) Report by Clinical Psychiatry Committee-clinical trial of the treatment of depressive illness, BMJ 1: 881-886
31. Norusis M J (1988) SPSS/PC+ advanced statistics, V2.0. SPSS, Chicago
32. O'Connor J J, Rowan M J, Anwyl R (1990) Actions of 5-HT1 ligands on excitatory synaptic transmission in the hippocampus of alert rats. Br J Pharmacol 101: 171-177
33. Pazos A, Palacios J M (1985) Quantitative autoradiographic mapping of serotonin receptors in rat brain. I. serotonin-1 receptors. Brain Res 346: 205-230
34. Solomon P R, Kiney C A, Scott D R (1978) Disruption of latent inhibition following systemic administration of parachlorophenylalanine (PCPA). Physiol Behav 20: 265-271
35. Spielberger C D, Gorsuch R I, Lushene R E (1970) Manual for the state-trait anxiety inventory (self-evaluation questionnaire). Consulting Psychologists Press, Palo Alto
36. Venables P H, Christie M J (1980) Electrodermal activity. In Martin I, Venables P H (eds), Techniques in psychophysiology. John Wiley & Sons, Chichester, pp. 3-68
37. Walsh A E, Oldman, Franklin C G, Fairburn C G, Cowen P J (1995) Dieting decreases plasma tryptophan and increases the prolactin response to d-fenfluramine in healthy women but not men. J Affect Disord 33: 89-97