Keratoacanthomas have an immunosuppressive cytokine environment of increased IL-10 and decreased GM-CSF compared to squamous cell carcinomas

British Journal of Cancer

Volumn 80, Issue 10, 1999, Pages 1501-1505

  Lowes, M A ^a   Bishop, G A ^b   Cooke, B E ^c   Barnetson, R St C ^a   Halliday, G M ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b CENTENARY INSTITUTE   (Australia)

^c PRINCE OF WALES HOSPITAL   (Australia)

Author keywords

Skin cancer; Tumour development; Tumour immunology; Tumour regression

Indexed keywords

COMPLEMENT COMPONENT C3B RECEPTOR; CYTOKINE; GAMMA INTERFERON; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 8; LYMPHOTOXIN; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; KERATOACANTHOMA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN; SQUAMOUS CELL CARCINOMA;

ANTIGENS, CD3; CARCINOMA, SQUAMOUS CELL; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-10; KERATOACANTHOMA; NEOPLASM REGRESSION, SPONTANEOUS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0033058642     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690552     Document Type: Article

References (24)

1. Bishop GA, Rokahr KL, Lowes M, McGuinness PH, Napoli J, DeCruz DJ, Wong W-Y and McCaughan GW (1997) Quantitative reverse transcriptase-PCR amplification of cytokine mRNA in liver biopsy specimens using a non-competitive method. Immunol Cell Biol 75: 142-147
2. Chomezynski P and Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analyst Biochem 162: 156-159
3. Dallman MJ, Shiho O, Page TH, Wood KJ and Morris PJ (1991) Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway. J Exp Med 173: 79-87
4. Dranoff G, Jaffee E, Lazenby A, Golumbek P, Levitsky H, Brose K, Jackson V, Hamada H, Pardoll D and Mulligan RC (1993) Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc Natl Acad Sci USA 90: 3539-3543
5. Ehlers S and Smith KA (1991) Differentiation of lymphokine gene expression: the in vitro acquisition of T cell memory. J Exp Med 173: 25-36
6. Enk AH, Angeloni VL, Udey MC and Katz SI (1993) Inhibition Langerhans cell antigen-presenting function by IL 10. J Immunol 151: 2390-2398
7. Ghadially R and Ghadially FN (1993). Keratoacanthoma. In: Dermatology in General Medicine, Fitzpatrick TB, Eisen AZ, Wolff K, Freeberg IM and Austen KF (eds), pp. 848-855. McGraw-Hill: New York
8. Hunt MJ, Halliday GM, Weedon D, Cooke BE and Barnetson RStC (1994) Regression in basal cell carcinoma: an immunohistochemical analysis. Br J Dermatol 130: 1-8
9. Kim J, Modlin RL, Moy RL, Dubinett SM, McHugh T, Nickoloff BJ and Uyemura K (1995) IL-10 production in cutaneous basal and squamous cell carcinomas. J Immunol 155: 2240-2247
10. Kundu N, Beaty TL, Jackson MJ and Fulton AM (1996) Antimetastatic and antitumor activities of interleukin 10 in a murine model of breast cancer. J Natl Cancer Inst 88: 536-541
11. Kurt RA, Park JA, Panelli MC, Schluter SF, Marchalonis JJ, Carolus B and Akportaye ET (1995) T lymphocytes infiltrating sites of tumor rejection and progression display identical Vβ usage but different cytotoxic activities. J Immunol 154: 3969-3974
12. Le Boit PE (1995) Is keratoacanthoma a variant of squamous cell carcinoma. New insights into an old controversy ... soon? Am J Dermatopathol 17: 319-320
13. Lowes MA, Bishop GA, Crotty K, Barnetson RStC and Halliday GM (1997) T helper 1 cytokine mRNA is increased in spontaneously regressing primary melanomas. J Invest Dermatol 108: 914-919
14. Mantovani A (1994) Tumor-associated macrophages in neoplastic progression: a paradigm for the in vivo function of chemokines. Lab Invest 71: 5-16
15. Marks R, Foley P, Goodman G, Hage BH and Selwood TS (1986) Spontaneous remission of solar keratoses: the case for conservative management. Br J Dermatol 115: 649-655
16. Mosmann TR (1944) Properties and functions of interleukin-10. Adv Immunol 56: 1-26
17. Patel A, Halliday GM, Cooke BE and Barnetson RStC (1994) Evidence that regression in keratoacanthoma is immunologically mediated: a comparison with squamous cell carcinoma. Br J Dermatol 131: 789-798
18. Prehn RT (1996) The paradoxical association of regression with a poor prognosis in melanoma contrasted with a good prognosis in keratoacanthoma. Cancer Res 56: 937-940
19. Schwartz RA (1994) Keratoacanthoma. J Am Acad Dermatol 30: 1-19
20. Schwartz RA and Stoll HL (1993) Squamous cell carcinoma. In: Dermatology in General Medicine, Fitzpatrick TB, Eisen AZ, Wolff K, Freeberg IM and Austen KF (eds), pp. 821-839. McGraw-Hill: New York
21. Si Z, Hersey P and Coates AS (1996) Clinical responses and lymphoid infiltrates in metastatic melanoma following treatment with intralesional GM CSF. Mel Res 6: 247-255
22. Tefany FJ, Barnetson RStC, Halliday GM, McCarthy SW and McCarthy WH (1991) Immunocytochemical analysis of the cellular infiltrate in primary regressing and non-regressing malignant melanoma. J Invest Dermatol 97: 197-202
23. Yamamura M, Modlin RL, Ohmen JD and Moy RL (1993) Local expression of anti inflammatory cytokines in cancer. J Clin Invest 91: 1005-1010
24. Yamamura M, Uyemura K, Deans RJ, Weinberg K, Rea TH, Bloom BR and Modlin RL (1991) Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science 254: 277-279