Regulation and expression of multidrug resistance (MDR) transcripts in the intestinal epithelium

British Journal of Cancer

Volumn 80, Issue 8, 1999, Pages 1123-1131

  Li, M ^a   Hurren, R ^a   Zastawny, R L ^b   Ling, V ^c   Buick, R N ^d  

^a UNIVERSITY OF TORONTO   (Canada)

^b Allelix Biopharmaceutical Inc   (Canada)

^c BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

^d NONE

Author keywords

Differentiation; Gene expression; Intestine; Mdr1a; Mdr1b

Indexed keywords

MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENHANCER REGION; HAMSTER; INTESTINE EPITHELIUM; MALE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CRICETINAE; DRUG RESISTANCE, MULTIPLE; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MDR; INTESTINES; MOLECULAR SEQUENCE DATA; P-GLYCOPROTEIN; PROMOTER REGIONS (GENETICS); RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR CELLS, CULTURED;

EID: 0033058197     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690475     Document Type: Article

References (57)

1. (1993) Current Protocols in Molecular Biology, Vol. 1. John Wiley & Sons: New York
2. Asp NG, Gudmand-Hoyer E, Andersen B, Berg NO and Dahlqvist A (1975) Distribution of disaccharidases, alkaline phosphatase, and some intracellular enzymes along the human small intestine. Scand J Gastroenterol 10: 647-651
3. Borst P and Schinkel AH (1997) Genetic dissection of the function of mammalian P-glycoproteins. Trends Genet 13:
4. Bradley G, Georges E and Ling V (1990) Sex-dependent and independent expression of the P-glycoprotein isoforms in Chinese hamster. J Cell Physiol 145: 398-408
5. Bremer S, Hoof T, Wilke M, Busche R, Scholte B, Riordan JR, Maass G and Tummler B (1992) Quantitative expression patterns of multidrug-resistance P-glycoprotein (MDR1) and differentially spliced cystic fibrosis transmembrane-conductance regulator mRNA transcripts in human epithelia. Eur J Biochem 206: 137-149
6. Brown PC, Thorgeirsson SS and Silverman JA (1993) Cloning and regulation of the rat mdr2 gene. Nucleic Acids Res 21: 3885-3891
7. Buschman E, Arceci RJ, Croop JM, Che M, Arias IM, Housman DE and Gros P (1992) mdr2 encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies. J Biol Chem 267: 18093-18099
8. Cano-Gauci DF, Lualdi JC, Ouellette AJ, Brady G, Iscove NN and Buick RN (1993) In vitro cDNA amplification from individual intestinal crypts: a novel approach to the study of differential gene expression along the crypt-villus axis. Exp Cell Res 208: 344-349
9. Chomezynski P and Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate phenol chloroform extraction. Anal Biochem 162: 156-159
10. Cirillo LA, Emerson JA, Vacher J and Tyner AL (1995) Developmental regulation of alpha-fetoprotein expression in intestinal epithelial cells of transgenic mice. Dev Biol 168: 395-405
11. Cohen D, Yu L, Rzepka R and Horwitz SB (1994) Identification of two nuclear protein binding sites and their role in the regulation of the murine multidrug resistance mdr1a promoter. DNA Cell Biol 13: 641-649
12. Cohn SM, Simon TC, Roth KA, Birkenmeier EH and Gordon JI (1992) Use of transgenic mice to map cis-acting elements in the intestinal fatty acid binding protein gene (Fabpi) that control its cell lineage-specific and regional patterns of expression along the duodenal-colonic and crypt-villus axes of the gut epithelium. J Cell Biol 119: 27-44
13. Combates NJ, Rzepka RW, Chen Y-NP and Cohen D (1994) NF-IL6, a member of the C/EBP family of transcription factors, binds and trans-activates the human MDR1 gene promoter. J Biol Chem 269: 29715-29719
14. Cowell IG (1994) Repression versus activation in the control of gene transcription. Trends Biochem Sci 19: 38-42
15. Croop JM, Raymond M, Haber D, Devault A, Arceci RJ, Gros P and Housman DE (1989) The three mouse multidrug resistance (mdr) genes are expressed in a tissue specific manner in normal mouse tissues. Mol Cell Biol 9: 1346-1350
16. Deren JJ (1987) Development of intestinal structure and function. In Handbook of Physiology. Vol. III - Intestinal absorption. American Physiological Society: Washington DC.
17. Deuchars KL, Duthic M and Ling V (1992) Identification of distinct P-glycoprotein gene sequences in rat. Biochim Biophys Acta 1130: 157-165
18. Dudov KP and Perry RP (1984) The gene family encoding the mouse ribosomal protein L32 contains a uniquely expressed intron-containing gene and an unmutated processed gene. Cell 37: 457-468
19. Endicott JA, Juranka PF, Sarangi F, Gerlach JH, Deuchars KL and Ling V (1987) Simultaneous expression of two P-glycoprotein genes in drug-sensitive Chinese hamster ovary cells. Mol Cell Biol 7: 4075-4081
20. Fojo AT, Ueda K, Slamon DJ, Poplack DG, Gottesman MM and Pastan I (1987) Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci USA 84: 265-269
21. Furuya KN, Gebhardt R, Schuetz EG and Schuetz JD (1994) Isolation of rat pgp3 cDNA: evidence for gender and zonal regulation of expression in the liver. Biochim Biophys Acta 1219: 636-644
22. Gatmaitan ZC and Arias IM (1993) Structure and function of P-glycoprotein in normal liver and small intestine. Adv Pharmacol 24: 77-97
23. Gottesman MM and Pastan I (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62: 385-427
24. Gottesman MM, Hryeyna CA, Schoenlein PV, Germann UA and Pastan I (1995) Genetic analysis of the multidrug transporter. Annu Rev Genet 29: 607-649
25. Gottesman MM, Pastan I and Ambudkar SV (1996) P glycoprotein and multidrug resistance. Curr Opin Genet Dev 6: 610-617
26. Herschbach BM and Johnson AD (1993) Transcriptional repression in eukaryotes. Annu Rev Cell Biol 9: 479-509
27. Hsu SI, Cohen D, Kirschner LS, Lothstein L, Hartstein M and Horwitz SB (1990) Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells [published erratum appears in Mol Cell Biol 1990 10: 6101]. Mol Cell Biol 10: 3596-3606
28. Hu Y, Kazenwadel J and James R (1993) Isolation and characterization of the murine homeobox gene Cdx-1. Regulation of expression in intestinal epithelial cells. J Biol Chem 268: 27214-27225
29. Koh J, Sferra TJ and Collins FS (1993) Characterization of the cystic fibrosis transmembrane conductance regulator promoter region. Chromatin context and tissue-specificity. J Biol Chem 268: 15912-15921
30. Lee CH, Bradley G, Zhang JT and Ling V (1993) Differential expression of P-glycoprotein genes in primary rat hepatocyte culture. J Cell Physiol 157: 392-402
31. McDonald RA, Matthews RP, Idzerda RL and McKnight GS (1995) Basal expression of the cystic fibrosis transmembrane conductance regulator gene is dependent on protein kinase A activity. Proc Natl Acad Sci USA 92: 7560-7564
32. Madden MJ, Morrow CS, Nakagawa M, Goldsmith ME, Fairchild CR and Cowan KH (1993) Identification of 5′ and 3′ sequences involved in the regulation of transcription of the human mdr1 gene in vivo. J Biol Chem 268: 8290-8297
33. Mukhopadhyay T, Batsakis JG and Kuo MT (1988) Expression of the mdr (P-glycoprotein) gene in Chinese hamster digestive tracts. J Natl Cancer Inst 80: 269-275
34. Murphy LD, Herzog CE, Rudick JB, Fojo AT and Bates SE (1990) Use of the polymerase chain reaction in the quantitation of mdr-1 gene expression. Biochemistry 29: 10351-10356
35. Potten CS and Loeffler M (1990) Stem cells: attributes, cycles, spirals, pittalls and uncertainties. Lessons for and from the crypt. Development 110: 1001-1020
36. Quaroni A (1985) Development of fetal rat intestine in organ and monolayer culture. J Cell Biol 100: 1611-1622
37. Quaroni A (1986) Fetal characteristics of small intestinal crypt cells. Proc Natl Acad Sci USA 83: 1723-1727
38. Quaroni A and Isselbacher KJ. (1981) Cytotoxic effects and metabolism of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in duodenal and ileal epithelial cell cultures. J Natl Cancer Inst 67: 1353-1362
39. Quaroni A, Wands J, Trelstad RL and Isselbacher KJ (1979) Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteria. J Cell Biol 80: 248-265
40. Rajchel A, Chan YL and Wool IG (1988) The primary structure of rat ribosomal protein L32. Nucleic Acids Res 16: 2347
41. Ruetz S and Gros P (1994) Phosphatidylcholine translocase: a physiological role for the mdr2 gene. Cell 77: 1071-1081
42. Schrenk D, Gant TW, Preisegger K-H, Silverman JA, Marino PA and Thorgeirsson SS (1992) Induction of multidrug resistance gene expression during cholestasis in rats and non human primates. Hepatology 17: 854-860
43. Silverman JA and Hill BA (1995) Characterization of the basal and carcinogen regulatory elements of the rat mdr1b promoter. Mol Carcinog 13: 50-59
44. Silverman JA, Raunio H, Gant TW and Thorgeirsson SS (1991) Cloning and characterization of a member of the rat multidrug resistance (mdr) gene family. Gene 106: 229-236
45. Smit JJ, Mol CA, van Deemter L, Wagenaar E, Schinkel AH and Borst P (1995) Characterization of the promoter region of the human MDR3 P-glycoprotein gene. Biochim Biophys Acta 1261: 44-56
46. Song R, Ikeguchi M, Zhou G and Kuo MT (1995) Identification and characterization of a hepatoma cell-specific enhancer in the mouse multidrug resistance mdr1b promoter. J Biol Chem 270: 25468-25474
47. Suh E, Chen L, Taylor J and Traber PG (1994) A homeodomain protein related to caudal regulates intestine-specific gene transcription. Mol Cell Biol 14: 7340-7351
48. Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I and Willingham MC (1987) Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci USA 84: 7735-7738
49. Thorgeirsson SS, Grant TW and Silverman JA (1994) Transcriptional regulation of multidrug resistance gene expression. Cancer Treat Res 73: 57-68
50. Traber PG (1990) Regulation of sucrase isomaltase gene expression along the crypt-villus axis of rat small intestine. Biochem Biophys Res Commun 173: 765-773
51. Traber PG (1994) Differentiation of intestinal epithelial cells: lesions from the study of intestine-specific gene expression. J Lab Clin Med 123: 467-477
52. Trezise AE and Buchwald M (1991) In vivo cell-specific expression of the cystic fibrosis transmembrane conductance regulator. Nature 353: 434-437
53. Trier JS and Moxey PC (1979) Morphogenesis of the small intestine during fetal development. Ciba Found Symp 3: 29
54. Tyner AL, Godbout R, Compton RS and Tilghman SM (1990) The ontogeny of alpha-fetoprotein gene expression in the mouse gastrointestinal tract. J Cell Biol 110: 915-927
55. Van der Blick AM, Baas F, Ten Houte de Lange T, Kooiman PM, Van der Velde-Koerts T and Borst P (1987) The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver. Embo J 6: 3325-3331
56. Yu LY, Cohen D, Piekarz RL and Horwitz SB (1993) Three distinct nuclear protein binding sites in the promoter of the murine multidrug resistance mdr1b gene. J Biol Chem 268: 7520-7526
57. Zastawny RL and Ling V (1993) Structural and functional analysis of 5′ flanking and intron 1 sequences of the hamster P glycoprotein pgp1 and pgp2 genes. Biochim Biophys Acta 1173: 303-313