The percutaneous penetration of prostaglandin E1 and its alkyl esters

Journal of Controlled Release

Volumn 58, Issue 3, 1999, Pages 349-355

  Ho, Hsiu O ^a   Hwang, Ming Chun ^a   Tseng, Shu Ling ^a   Lin, Lun Huei ^a   Chen, Kuo Tung ^a   Chiang, Han Sun ^a   Spur, Brend W ^b   Wong, Patrick Y K ^b   Sheu, Ming Thau ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b UMDNJ School of Osteopathic Medicine   (United States)

Author keywords

Alkyl ester; Cosolvent; Penetration; Prostaglandin E1

Indexed keywords

PROSTAGLANDIN E1; PROSTAGLANDIN E1 DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SKIN PENETRATION;

ALPROSTADIL; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESTERS; ETHANOL; MICE; MICE, INBRED HRS; PROSTAGLANDINS B; SKIN ABSORPTION; SOLUBILITY; TIME FACTORS;

EID: 0033063113     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(98)00169-2     Document Type: Article

References (19)

1. H. Wendel, F.J. Braun, Transdermal prostaglandin composition, US Patent (1995) 5,380,760.
2. Watkinson A.C., Hadgraft J., Bye A. Aspects of the transdermal delivery of prostaglandins. Int. J. Pharm. 74:1991;229-236.
3. Watkinson A.C., Bye A., Hadgraft J. Aspects of the transdermal delivery of prostaglandins II. Int. J. Pharm. 83:1992;171-175.
4. 1 in fatty alcohol propylene glycol ointment by acidic cyclodextrin derivative O-carboxymethyl-ethyl-β-cyclodextrin. Chem. Pharm. Bull. 40:1992;1586-1591.
5. 1 in hairless mice. Eur. J. Pharm. Sci. 1:1993;117-123.
6. 1 derivatives as pharmaceutically active agents, and pharmaceutical compositions containing these compounds, especially for transcutaneous administration US Patent (1993) 5,219,885.
7. 1 and its ethyl ester, J. Control. Release (1998) in press.
8. 3 in frog tissue. J. Charmatogr. 394:1987;353-362.
9. 2. J. Pharm. Sci. 62:1973;576-580.
10. 2) under strongly acidic and basic conditions. J. Pharm. Sci. 66:1977;1590-1595.
11. Andersen N.H. Dehydration of prostaglandins: study by spectroscopic method. J. Lipid Res. 10:1969;320-325.
12. 1 in a lipid emulsion. Pharm. Res. 6(3):1989;210-215.
13. 1 ethylester, J. Chin. Pharm. (1998) in press.
14. Fedor R.F. A method for estimating both the solubility parameters and molar volumes of liquids. Polym. Eng. Sci. 14:1974;147-154.
15. A.F.M. Barton, Handbook of Solubility Parameters and other Cohesion Parameters, CRC Press, Boca Raton, FL, 1983.
16. Sloan K.B., Koch S.A., Silver K.G., Flowers F.P. Use of solubility parameters of drug and vehicle to predict flux through skin. J. Invest. Dermatol. 87:1986;244-252.
17. Liu C.H., Ho H.O., Hsieh M.C., Sokoloski T.D., Sheu M.T. Studies on the in-vitro percutaneous penetration of indomethacin from gel systems in hairless mice. J. Pharm. Pharmacol. 47:1995;365-372.
18. Bucks D.A.W. Skin structure and metabolism: relevance to design of cutaneous therapeutics. Pharm. Res. 2(1):1984;148-153.
19. Liu P., Higuchi W.I., Ghanem A.-H., Kurihara-Bergstrom T., Good W.R. Assessing the influence of ethanol on simultaneous diffusion and metabolism of β-estradiol in hairless mouse skin for the asymmetric situation in vitro. Int. J. Pharm. 78:1992;123-136.