Pharmacokinetics and therapeutic efficacy of rimantadine in horses experimentally infected with influenza virus A2

American Journal of Veterinary Research

Volumn 60, Issue 7, 1999, Pages 888-894

  Rees, William A ^a   Harkins, J Daniel ^b   Lu, Ming ^c   Holland Jr , Robert E ^b   Lehner, Andreas E ^b   Tobin, Thomas ^b   Chambers, Thomas M ^b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c University of Kentucky   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RIMANTADINE;

ADOLESCENT; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; FEMALE; HORSE; INFLUENZA; INFLUENZA VIRUS A; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PROPHYLAXIS; SCORING SYSTEM;

ADMINISTRATION, ORAL; ANIMALS; ANTIBODIES, VIRAL; ANTIVIRAL AGENTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHICK EMBRYO; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEMAGGLUTINATION INHIBITION TESTS; HORSE DISEASES; HORSES; INJECTIONS, INTRAVENOUS; MICROBIAL SENSITIVITY TESTS; NASAL MUCOSA; ORTHOMYXOVIRIDAE; ORTHOMYXOVIRIDAE INFECTIONS; RIMANTADINE;

ANIMALIA; EQUIDAE; EQUUS CABALLUS; INFLUENZA VIRUS; INFLUENZAVIRUS A;

EID: 0033057972     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Chambers TM, Shortridge KF, Li PH, et al. Rapid diagnosis of equine influenza by the Directigen FLU-A enzyme immunoassay. Vet Rec 1994;135:275-279.
2. Aoki FY, Sitar DS (1988). Clinical pharmacokinetics of amantadine hydrochloride. Clin Pharmacokinet 1988;14:35-51.
3. Bleidner WE, Harmon JB, Hewes WE, et al. Absorption, distribution and excretion of amantadine hydrochloride. J Pharmacol Experimental Ther 1965;150:484-490.
4. Vernier VG, Harmon JB, Stump JM, et al. The toxicology and pharmacologic properties of amantadine hydrochloride. Tox Applied Pharm 1969;15:642-665.
5. Bryans JT, Zent WW, Grunert RR, et al. 1-Adamantanamine hydrochloride prophylaxis for experimentally-induced A/equine 2 influenza virus infection. Nature 1966;212:1542-1544.
6. Dolin R, Reichman RC, Madore P, et al. A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection. New Engl J Med 1982;10:580-583.
7. Hayden FG, Hoffman HE, Spyker DA. Differences in side effects of amantadine hydrochloride and rimantadine hydrochloride relate to differences in pharmacokinetics. Antimicrob Agents Chemother 1983;23:458-464.
8. US Department of Health and Human Services, Centers for Disease Control. Prevention and control of influenza: part II, antiviral agents Morbid Mortal Week Rep 1994;34:1-10.
9. Hayden FG, Minocha A, Spyker DA, et al. Comparative single-dose pharmacokinetics of amantadine hydrochloride and rimantadine hydrochloride in young and elderly adults. Antimicrob Agents Chemother 1985;28:216-221.
10. Wills RJ, Farolino DA, Choma N, et al. Rimantadine pharmacokinetics after single and multiple doses. Antimicrob Agents Chemother 1987;31:826-828.
11. Brady MT, Sears SD, Pacini DL, et al. Safety and prophylactic efficacy of low-dose rimantadine in adults during an influenza A epidemic. Antimicrob Agents Chemother 1990;34:1633-1636.
12. Hayden FG, Gwaltney JM, Van de Castle RL, et al. Comparative toxicity of amantadine hydrochloride and rimantadine hydrochloride in healthy adults. Antimicrob Agents Chemother 1981;19:226-233.
13. Rees WA, Harkins JD, Woods WE, et al.. Amantadine and equine influenza: pharmacology, pharmacokinetics, and neurological effects in the horse. Equine Vet J 1997;29:104-110.
14. Herold DA, Anonick PK, Kinter M, et al. Measurement of rimantadine in plasma by capillary gas chromatograph/mass spectrometry with a deuterium-labeled internal standard. Clin Chem 1988;34:1597-1599.
15. Office International Des Epizooties. Manual of standards for diagnostic tests and vaccines. 3rd ed. Paris: Office International Des Epizooties, 1996.
16. Mumford JA and Chambers TM. Equine influenza. In: Nicholson KG, Webster RG, Hay AJ, eds. Textbook of influenza. London: Blackwell Science Ltd, 1998;146-162.
17. Noether GE. Introduction to statistics: the nonparametric way. New York: Springer-Verlag, 1991;279-281.
18. Hayden FG, Sperber SJ, Belshe RB, et al. Recovery of drug-resistant influenza A virus during therapeutic use of rimantadine. Antimicrob Agents Chemother 1991;35:1741-1747.
19. Mumford JA, Hannant D, Jessett DM. Experimental infection of ponies with equine influenza (H3N8) viruses by intranasal inoculation or exposure to aerosols. Equine Vet J 1990;22:93-98.