The role of hepatocyte growth factor and its receptor c-Met in multiple myeloma and other blood malignancies

Leukemia and Lymphoma

Volumn 32, Issue 3-4, 1999, Pages 249-256

  BØrset, Magne ^a   Seidel, Carina ^a   Hjorth Hansen, Henrik ^a   Waage, Anders ^a   Sundan, Anders ^a  

^a TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

Author keywords

Blood malignancies; Hepatocyte growth factor; Multiple myeloma; Receptor c Met

Indexed keywords

CYTOKINE; SCATTER FACTOR; SCATTER FACTOR RECEPTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ANGIOGENESIS; BLOOD DISEASE; BONE TURNOVER; CANCER CELL CULTURE; CELL COMMUNICATION; CELL PROTECTION; CELL TRANSFORMATION; HEMATOPOIESIS; LIVER CELL; LIVER PARENCHYMA; LIVER REGENERATION; MESENCHYME CELL; MULTIPLE MYELOMA; ONCOGENE; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REVIEW; TARGET CELL;

EID: 0033058960     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199909167385     Document Type: Review

References (60)

1. Kan, M., Zhang, G.H., Zarnegar, R., Michalopoulos, G., Myoken, Y., McKeehan, W.L. and Stevens, J.I. (1991) Hepatocyte growth factor/hepatopoietin A stimulates the growth of rat kidney proximal tubule epithelial cells (RPTE), rat nonparenchymal liver cells, human melanoma cells, mouse keratinocytes and stimulates anchorage-independent growth of SV-40 transformed RPTE. Biochem. Biophys. Res. Commun. 174, 331-337.
2. Rubin, J.S., Chan, A.M., Bottaro, D.P., Burgess, W.H., Taylor, W.G., Cech, A.C., Hirschfield, D.W., Wong, J., Miki, T., Finch, P.W. and Aaronson, S.A. (1991) A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor. Proc. Natl. Acad. Sci. U. S. A. 88, 415-419.
3. Bussolino, F., Di Renzo, M.F., Ziche, M., Bocchietto, E., Olivero, M., Naldini, L., Gaudino, G., Tamagnone, L., Coffer, A. and Comoglio, P.M. (1992) Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J. Cell Biol. 119, 629-641.
4. Otonkoski, T., Beattie, G.M., Rubin, J.S., Lopez, A.D., Baird, A. and Hayek, A. (1994) Hepatocyte growth factor/scatter factor has insulinotropic activity in human fetal pancreatic cells. Diabetes, 43, 947-953.
5. Kawaida, K., Matsumoto, K., Shimazu, H. and Nakamura, T. (1994) Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration in mice. Proc. Natl. Acad. Sci. U. S. A.91, 4357-4361.
6. Tsao, M.S., Zhu, H., Giaid, A., Viallet, J., Nakamura, J. and Park, M. (1993) Hepatocyte growth factor/scatter factor is an autocrine factor for human normal bronchial epithelial and lung carcinoma cells. Cell Growth Differ. 4, 571-579.
7. Watanabe, S., Hirose, M., Wang, X.E., Maehiro, K., Murai, T., Kobayashi, O., Nagahara, A. and Sato, N. (1994) Hepatocyte growth factor accelerates the wound repair of cultured gastric mucosal cells. Biochem. Biophys. Res. Commun. 199, 1453-1460.
8. Kataoka, H., Gohda, E., Matsunaga, T., Ishii, T., Hara, H. and Yamamoto, I. (1993) Stimulation of DNA synthesis in skin fibroblasts by human hepatocyte growth factor/scatter factor. Cell. Biol. Int. 17, 65-73.
9. Yanagita, K., Matsumoto, K., Sekiguchi, K., Ishibashi, H., Niho, Y. and Nakamura, T. (1993) Hepatocyte growth factor may act as a pulmotrophic factor on lung regeneration after acute lung injury. J. Biol. Chem. 268, 21212-21217.
10. Watabe, M., Matsumoto, K., Nakamura, T. and Takeichi, M. (1993) Effect of hepatocyte growth factor on cadherin-mediated cell-cell adhesion. Cell Structure And Function, 18, 117-124.
11. Uehara, V., Minowa, O., Mori, C., Shiota, K., Kuno, J., Noda, T. and Kitamura, N. (1995) Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature, 373, 702-705.
12. Schmidt, C., Bladt, F., Goedecke, S., Brinkmann, V., Zschiesche, W., Sharpe, M., Gherardi, E. and Birchmeier, C. (1995) Scatter factor/hepatocyte growth factor is essential for liver development. Nature, 373, 699-702.
13. Bladt, F., Riethmacher, D., Isenmann, S., Aguzzi, A. and Birchmeier, C. (1995) Essential role for the c-Met receptor in the migration of myogenic precursor cells into the limb bud [see comments]. Nature, 376, 768-771.
14. Stoker, M., Gherardi, E., Perryman, M. and Gray, J. (1987) Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature, 327, 239-242.
15. Weidner, K.M., Behrens, J., Vandekerckhove, J. and Birchmeier, W. (1990) Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells. J. Cell Biol. 111, 2097-2108.
16. Grant, D.S., Kleinman, H.K., Goldberg, I.D., Bhargava, M.M., Nickoloff, B.J., Kinsella, J.L., Polverini, P. and Rosen, E.M. (1993) Scatter factor induces blood vessel formation in vivo. Proc. Natl.Acad. Sci. U. S. A. 90, 1937-1941.
17. Park, M., Dean, M., Cooper, C.S., Schmidt, M., O'Brien, S.J., Blair, D.G. and Vande Woude, G.F. (1986) Mechanism of met oncogene activation. Cell, 45, 895-904.
18. Cooper, C.S., Park, M., Blair, D.G., Tainsky, M.A., Huebner, K., Croce, C.M. and Vande Woude, G.F. (1984) Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature, 311, 29-33.
19. Takayama, H., LaRochelle, W.J., Sharp, R., Otsuka, T., Kriebel, P., Anver, M., Aaronson, S.A. and Merlino, G. (1997) Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor scatter factor. Proc. Natl. Acad. Sci. USA, 94, 701-706.
20. Tsarfaty, I., Rong, S., Resau, J.H., Rulong, S., da Silva, P.P. and Vande Woude, G.F. (1994) The Met proto-oncogene mesenchymal to epithelial cell conversion. Science, 263, 98-101.
21. Rong, S., Bodescot, M., Blair, D., Dunn, J., Nakamura, T., Mizuno, K., Park, M., Chan, A., Aaronson, S. and Vande Woude, G.F. (1992) Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor. Mol. Cell Biol. 12, 5152-5158.
22. Bellusci, S., Moens, G., Gaudino, G., Comoglio, P., Nakamura, T., Thiery, J.P. and Jouanneau, J. (1994) Creation of an hepatocyte growth factor/scatter factor autocrine loop in carcinoma cells induces invasive properties associated with increased tumorigenicity. Oncogene, 9, 1091-1099.
23. Ferracini, R., Di Renzo, M.F., Scotlandi, K., Baldini, N., Olivero, M., Lollini, P., Cremona, O., Campanacci, M. and Comoglio, P.M. (1995) The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit. Oncogene, 10, 739-749.
24. Ebert, M., Yokoyama, M., Friess, H., Buchler, M.W. and Korc, M. (1994) Coexpression of the c-Met proto-oncogene and hepatocyte growth factor in human pancreatic cancer. Cancer Res. 54, 5775-5778.
25. Rong, S., Jeffers, M., Resau, J.H., Tsarfaty, I., Oskarsson, M. and Vande Woude, G.F. (1993) Met expression and sarcoma tumorigenicity. Cancer Res. 53, 5355-5360.
26. Nishino, T., Hisha, H., Nishino, N., Adachi, M. and Ikehara, S. (1995) Hepatocyte growth factor as a hematopoietic regulator. Blood, 85, 3093-3100.
27. Hara, J., Matsumoto, K., Hosoi, G., Osugi, Y., Tawa, A., Okada, S. and Nakamura, T. (1997) Hepatocyte growth factor is constitutively produced by human hone marrow stromal cells and indirectly promotes hematopoiesis. Blood, 89, 1560-1565.
28. Galimi, F., Bagnara, G.P., Bonsi, L., Cottone, E., Follenzi, A., Simeone, A. and Comoglio, P.M. (1994) Hepatocyte growth factor induces proliferation and differentiation of multipotent and erythroid hemopoietic progenitors. J. Cell Biol. 127, 1743-1754.
29. Ratajczak, M.Z., Marliez, W., Ratajczak, J., Wasik, M., Machalinski, B., Carter, A. and Gewirtz, A.M. (1997) Effect of hepatocyte growth factor on early human haemopoietic cell development. British Journal Of Haematology, 99, 228-236.
30. Weimar, I.S., de Jong, D., Muller, E.J., Nakamura, T., van Gorp, J.M.H.H., de Gast, G.C. and Gerritsen, W.R. (1997) Hepatocyte Growth Factor/Scatter Factor Promotes Adhesion of Lymphoma Cells to Extracellular Matrix Via alpha4beta1 and alpha5beta1 Integrins. Blood, 89, 990-1000.
31. Goff, J.P., Shields, D.S., Petersen, B.E., Zajac, V.F., Michalopoulos, G.K. and Greenberger, J.S. (1996) Synergistic effects of hepatocyte growth factor on human cord blood CD34+ progenitor cells are the result of c-Met receptor expression. Stem Cells, 14, 592-602.
32. Ikehara, S. (1996) Role of hepatocyte growth factor in hemopoiesis. Leukemia & Lymphoma, 23, 297-303.
33. Jucker, M., Gunther, A., Gradl, G., Fonatsch, C., Krueger, G., Diehl, V. and Tesch, H. (1994) The Met/hepatocyte growth factor receptor (HGFR) gene is overexpressed in some cases of human leukemia and lymphoma. Leuk. Res. 18, 7-16.
34. Di Renzo, M.F., Narsimhan, R.P., Olivero, M., Bretti, S., Giordano, S., Medico, E., Gaglia, P., Zara, P. and Comoglio, P.M. (1991) Expression of the Met/HGF receptor in normal and neoplastic human tissues. Oncogene, 6, 1997-2003.
35. Delaney, B., Koh, W.S., Yang, K.H., Strom, S.C. and Kaminski, N.E. (1993) Hepatocyte growth factor enhances B-cell activity. Life Sci. 53, PL89-93.
36. Borset, M., Hjort-Hansen, H., Seidel, C., Sundan, A. and Waage, A. (1996) Hepatocyte Growth Factor and Its Receptor c-Met in Multiple Myeloma. Blood, 88, 3998-4004.
37. Chen, Q.Y., Defrances, M.C. and Zarnegar, R. (1996) Induction of met proto-oncogene (Hepatocyte growth factor receptor) expression during human monocyte-macrophage differentiation. Cell Growth & Diff., 7, 821-832.
38. Beilmann, M., Odenthal, M., Jung, W., VandeWoude, G.F., Dienes, H.P. and Schirmacher, P. (1997) Neoexpression of the c-Met hepatocyte growth factor scatter factor receptor gene in activated monocytes. Blood, 90, 4450-4458.
39. Nakamura, S., Gohda, E., Matsuo, Y., Yamamoto, I. and Minowada, J. (1994) Significant amount of hepatocyte growth factor detected in blood and bone marrow plasma of leukaemia patients. Br. J.Haematol. 87, 640-642.
40. Sato, T., Hakeda, Y., Yamaguchi, Y., Mano, H., Tezuka, K., Matsumoto, K., Nakamura, T., Mori, Y., Yoshizawa, K., Sumitani, K., Kodama, H. and Kumegawa, M. (1995) Hepatocyte growth factor is involved in formation of osteoclast-like cells mediated by clonal stromal cells (MC3T3-G2/PA6). J.Cell Physiol. 164, 197-204.
41. Fuller, K., Owens, J. and Chambers, T.J. (1995) The effect of hepatocyte growth factor on the behaviour of osteoclasts. Biochem. Biophys. Res. Commun. 212, 334-340.
42. Grano, M., Galimi, F., Zambonin, G., Collucci, S., Cottone, E., Zambonin Zallone, and A. Comoglio, P.M. (1996) Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro. Proc.Natl.Acad.Sci. USA, 93, 7644-7648
43. Thomson, B.M., Saklatvala, J. and Chambers, T.J. (1986) Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclasts. Journal Of Experimental Medicine, 164, 104-112.
44. Thomson, B.M., Mundy, G.R. and Chambers, T.J. (1987) Tumor necrosis factors alpha and beta induce osteoblastic cells to stimulate osteoclastic bone resorption. Journal Of Immunology, 138, 775-779.
45. Borset, M., Lien, E., Espevik, T., Helseth, E., Waage, A. and Sundan, A. (1996) Concomitant expression of hepatocyte growth factor/scatter factor and its receptor c-Met in human myeloma cell lines. J. Biol. Chem. 271, 24655-24661.
46. Seidel, C., Borset, M., Turesson, I., Abildgaard, N., Sundan, A. and Waage, A. (1998) Elevated Serum Concentrations of Hepatocyte Growth Factor in Patients with Multiple Myeloma. Blood, 91, 806-812.
47. Borset, M., Waage, A. and Sundan, A. (1996) Hepatocyte Growth Factor Reverses the TGFbeta-induced Growth Inhibition of CCL-64 cells: A Novel Bioassay for HGF and Implications for the TGFbeta Bioassay. Journal of Immunological Methods, 189, 59-64.
48. Eagles, G., Warn, A., Ball, R.Y., Baillie Johnson, H., Arakaki, N., Daikuhara, Y. and Warn, R.M. (1996) Hepatocyte growth factor/scatter factor is present in most pleural effusion fluids from cancer patients. Br. J Cancer, 73, 377-381.
49. Bataille, R., Chappard, D., Marcelli, C., Rossi, J.F., Dessauw, P., Baldet, P., Sany, J. and Alexandre, C. (1990) Osteoblast stimulation in multiple myeloma lacking lytic bone lesions. Br. J Haematol. 76, 484-487.
50. Kawano, M., Yamamoto, I., Iwato, K., Tanaka, H., Asaoku, H., Tanabe, O., Ishikawa, H., Nobuyoshi, M., Ohmoto, Y., Hirai, Y. and et al (1989) Interleukin-1 beta rather than lymphotoxin as the major bone resorbing activity in human multiple myeloma. Blood, 73, 1646-1649.
51. Bataille, R. (1995) The mechanisms of bone lesions in human plasmacytomas. Stem Cells, 13(suppl 2), 40-47.
52. Garrett, I.R., Durie, B.G., Nedwin, G.E., Gillespie, A., Bringman, T., Sabatini, M., Bertolini, D.R. and Mundy, G.R. (1987) Production of lymphotoxin, a bone-resorbing cytokine, by cultured human myeloma cells. N. Engl. J. Med. 317, 526-532.
53. Borset, M., Helseth, E., Naume, B. and Waage, A. (1993) Lack of IL-secretion from human myeloma cells highly purified by immunomagnetic separation. Br. J. Haematol. 85, 446-451.
54. Hata, H., Xiao, H., Petrucci, M.T., Woodliff, J., Chang, R. and Epstein, J. (1993) Interleukin-6 gene expression in multiple myeloma: a characteristic of immature tumor cells. Blood, 81, 3357-3364.
55. Klein, B., Zhang, X.G., Jourdan, M., Content, J., Houssiau, F., Aarden, L., Piechaczyk, M. and Bataille, R. (1989) Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6. Blood, 73, 517-526.
56. Alsina, M., Choi, S.J., Devlin, R.D., Cruz, J.C. and Roodman, G.D. (1997) Assessment of the role of IL-1 beta in the pathogenesis of myeloma bone disease. Blood, 90, 2346
57. Caligaris Cappio, F., Gregoretti, M.G., Ghia, P. and Bergui, L. (1992) In vitro growth of human multiple myeloma: implications for biology and therapy. Hematol. Oncol. Clin. North Am. 6, 257-271.
58. OReilly, M.S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W.S., Flynn, E., Birkhead, J.R., Olsen, B.R. and Folkman, J. (1997) Endostatin: An endogenous inhibitor of angiogenesis and tumor growth. Cell, 88, 277-285.
59. PerezAtayde, A.R., Sallan, S.E., Tedrow, U., Connors, S., Allred, E. and Folkman, J. (1997) Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia. Am. J.Pathol. 150, 815-821.
60. Vacca, A., Ribatti, D., Ronvalli, L., Ranieri, G., Serio, G., Silvestris, F. and Dammacco, F. (1994) Bone-Marrow Angiogenesis and Progression in Multiple Myeloma. British Journal Of Haematology, 87, 503-508.