Clarithromycin attenuates the inflammatory response induced by surgical trauma in a guinea pig model

Pharmacological Research

Volumn 39, Issue 1, 1999, Pages 49-54

  Woo, P C Y ^a   Chow, L W C ^b   Ma, E S K ^a   Yuen, K Y ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b Department of Surgery ^*  (China)

Author keywords

Clarithromycin; Inflammatory response; Surgical trauma

Indexed keywords

CLARITHROMYCIN; HEMOGLOBIN; MACROLIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASOPHIL; BODY TEMPERATURE; CONTROLLED STUDY; EOSINOPHIL; GUINEA PIG; INFLAMMATION; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MALE; MONOCYTE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; SURGICAL INJURY; THROMBOCYTE COUNT;

EID: 0033059971     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1998.0400     Document Type: Article

References (17)

1. Ritts RE. Antibiotics as biological response modifiers. J Antimicrob Chemother 1990; 26C: 31-6.
2. Keicho N, Kudoh S, Yotsumoto H, Akagawa S. Erythromycin promotes monocyte to macrophage differentiation. J Antibiotics 1994; 47: 80-9.
3. Cuffini AM, Carlone NA, Tullio V, Borsotto M. Comparative effects of roxithromycin and erythromycin on cellular immune functions in vitro. 3. Killing of intracellular staphylococcus aureus by human macrophages. Microbios 1989; 58: 27-33.
4. van der Auwera P, Bonnet M, Husson M, Jacobs F. Antibiotics and phagocytic cell function: A critical review. In: Faist E, Meakins JL, Schildberg E, eds. Defence Dysfunction in Trauma, Shock and Sepsis. Heidelberg: Springer-Verlag, 1990: 167-73.
5. Gemmell CG. Antibiotics and neutrophil function - Potential immunomodulating activities. J Antimicrob Chemother 1992; 30B: 23-33.
6. Nagai H, Shishido H, Yoneda R, Yamaguchi E, Tamura A, Kurashima A. Long-term low-dose administration of erythromycin to patients with diffuse panbronchiolitis. Respiration 1991; 58: 145-9.
7. Scaglione F, Rossoni G. Comparative anti-inflammatory effects of roxithromycin, azithromycin and clarithromycin. J Antimicrob Chemother 1998; 41B: 47-50.
8. Itkin IH, Menzel ML. The use of macrolide antibiotic substances in the treatment of asthma. J Allergy 1970; 45: 146-62.
9. Spector SL, Katz FH, Farr RS. Troleandomycin: Effectiveness in steroid-dependent asthma and bronchitis. J Allergy Clin Immunol 1974; 54: 367-79.
10. PlewinG G, Schopf E. Anti-inflammatory effects of antimicrobial agents: An in vivo study. J Invest DerMatol 1975; 65: 532-6.
11. 3h- Staphylococcus aureus by human macrophages. Microbios 1989; 58: 17-25.
12. Kita E, Sawaki M, Mikasa K, Hamada K, Takeuchi S, Maeda K, Narita N. Alterations of host response by a long-term treatment of roxithromycin. J Antimicrob Chemother 1993; 32: 285-94.
13. Fujii T, Kadota J, Kawakami K, Iida K, Shirai R, Kaseda M, Kawamoto S, Kohno S. Long term effect of erythromycin therapy in patients with chronic pseudomonas aeruginosa infection. Thorax 1995; 50: 1246-52.
14. Miyatake H, Taki F, Taniguchi H, Suzuki R, Takagi K, Satake T. Erythromycin reduces the severity of bronchial hyperresponsiveness in asthma. Chest 1991; 99: 670-3.
15. Shapira L, Soskolne WA, Houri Y, Barak V, Halabi A, Stabholz A. Protection against endotoxic shock and lipopolysaccharide-induced local inflammation by tetracycline: Correlation with inhibition of cytokine secretion. Infect Immun 1996; 64: 825-8.
16. Milano S, Arcoleo F, D'Agostino P, Cillari E. Intraperitoneal injection of tetracyclines protects mice from lethal endotoxemia downregulating inducible nitric oxide synthase in various organs and cytokine and nitrate secretion in blood. Antimicrob Agents Chemother 1997; 41: 117-21.
17. Nichols RL, Smith JW, Garcia RY, Waterman RS, Holmes WC. Current practices of preoperative bowel preparation among north american colorectal surgeons. Clin Infect Dis 1997; 24: 609-19.