Depression comorbid with physical illness

Current Opinion in Psychiatry

Volumn 12, Issue 1, 1999, Pages 87-92

  Parker, Gordon ^a,b   Kalucy, Megan ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b PRINCE OF WALES HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOXETINE; NORTRIPTYLINE; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

COMORBIDITY; DEPRESSION; DIABETES MELLITUS; HEART DISEASE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NEUROLOGIC DISEASE; PHYSICAL DISEASE; PREVALENCE; REVIEW; RISK FACTOR;

EID: 0033062693     PISSN: 09517367     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001504-199901000-00023     Document Type: Review

References (29)

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18. A model paper that will be of great assistance to researchers by both identifying a broad set of methodological problems and informing readers about practical strategies for overcoming a number of intrinsic limitations to studying depression in poststroke samples. Many of the problems outlined can be extrapolated to other neurological conditions and, in fact, to other subpopulations of the medically ill
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25. Goodnick PJ. Diabetes mellitus and depression: issues in theory and treatment. Psychiatr Ann 1997; 27:353-359. Pre-existing depression is associated with an increased risk of developing diabetes, and comorbid depression is associated with poorer diabetic control. The nature of the association is unclear but may have a biochemical basis. TCAs are associated with worsening diabetes control because of their predominant influence on noradrenaline, whereas the SSRIs are associated with significant reductions in blood glucose levels and this is related to their predominant effect on serotonin over noradrenaline reuptake
26. Lustman PJ, Griffith LS, Clouse RE, Freedland KE, Eisen SA, Rubin EG. Effects of Nortriptyline on depression and glycemic control in diabetes: results of a double-blind, placebo-controlled trial. Psychosom Med 1997; 59:241-250. This is an elegant, sophisticated and informative model study. The authors analyse the results in depth to provide important new information on underlying mechanisms. Depression in diabetic patients was successfully treated with nortriptyline but at the expense of a direct hyperglycaemic effect. However, lessening of depression scores on the Beck Depression Inventory was associated with a treatment-independent improvement of glycaemic control
27. Roose SP, Laghrissi-Thode F, Kennedy JS, Nelson JC, Bigger JT, Pollock BG, et al. Comparison of paroxetine and nortriptyline in depressed patients with ischemic heart disease. JAMA 1998; 279:287-291. This is one of the first studies examing the role of the SSRIs in treating depression in the medically ill. The absence of a placebo control reduces the effective conclusions that can be drawn. However, the authors' review and consideration of physiological factors associated with TCA and SSRI treatment in this patient group are detailed and sophisticated
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