Using genetic analyses to clarify the distinction between depressive and anxious symptoms in children

Journal of Abnormal Child Psychology

Volumn 27, Issue 2, 1999, Pages 105-114

  Eley, Thalia C ^a,c   Stevenson, Jim ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Anxiety; Comorbidity; Depression; Etiology; Twins

Indexed keywords

ADOLESCENT; ANXIETY NEUROSIS; ARTICLE; CHILD BEHAVIOR; CHILDHOOD DISEASE; COMORBIDITY; CORRELATION FUNCTION; DEPRESSION; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; ENVIRONMENTAL FACTOR; GENETIC ANALYSIS; HUMAN; MAJOR CLINICAL STUDY; PATHOPHYSIOLOGY; SCHOOL CHILD; SELF REPORT; STATISTICAL ANALYSIS; TWINS;

ADOLESCENT; ANXIETY DISORDERS; CHILD; DEPRESSIVE DISORDER; DISEASES IN TWINS; FACTOR ANALYSIS, STATISTICAL; GENETIC PREDISPOSITION TO DISEASE; HUMANS; QUESTIONNAIRES; TWINS;

EID: 0033063065     PISSN: 00910627     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021947113860     Document Type: Article

References (66)

1. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
2. Andrews, G., Stewart, G., Allen, R., & Henderson, A. S. (1990). The genetics of six neurotic disorders: A twin study. Journal of Affective Disorders, 19, 23-29.
3. Ball, D., Hill, L., Freeman, B., Eley, T. C., Strelau, J., Riemann, R., Spinath, F. M., Angleitner, A., & Plomin, R. (1997). The serotonin transporter gene and peer-rated neuroticism. NeuroReport, 8, 1301-1304.
4. Biederman, J., Rosenbaum, J. F., Bolduc, E. A., Faraone, S. V., & Hirshfeld, D. R. (1991). A high risk study of young children of parents with panic disorder and agoraphobia with and without comorbid major depression. Psychiatry Research, 37, 333-348.
5. Brady, E. U., & Kendall, P. C. (1992). Comorbidity of anxiety in children and adolescents. Psychological Bulletin, 111, 244-255.
6. Brown, S. L., Svrakic, D. M., Przybeck, T. R., & Cloninger, C. R. (1992). The relationship of personality to mood and anxiety states: A dimensional approach. Journal of Psychiatric Research, 26, 197-211.
7. Caron, C., & Rutter, M. (1991). Comorbidity in child psychopathology: Concepts, issues and research strategies. Journal of Child Psychology and Psychiatry, 32, 1063-1080.
8. Clark, L. A. (1989). The anxiety and depressive disorders: Descriptive psychopathology and differential diagnosis. In P. C. Kendall & D. Watson (Eds.), Anxiety and depression: Distinctive and overlapping features (pp. 83-129). San Diego, CA: Academic Press.
9. Clark, L. A., & Watson, D. (1991). Tripartite model of anxiety and depression: Psychometric evidence and taxonomic implications. Journal of Abnormal Psychology, 100, 316-336.
10. Cloninger, C. R. (1986). A unified biosocial theory of personality and its role in the development of anxiety states. Psychiatric Developments, 3, 167-226.
11. Cohen, D. J., Dibble, E., Grawe, J. M., & Pollin, W. (1973). Separating identical from fraternal twins. Archives of General Psychiatry, 29, 465-469.
12. Collier, D. A., Arranz, M. J., Sham, P., Battersby, S., Vallada, H. P., Gill, P., Aitchison, K. J., Sodhi, M., Li, T., Roberts, G. W., Smith, B., Morton, J., Murray, R. M., Smith, D., & Kirov, G. (1996). The serotonin transporter is a potential susceptibility factor for bipolar affective disorder. NeuroReport, 7, 1675-1679.
13. Costello, A., & Angold, A. (1988). Scales to assess child and adolescent depression: Checklists, screens, and nets. Journal of the American Academy of Child and Adolescent Psychiatry, 27, 726-737.
14. Crowley, S. L., & Emerson, E. N. (1996). Discriminant validity of self-reported anxiety and depression in children: Negative affectivity or independent constructs? Journal of Clinical Child Psychology, 25, 139-146.
15. Eaves, L. J., Eysenck, H., & Martin, N. G. (1989). Genes, culture, and personality: An empirical approach. London: Academic Press.
16. Eaves, L. J., Silberg, J. L., Meyer, J. M., Maes, H. H., Simonoff, E., Pickles, A., Rutter, M., Neale, M. C., Reynolds, C. A., Erickson, M. T., Heath, A. C., Loeber, R., Truett, K. R., & Hewitt, J. K. (1997). Genetics and developmental psychopathology: 2. The main effects of genes and environment on behavioral problems in the Virginia Twin Study of Adolescent Behavioral Development. Journal of Child Psychology and Psychiatry, 38, 965-980.
17. Eley, T. C. (1996). The aetiology of emotional symptoms in children and adolescents: Depression and anxiety in twins. Unpublished, Ph.D. thesis, University of London.
18. Eley, T. C. (1997). Depressive symptoms in children and adolescents: Etiological links between normality and abnormality. A research note. Journal of Child Psychology and Psychiatry, 38, 861-866.
19. Eley, T. C., & Stevenson, J. (1998a). Specific life events and chronic experiences differentially associated with depression and anxiety in young twins. Manuscript submitted for publication.
20. Eley, T. C., & Stevenson, J. (1998b). Using genetic analyses to explore the covariation between anxiety and depression symptoms: Effects of age and sex. Manuscript submitted for publication.
21. Eysenck, H. J., & Eysenck, S. B. G. (1975). Manual of the Eysenck Personality Questionnaire. London: Hodder & Stoughton.
22. Finlay-Jones, R., & Brown, G. W. (1981). Types of stressful life events and the onset of anxiety and depressive disorders. Psychological Medicine, 11, 803-815.
23. Fundudis, T., Berney, T. P., Kolvin, I., Famuyiwa, O. O., Barrett, M. L., Bhate, S. R., & Tyrer, S. P. (1991). Reliability and validity of two self-rating scales in the assessment of childhood depression. British Journal of Psychiatry, 159, 36-40.
24. Goldsmith, H. H. (1991). A zygosity questionnaire for young twins: A research note. Behavior Genetics, 21, 257-269.
25. Goodyer, I. M., & Altham, P. M. E. (1991). Lifetime exit events and recent social and family adversities in anxious and depressed school-age children and adolescents: I. Journal of Affective Disorders, 21, 219-228.
26. Goodyer, I. M., Wright, C., & Altham, P. M. E. (1989). Recent friendships in anxious and depressed school age children. Psychological Medicine, 19, 165-174.
27. Goodyer, I. M., Wright, C., & Altham, P. M. E. (1990a). The friendships and recent life events of anxious and depressed school-age children. British Journal of Psychiatry, 156, 689-698.
28. Goodyer, I. M., Wright, C., & Altham, P. M. E. (1990b). Recent achievements and adversities in anxious and depressed school age children. Journal of Child Psychology and Psychiatry, 31, 1063-1077.
29. Heath, A. C., Cloninger, C. R., & Martin, N. G. (1994). Testing a model for the genetic structure of personality: A comparison of the personality systems of Cloninger and Eysenck. Journal of Personality and Social Psychology, 66, 762-775.
30. Hirschfeld, R. M. A., & Klerman, G. L. (1979). Personality attributes and affective disorders. American Journal of Psychiatry, 136, 67-70.
31. Jowell, R., Curtice, J., Park, A., Brook, L., Thomson, K., & Bryson, C. (1997). British Social Attitudes, the 14th report: The end of a Conservative era? Aldershot, England: Ashgate Publishing Company.
32. Kendler, K. S., Heath, A. C., Martin, N. G., & Eaves, L. J. (1987). Symptoms of anxiety and depression: Same genes, different environments? Archives of General Psychiatry, 44, 451-457.
33. Kendler, K. S., Neale, M. C., Kessler, R. C., Heath, A. C., & Eaves, L. J. (1992). Major depression and generalized anxiety disorder: Same genes, (partly) different environments? Archives of General Psychiatry, 49, 716-722.
34. Kovacs, M. (1981). The Child Depression Inventory (CDI). Psychopharmacology Bulletin, 17, 995-998.
35. Kovacs, M. (1985). The Children's Depression Inventory (CDI). Psychopharmacology Bulletin, 21, 995-1124.
36. Lesch, K. P., Bengel, D., Heils, A., Zhang Sabol, S., Greenburg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996, November). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527-1530.
37. Lichtenstein, P., & Annas, P. (1997). The heritability of specific fears and phobias in children. Behavior Genetics, 27, 598.
38. Livingston, R., Nugent, H., Rader, L., & Smith, G. R. (1985). Family histories of depressed and severely anxious children. American Journal of Psychiatry, 142, 1497-1499.
39. Loss, N., Beck, S. J., & Wallace, A. (1995). Distressed and nondistressed third- and sixth-grade children's self-reports of life events and impact and concordance with mothers. Journal of Abnormal Child Psychology, 23, 397-409.
40. Mackinnon, A. J., Henderson, A. S., & Andrews, G. (1990). Genetic and environmental determinants of the lability of trait neuroticism and the symptoms of anxiety and depression. Psychological Medicine, 20, 581-590.
41. Maser, J. D., & Cloninger, C. R. (1990). Comorbidity of mood and anxiety disorders. Washington, DC: American Psychiatric Press.
42. Mulder, R. T., Joyce, P. R., & Cloninger, C. R. (1994). Temperament and early environmental influence on comorbidity and personality disorders in major depression. Comprehensive Psychiatry, 35, 225-233.
43. Murray, K. T., & Sines, J. O. (1996). Parsing the genetic and nongenetic variance in children's depressive behavior. Journal of Affective Disorders, 38, 23-34.
44. Neale, M. C. (1997). Mx: Statistical Modelling. Box 126 MCV, Richmond, VA 23298: Department of Psychiatry.
45. Neale, M. C., & Cardon, L. R. ( 1992). Methodology for genetic studies of twins and families. Dordrecht, The Netherlands: Kluwer Academic Publications.
46. Norusis, M. J. (1990). SPSS/PC + 4.0 base manual. Chicago: SPSS Inc.
47. Norvell, N., Brophy, C., & Finch, A. J. (1985). The relationship of anxiety to childhood depression. Journal of Personality Assessment, 49, 150-153.
48. O'Connor, T. G., Neiderhiser, J. M., Reiss, D., Hetherington, E. M., & Plomin, R. (1998). Genetic contributions to continuity, change, and co-occurrence of antisocial and depressive symptoms in adolescence. Journal of Child Psychology and Psychiatry, 39, 323-336.
49. Ollendick, T. H., & Yule, W. (1990). Depression in British and American children and its relation to anxiety and fear. Journal of Consulting and Clinical Psychology, 58, 126-129.
50. Plomin, R., DeFries, J. C., McClearn, G. E., & Rutter, M. (1997). Behavioral Genetics. New York: Freeman.
51. Rende, R. D., Plomin, R., Reiss, D., & Hetherington, E. M. (1993). Genetic and environmental influences on depressive symptomatology in adolescence: Individual differences and extreme scores. Journal of Child Psychology and Psychiatry, 34, 1387-1398.
52. Reynolds, C. R., & Richmond, B. O. (1978). What I think and feel: A revised measure of children's manifest anxiety. Journal of Abnormal Psychology, 6, 271-280.
53. Reynolds, C. R., & Richmond, B. O. (1979). Factor structure and construct validity of "What I Think and Feel": The Revised Children's Manifest Anxiety Scale. Journal of Personality Assessment, 43, 281-283.
54. Reynolds, W. M. (1989). Reynolds Child Depression Scale. Odessa, FL: Psychological Assessments Resource Inc.
55. Roy, M. A., Neale, M. C., Pedersen, N. L., Mathe, A. A., & Kendler, K. S. (1995). A twin study of generalized anxiety disorder and major depression. Psychological Medicine, 25, 1037-1049.
56. Spielberger, C. (1973). Preliminary test manual for the State-Trait Anxiety Inventory for Children. Palo Alto, CA: Consulting Psychologists Press.
57. Stevenson, J., Batten, N., & Cherner, M. (1992). Fears and fearfulness in children and adolescents: A genetic analysis of twin data. Journal of Child Psychology and Psychiatry, 33, 977-985.
58. Thapar, A., & McGuffin, P. (1994). A twin study of depressive symptoms in childhood. British Journal of Psychiatry, 165, 259-265.
59. Thapar, A., & McGuffin, P. (1995). Are anxiety symptoms in childhood heritable? Journal of Child Psychology and Psychiatry, 36, 439-447.
60. Thapar, A., & McGuffin, P. (1997). Anxiety and depressive symptoms in childhood: A genetic study of comorbidity. Journal of Child Psychology and Psychiatry, 38, 651-656.
61. Tisher, M., Tonge, B. J., & Home, D. J. (1994). Childhood depression, stressors and parental depression. Australian and New Zealand Journal of Psychiatry, 28, 635-641.
62. Topolski, T. D., Hewitt, J. K., Eaves, L. J., Silberg, J. L., Meyer, J. M., Rutter, M., Pickles, A., & Simonoff, E. (1997). Genetic and environmental influences on child reports of manifest anxiety and symptoms of separation anxiety and overanxious disorders: A community-based twin study. Behavior Genetics, 27, 15-28.
63. Watson, D., Clark, L. A., Weber, K., Smith Assenheimer, J., Strauss, M. E., & McCormick, R. A. (1995a). Testing a tripartite model: I. Evaluating the convergent and discriminant validity of anxiety and depression symptom scales. Journal of Abnormal Psychology, 104, 3-14.
64. Watson, D., Clark, L. A., Weber, K., Smith Assenheimer, J., Strauss, M. E., & McCormick, R. A. (1995b). Testing a tripartite model: II. Exploring the symptom structure of anxiety and depression in student, adult, and patient samples. Journal of Abnormal Psychology, 104, 15-25.
65. Weissman, M. M., Leckman, J. F., Merikangas, K. R., Gammon, G. D., & Prusoff, B. A. (1984). Depression and anxiety disorders in parents and children: Results from the Yale Family Study. Archives of General Psychiatry, 41, 845-852.
66. Williams, L. J., & Holahan, P. J. (1994). Parsimony-based fit indices for multiple-indicator models: Do they work? Structural Equation Modelling, 1, 161-189.