The potential of human mast cell progenitors to differentiate into mature mast cells remains after prolonged culture with flt3 ligand, interleukin-3 or granulocyte-macrophage colony stimulating factor

British Journal of Haematology

Volumn 104, Issue 3, 1999, Pages 516-522

  Hjertson, Malin ^a   Sundström, Christer ^a   Nilsson, Kenneth ^a   Nilsson, Gunnar ^a,b  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Cord blood; Cytokines; Haemopoiesis; Human; Mast cells

Indexed keywords

FLT3 LIGAND; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 3;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; CULTURE MEDIUM; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MAST CELL; PRIORITY JOURNAL; UMBILICAL CORD BLOOD;

EID: 0033058071     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1999.01198.x     Document Type: Article

References (44)

1. Adachi, S., Tsujimura, T., Jippo, T., Morimoto, M., Isozaki, K., Kasugai, T., Nomura, S. & Kitamura, Y. (1995) Inhibition of attachment between cultured mast cells and fibroblasts by phorbol 12-myristate 13-acetate and stem cell factor. Experimental Hematology, 23, 58-65.
2. Agis, H., Fureder, W., Bankl, H.C., Kundi, M., Sperr, W. R., Willheim, M., Boltznitulescu, G., Butterfield, J.H., Kishi, K., Lechner, K. & Valent, P. (1996) Comparative immunophenotypic analysis of human mast cells, blood basophils and monocytes. Immunology, 87, 535-543.
3. -, colony-forming cell. Journal of Immunology, 151, 4221-4227.
4. Baghestanian, M., Agis, H., Bevec, D., Bankl, H.C., Hofbauer, R., Kress, H.G., Butterfield, J.H., Muller, M.R., Ashman, L.K., Fureder, W., Willheim, M., Lechner, K. & Valent, P. (1996) Stem cell factor-induced downregulation of c-kit in human lung mast cells and HMC-1 mast cells. Experimental Hematology, 24, 1377-1386.
5. Baldwin, G.C. (1992) The biology of granulocyte-macrophage colony-stimulating factor: effects on hematopoietic and non-hematopoietic cells. Developmental Biology, 151, 352-367.
6. Bressler, R.B., Thompson, H.L., Keffer, J.M. & Metcalfe, D.D. (1989) Inhibition of the growth of IL-3-dependent mast cells from murine bone marrow by recombinant granulocyte macrophage-colony-stimulating factor. Journal of Immunology, 143, 135-139.
7. Du, Z. M., Li, Y.L., Xia, H.Z., Irani, A.M. & Schwartz, L.B. (1997) Recombinant human granulocyte-macrophage colony-stimulating factor (CSF), but not recombinant human granulocyte CSF, down-regulates the recombinant human stem cell factor-dependent differentiation of human fetal liver-derived mast cells. Journal of Immunology, 159, 838-845.
8. Födinger, M., Fritsch, G., Emminger, W., Mitterbauer, G., Gadner, H., Valent, P. & Mannhalter, C. (1994) Origin of human mast cells: development from transplantated hematopoietic stem cells after allogeneic bone marrow transplantation. Blood, 84, 2954-2959.
9. Gabbianelli, M., Pelosi, E., Montesoro, E., Valtieri, M., Luchetti, L., Samoggia, P., Vitelli, L., Barberi, T., Testa, U., Lyman, S. & Peschle, C. (1995) Multi-level effects of flt 3 ligand on human hematopoiesis: expansion of putative stem cells and proliferation of granulomonocytic progenitors monocytic precursors. Blood, 86, 1661-1670.
10. Haylock, D.N., Horsfall, M.J., Dowse, T.L., Ramshaw, H.S., Niutta, S., Protopsaltis, S., Peng, L., Burrell, C., Rappold, I., Buhring, H.J. & Simmons, P.J. (1997) Increased recruitment of hematopoietic progenitor cells underlies the ex vivo expansion potential of FLT 3 ligand. Blood, 90, 2260-2272.
11. Hjertson, M., Sundström, C., Lyman, S.D., Nilsson, K. & Nilsson, G. (1996) Stem cell factor, but not fit 3 ligand, induces differentiation and activation of human mast cells. Experimental Hematology, 24, 748-754.
12. Ihle, J.N., Keller, J.R., Oroszlan, S., Henderson, L.E., Copeland, T.D., Fitch, F., Prystowsky, M.B., Goldwasser, E., Schrader, J.W., Palaszynski, E., Dy, M. & Lebel, B. (1983) Biologic properties of homogeneous interleukin-3. I. Demonstration of WEHI-3 growth factor activity, mast cell growth factor activity, p cell-stimulating factor activity, colony-stimulating factor activity, and histamine-producing cell-stimulating factor activity. Journal of Immunology, 131, 282-287.
13. Irani, A.A., Bradford, T.R., Kepley, C.L., Schechter, N.M. & Schwartz, L.B. (1989) Detection of MCT and MCTC types of human mast cells by immunohistochemistry using new monoclonal anti-tryptase and anti-chymase antibodies. Journal of Histochemistry and Cytochemistry, 37, 1509-1515.
14. Irani, A.A., Nilsson, G., Ashman, L.K. & Schwartz, L.B. (1995) Dexamethasone inhibits the development of mast cells from dispersed human fetal liver cells cultured in the presence of recombinant human stem cell factor. Immunology, 84, 72-78.
15. Irani, A.A., Nilsson, G., Miettinen, U., Craig, S.S., Ashman, L.K., Ishizaka, T., Zsebo, K.M. & Schwartz, L.B. (1992) Recombinant human stem cell factor stimulates differentiation of mast cells from dispersed human fetal liver cells. Blood, 80, 3009-3021.
16. Kirshenbaum, A.S., Goff, J.P., Dreskin, S.C., Irani, A.M., Schwartz, L.B. & Metcalfe, D.D. (1989) IL-3-dependent growth of basophil-like cells and mast-like cells from human bone marrow. Journal of Immunology, 142, 2424-2429.
17. + pluripotent progenitor cells. Journal of Immunology, 148, 772-777.
18. + bone marrow progenitor cells. Journal of Immunology, 146, 1410-1415.
19. Lyman, S.D., James, L., Johnson, L., Brasel, K., Devries, P., Escobar, S.S., Downey, H., Splett, R.R., Beckmann, M.P. & McKenna, H.J. (1994) Cloning of the human homologue of the murine flt 3 ligand: a growth factor for early hematopoietic progenitor cells. Blood, 83, 2795-2801.
20. Lyman, S.D. & Williams, D.E. (1995) Biology and potential clinical applications of flt 3 ligand. Current Opinion in Hematology, 2, 177-181.
21. Metcalf, D. (1993) Hematopoietic regulators: redundancy or subtlety. Blood, 82, 3115-3523.
22. Mitsui, H., Furitsu, T., Dvorak, A.M., Irani, A.A., Schwartz, L.B., Inagaki, N., Takei, M., Ishisaka, K., Zsebo, K.M., Gillis, S. & Ishizaka, T. (1993) Development of human mast cells from umbilical cord blood cells by recombinant human and murine C-kit ligand. Proceedings of the National Academy of Sciences of the United States of America, 90, 735-739.
23. Moore, M. (1991) Clinical implications of positive and negative hematopoietic stem cell regulators. Blood, 78, 1-19.
24. Neu, S., Geiselhart, A., Kuci, S., Baur, F., Niethammer, D. & Handgretinger, R. (1996) Isolation and phenotypic characterization of CD117-positive cells. Leukemia Research, 20, 963-71.
25. Nilsson, G., Blom, T., Harvima, I., Kusche-Gullberg, M., Nilsson, K. & Hellman, L. (1996) Stem cell factor-dependent human cord blood derived mast cells express α-and β-tryptase, heparin and chondroitin sulphate. Immunology, 88, 308-314.
26. Nilsson, G., Irani, A.A., Ishizaka, T. & Schwartz, L.B. (1992) Human recombinant stem cell factor (SCF), the ligand for c-kit, induces development of human mast cells whereas IL-3 induces basophil-like cells from fetal liver cells (FLC). FASEB Journal, 6, A1722.
27. Nilsson, G., Miettinen, U., Ishizaka, T., Irani, A.M. & Schwartz, L.B. (1994) IL-4 inhibits the expression of Kit and tryptase during the stem cell factor-dependent development of human mast cells from fetal liver cells. Blood, 84, 1519-1527.
28. Nilsson, G. & Nilsson, K. (1995) Effects of IL-13 on immediate-early response gene expression, phenotype and differentiation of human mast cells: comparison with IL.-4. European Journal of Immunology, 25, 870-873.
29. Ogawa, M. (1993) Differentiation and proliferation of hematopoietic stem cells. Blood, 81, 2844-2853.
30. Pharr, P.N. & Hofbauer, A. (1997) Loss of flk-2/flt 3 expression during commitment of multipotent mouse hematopoietic progenitor cells to the mast cell lineage. Experimental Hematology 25, 620-628.
31. Reisbach, G., Bartke, I., Kempkes, B., Kostka, G., Ellwart, J., Birner, A., Thalmeier, K., Mailhammer, R., Bornkamm, G.W., Ullrich, A. & Dörmer, P. (1993) Characterization of hemopoietic cell populations from human cord blood expressing c-kit. Experimental Hematology, 21, 74-79.
32. + Fc(epsilon)RI(-) cell population. Blood, 84, 2489-2496.
33. 2 from cord blood mononuclear cells. Journal of Immunology, 157, 343-350.
34. Saito, H., Hatake, K., Dvorak, A.M., Leiferman, K.M., Donnenberg, A.D., Arai, N., Ishizaka, K. & Ishizaka, T. (1988) Selective differentiation and proliferation of hematopoietic cell induced by recombinant human interleukins. Proceedings of the National Academy of Sciences of the United States of America, 85, 2288-2292.
35. Sakabe, H., Kimura, T., Zeng, Z., Minamiguchi, H., Tsuda, S., Yokota, S., Hodohara, K., Abe, T., Lyman, S.D. & Sonoda, Y. (1998) Haematopoietic action of flt 3 ligand on cord blood-derived CD 34-positive cells expressing different levels of flt 3 or c-kit tyrosine kinase receptor: comparison with stem cell factor. European Journal of Haematology, 60, 297-306.
36. Shimizu, Y., Ashman, L.K., Du, Z. & Schwartz, L.B. (1996) Internalization of Kit together with stem cell factor on human fetal liver-derived mast cells: new protein and RNA synthesis are required for reappearance of Kit. Journal of Immunology, 156, 3443-3449.
37. Sillaber, C., Sperr, W.R., Agis, H., Spanblöchl, E., Lechner, K. & Valent, P. (1994) Inhibition of stem cell factor dependent formation of human mast cells by interleukin-3 and interleukin-4. International Archives of Allergy and Immunology, 105, 264-268.
38. Sillaber, C., Strobl, H., Bevec, D., Ashman, L.K., Butterfield, J.H., Lechner, K., Maurer, D., Bettelheim, P. & Valent, P. (1991) IL-4 regulates c-kit proto-oncogene product expression in human mast and myeloid progenitor cells. Journal of Immunology, 147, 4224-4228.
39. (+) human bone marrow cells and is involved in the proliferation of early progenitor stem cells. Proceedings of the National Academy of Sciences of the United States of America, 91, 459-463.
40. Valent, P., Besemer, J., Muhm, M., Majdic, O., Lechner, K. & Bettelheim, P. (1989) Interleukin-3 activates human blood basophils via high affinity binding sites. Proceedings of the National Academy of Sciences of the United States of America, 86, 5542-5546.
41. Valent, P. & Bettelheim, P. (1992) Cell surface structures on human basophils and mast cells: biochemical and functional characterization. Advances in Immunology, 52, 333-423.
42. Valent, P., Spanblöchl, E., Sperr, W.R., Sillaber, C., Zsebo, K.M., Agis, H., Strobl, H., Geissler, K., Bettelheim, P. & Lechner, K. (1992) Induction of differentiation of human mast cells from bone marrow and peripheral blood mononuclear cells by recombinant human stem cell factor/kit-ligand in long-term culture. Blood, 80, 2237-2245.
43. Yee, N.S., Hsiau, C., Serve, H., Vosseller, K. & Besmer, P. (1994) Mechanism of down-regulation of c-kit receptor: roles of receptor tyrosine kinase, phosphatidylinositol 3′-kinase, and protein kinase C. Journal of Biological Chemistry, 269, 31991-31998.
44. Yee, N.S., Langen, H. & Besmer, P. (1993) Mechanism of Kit ligand, phorbol ester, and calcium-induced down-regulation of c-kit receptors in mast cells. Journal of Biological Chemistry, 268, 14189-14201.