Platelet aggregation in young men with contrasting predisposition to high blood pressure

American Journal of Hypertension

Volumn 12, Issue 2 I, 1999, Pages 115-119

  Dockrell, M E C ^a   Walker, B R ^a   Noon, J P ^a   Watt, G C M ^a   Williams, B C ^a   Webb, D J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Catecholamines; Endothelins; Epinephrine; Hypertension; Platelet

Indexed keywords

ADRENALIN; ENDOTHELIN 1; ENDOTHELIN RECEPTOR;

ADOLESCENT; ADULT; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; ESSENTIAL HYPERTENSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; PARENT; PRIORITY JOURNAL; PROGENY; THROMBOCYTE AGGREGATION;

EID: 0033058256     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0895-7061(98)00215-5     Document Type: Article

References (17)

1. P. Erne P. Bolli E. Burgisser F.R. Buhler Correlation of platelet calcium with blood pressure effect of antihypertensive therapy N Engl J Med 310 1984 1084 1088
2. K.H. Le Quan Sang M.A. Devynck Increased platelet cytosolic free calcium concentration in essential hypertension J Hypertens 4 1986 567 574
3. R.M. Touyz E.L. Schiffrin Effects of angiotensin and endothelin-1 on platelet aggregation and cytosolic pH and free calcium concentrations in essential hypertension Hypertension 22 1993 853 862
4. A.S. Hollister J. Onrot S. Lonce Plasma catecholamine modulation of alpha 2 adrenoceptor agonist affinity and sensitivity in normotensive and hypertensive human platelets J Clin Invest 77 1986 1416 1421
5. C. Lechi E. Arosio P. Minuz Increased platelet aggregation and intracellular calcium in hypertensive patients effect of cyclooxygenase blockade J Hypertens 7 1989 S160 S161
6. Y. Matsumoto Y. Ozaki T. Kariya S. Kumi Potentiating effects of endothelin on platelet activation induced by epinephrine and ADP Biochem Pharmacol 40 1990 909 911
7. M.E.C. Dockrell W.G. Haynes B.C. Williams D.J. Webb Endothelin-1 and aggregation of human platelets in vitro J Cardiovasc Pharmacol 22 1993 S204 S206
8. R.M. Touyz E.L. Schiffrin Role of protein kinase C in the anti-aggregatory effects of endothelin-1 on human platelets Clin Sci 88 1995 277 283
9. G.C.M. Watt S.B. Harrap C.J.W. Foy Abnormalities of glucocorticoid metabolism and the renin-angiotensin system a four corners approach to the identification of genetic determinants of blood pressure J Hypertens 10 1992 473 482
10. J.P. Noon B.R. Walker D.J. Webb Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure J Clin Invest 99 1997 1873 1879
11. S.B. Harrap R. Fraser G.C. Inglis Abnormal epinephrine release in young adults with high personal and parental blood pressures Circulation 96 1997 556 561
12. B.R. Walker D.I.W. Phillips J.P. Noon Increased glucocorticoid activity in men with cardiovascular risk factors Hypertension 31 1998 891 895
13. M.C. Michel O.-E. Brodde P.A. Insel Peripheral adrenergic receptors in hypertension Hypertension 16 1990 107 120
14. W. Siess Molecular mechanisms of platelet activation Physiol Rev 69 1989 159 177
15. W.G. Haynes M.F. Hand H. Johnstone Direct and sympathetically mediated venoconstriction in essential hypertension enhanced responses to endothelin-1 J Clin Invest 94 1994 1359 1364
16. M.C. Verhaar F.E. Strachan D.E. Newby Endothelin-A receptor antagonist mediated vasodilatation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade Circulation 97 1998 752 756
17. M.E.C. Dockrell D.J. Webb B.C. Williams Activation of the endothelin B receptor causes a dose-dependent accumulation of cyclic GMP in human platelets Blood Coagul Fibrinolysis 7 1996 178 180