Epstein-Barr virus-transformed lymphoblastoid cell lines of ataxia telangiectasia patients are defective in X-ray-induced apoptosis

International Journal of Radiation Biology

Volumn 75, Issue 6, 1999, Pages 709-716

  Meijer, A E ^a,b   Zhivotovsky, B ^c   Lewensohn, R ^a,c  

^a Swedish Radiation Protection Authority   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; ARTICLE; ATAXIA TELANGIECTASIA; CONTROLLED STUDY; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL; PRIORITY JOURNAL; RADIOSENSITIVITY; VIRUS CELL TRANSFORMATION; X RAY;

APOPTOSIS; ATAXIA TELANGIECTASIA; CELL CYCLE; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, VIRAL; DNA FRAGMENTATION; G1 PHASE; HERPESVIRUS 4, HUMAN; HUMANS; LYMPHOCYTES; MOLECULAR WEIGHT; RADIATION TOLERANCE; X-RAYS;

ATAXIA; ATAXIA TELANGIECTASIA; HUMAN HERPESVIRUS 4;

EID: 0033061336     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530099140041     Document Type: Article

References (30)

1. Beamish, H., Khanna, K. K. and Lavin, M. F., 1994, Ionizing radiation and cell cycle progression in ataxia telangiectasia. Radiation Research, 138, S130-S133.
2. Beamish, H. and Lavin, M. F., 1994, Radiosensitivity in ataxiatelangiectasia: anomalies in radiation-induced cell cycle delay. International Journal of Radiation Biology, 65, 175-184.
3. Canman, C. E., Wolff, A. C., Chen, C.-Y., Fornace JR, A. J. and Kastan, M. B., 1994, The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia. Cancer Research, 54, 5054-5058.
4. Castro, J., Heiden, T., Wang, N. and Tribukait, B., 1993, Preparation of cell nuclei from fresh tissues for high-quality DNA flow cytometry. Cytometry, 14, 793-804.
5. Duchaud, E., Ridet, A., Delic, Y., Cundari, E., Moustacchi, E. and Rosselli, F., 1994, Changes in ihe radiationinduced apoptotic response in homozygotes and heterozygotes for the ataxia-telangiectasia gene. C R Acad Sci III, 317, 983-989.
6. Duchaud, E., Ridet, A., Stoppa-Lyonnet, D., Janin, N., Moustacchi, E. and Rosselli, F., 1996, Deregulated apoptosis in ataxia telangiectasia: association with clinical stigmata and radiosensitivity. Cancer Research, 56, 1400-1404.
7. Foray, N., Priestley, A., Alsbeth, G., Badie, C., Capulas, E. P., Arlett, C. F. and Malaise, E. P., 1997, Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with repair deficiency of DNA double-strand breaks. International Journal of Radiation Biology, 72, 271-283.
8. Fotedar, R., Diedrich, L. and Foterdar, A., 1996, Apoptosis and the cell cycle. Progress in Cell Cycle Research, 2, 147-163.
9. Humar, B., Müller, H. and Scott, R. J., 1997, Elevated frequency of p53-independent apoptosis after irradiation increases levels of DNA breaks in ataxia telangiectasia lymphoblasts. International Journal of Radiation Biology, 72, 257-269.
10. Jörgensen, T. J. and Shiloh, Y., 1996, The ATM gene and the radiobiology of ataxia-telangiectasia. International Journal of Radiation Biology, 69, 527-537.
11. Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B. and Fornace, A. J., 1992, A mammalian cell cycle checkpoint pathway utilizing p53 and GADD15 is defective in ataxia-telangiectasia. Cell, 71, 587-597.
12. Khanna, K. K., Beamish, H., Yan, J., Habso, K., Williams, R., Dunn, I. and Laven, M. F., 1995, Nature, of G1/S cell cycle checkpoint defect in ataxia-telangiectasia. Oncogene, 11, 609-618.
13. Khanna, K. K. and Lavin, M. F., 1993, Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells. Oncogene, 8, 3307-3312.
14. Lücke-Huhle, C., 1994, Alterations in oncogene expression and radiosensitivity in the most frequently used SV40-transformed human skin fibroblasts. International Journal of Radiation Biology, 65, 665-673.
15. Maity A., McKenna, W. G. and Muchel, R. J., 1994, The molecular basis for cell cycle delays following ionizing radiation: a review. Radiatherapy and Oncology, 31, 1-13.
16. McKinnon, P. J., 1987, Ataxia-telangiectasia: an inherited disorder of ionizing-radiation sensitivity in man. Progress in the clucidation of the underlying biochemical defect. Human Genetics, 75, 197-208.
17. Meijer, A, E., Kronqvist, U.-S. E., Lewensohn, R. and Harms-Ringdahl, M., 1998, RBE for the induction of apoptosis in human peripheral lymphocytes exposed in vitru to high-LET radiation generated by accelerated nitrogen ions, International Journal of Radiation Biology, 73, 169-177.
18. Meyn, M. S., 1995, Ataxia-telangiectasia and cellular responses to DNA damage. Cancer Research, 55, 5991-6001,
19. Meyn, M. S., Strasfeld, L. and Allen, C., 1994, Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiectasia. International Journal of Radiation Biology, 66, S141-S149.
20. Painter, R. B. and Young, B. R., 1980, Radiosensitivity in ataxia-telangiectasia: a new explanation. Proceeding of the National Academy of Sciences, U S A, 77, 7315-7317.
21. Russel, J., Wheldon, T. E. and Stanton, P., 1995, A radioresistant variant derived from a human neuroblastoma cell line is less prone to radiation-induced apoptosis. Cancer Research, 55, 4915-4921.
22. Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagatte, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., Ashkenazi, M., Pecker, I., Frydman, M., Harnik, R., Patanjali, S. R., Simmons, A., Clines, G. A., Sartiel, A., Gatti, R. A., Chessa, L., Sanal, O., Lavin, M. F., Jaspers, N. G. J., Taylor, A. M. R., Arlett, C. F., Miki, T., Weissman, S. M., Lovett, M., Collins, F. S. and Shilou, Y., 1995, A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science, 268, 1749-1753.
23. Siles, E., Villalobos, M., Valenzuela, M. T., Nunez., M. I., Gordon, A., McMillan, T. J., Pedraza, V. and Ruiz De Almodovar, J. M., 1996, Relationship between p53 status and radiosensitivity in human tumour cell lines. British Journal of Cancer, 73, 581-588.
24. Skog, S., Lewensohn, R., He, Q., Borg, A.-L. and Gatti, R., 1997, Kinetics of G1/S and G2/M transition in X-irradiated ataxia-telangiectasia cells. Cancer Detection and Prevention, 21, 91-102.
25. Vidair, C. A., Chen, C. H., Ling, C. C. and Dewey, W. C., 1996, Apoptosis induced by X-irradiation of rec-myc cells is postmitotic and not predicted by the time after irradiation or behaviour of sister cells. Cancer Research, 56, 4116-4118.
26. Walker, P. R., Kokileva, L., LeBlanc, J. and Sikorska, M., 1993, Detection of the initial stages of DNA fragmentation in apoptosis. Bio Techniques, 15, 1032-1040.
27. Wyllie, H., Kerr, J. F. and Currie, A. R., 1980, Cell death: the significance of apoptosis. International Review of Cytology, 68, 251-306.
28. Xie, G., Habbersett, R. C., Jia, Y., Peterson, S. R., Lehnert, B. E., Bradbury, E. M. and D'Anna, J. A., 1998, Requirements for p53 and the ATM gene product in the regulation of G1/S and S phase checkpoints. Oncogene, 16, 721-736.
29. Zhivotovsky, B., Wade, D., Gahm, A., Orrenius, S. and Nicotera, P., 1994b, Formation of 50kbp chromatin fragments in isolated liver nuclei is mediated by protease and endonuclease activation. FEBS Letters. 351, 150-154.
30. Zhivotovsky B., Wade, D., Nicotera, P. and Orrenius, S., 1994a, Role of nucleases in apoptosis. International Archive of Allergy and Immunology, 105, 333-338.