Activation of nigral dopamine neurons by the selective GABA(B)-receptor antagonist SCH 50911

Journal of Neural Transmission

Volumn 106, Issue 5-6, 1999, Pages 383-394

  Erhardt, S ^a   Nissbrandt, H ^b   Engberg, G ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Burst firing; Dopamine; Firing rate; SCH 50911; Substantia nigra

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; BACLOFEN; DOPAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CELL ACTIVATION; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; INTRAVENOUS DRUG ADMINISTRATION; MALE; MESENCEPHALON; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA;

EID: 0033057909     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007020050166     Document Type: Article

References (40)

1. Arnsten AF (1997) Catecholamine regulation of the prefrontal cortex. J Psychopharmacol 11: 152-162
2. Bean AJ, Roth RH (1991) Extracellular dopamine and neurotensin in rat prefrontal cortex in vivo: effects of median forebrain bundle stimulation frequency, stimulation pattern, and dopamine autoreceptors. J Neurosci 11: 2694-2702
3. B receptor antagonist CGP 35348 in the mouse. Brain Res 1: 135-136
4. Bolam JP, Smith Y (1990) The GABA and substance P input to dopaminergic neurones in the substantia nigra of the rat. Brain Res 529: 57-78
5. Bunney BS, Aghajanian GK (1976) The precise localization of nigral afferents in the rat as determined by a retrograde tracing technique. Brain Res 117: 423-435
6. Boiser DC, Blythin DJ, Chapman RW, Egan RW, Hey JA, Rizzo C, Kuo S-C, Kreutner W (1995) The pharmacology of SCH 50911: a novel, orally-active GABA-B receptor antagonist. J Pharmacol Exp Ther 274: 1393-1398
7. Dray A (1979) The striatum and substantia nigra: a commentary on their relationships. Neuroscience 4: 1407-1439
8. Engberg G (1989) Nicotine induced excitation of locus coeruleus neurons is mediated via release of excitatory amino acids. Life Sci 44: 1535-1540
9. B-receptors activation alters the firing pattern of dopamine neurons in the rat substantia nigra. Synapse 15: 229-238
10. Engberg G, Elverfors A, Jonason J, Nissbrandt H (1997) Inhibition of dopamine re-uptake: significance for nigral dopamine neuron activity. Synapse 25: 215-226
11. Erhardt S, Nissbrandt H, Andersson B, Engberg G (1998) Inhibition of firing rate and changes in the firing pattern of nigral dopamine neurons by γ -hydroxybutyric acid (GHBA) are specifically induced by activation of GABA-B receptors. Naunyn Schmiedebergs Arch Pharmacol 357: 611-619
12. Fischer RS (1989) GABAergic pallidonigral and "accessory" striatonigral connections demonstrated in cats by double peroxidase labelling. Synapse 4: 165-167
13. B antagonists. J Med Chem 38: 3313-3331
14. Gerten CR (1985) The neostriatal mosaic. I. Compartimental organization of projections from the striatum to the substantia nigra in the rat. J Comp Neurol 236: 454-476
15. Gonon FG (1988) Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied in vivo electrochemistry. Neuroscience 24: 19-28
16. Grace AA, Bunney BS (1979) Paradoxical GABA excitation of nigral dopaminergic cells: indirect mediation through reticulata inhibitory neurons. Eur J Pharmacol 59: 211-218
17. Grace AA, Bunney BS (1980) Effects of baclofen on nigral dopaminergic cell activity following acute and chronic haloperidol treatment. Brain Res Bull 5: 537-543
18. Grace AA, Bunney BS (1983) Intracellular and extracellular electrophysiology of nigral dopamine neurons. Identification and characterization. Neuroscience 10: 301-315
19. Grace AA, Bunney BS (1984a) The control of firing pattern in nigral dopamine neurons: single spike firing. J Neurosci 4: 2866-2876
20. Grace AA, Bunney BS (1984b) The control of firing pattern in nigral dopamine neurons: burst firing. J Neurosci 4: 2877-2890
21. Grace AA, Gerfen CR, Aston-Jones G (1998) Catecholamines in the central nervous system. Overview. In: Goldstein DS, Eisenhofer G, McCarty R (eds) Advances in pharmacology. Catecholamines bridging basic science with clinical medicine, 42nd edn. Academic Press, San Diego, pp 655-670
22. Graybiel AM (1997) The basal ganglia and cognitive pattern generators. Schizophr Bull 23: 459-469
23. Hajos M, Greenfield SA (1993) Topographic heterogeneity of substantia nigra neurons: diversity in intrinsic membrane properties and synaptic inputs. Neuroscience 55: 919-34
24. Johnsson SW (1998) Afferent control of midbrain dopamine neurons: an intracellular perspective. In: Goldstein DS, Eisenhofer G, McCarty R (eds) Advances in pharmacology. Catecholamines bridging basic science with clinical medicine, 42nd edn. Academic Press, San Diego, pp 691-694
25. B and dopamine D2 receptors in rat substantia nigra neurones. J Physiol 401: 437-453
26. MacNeil D, Gower M, Szymanska I (1978) Response of dopamine neurons in substantia nigra to muscimol. Brain Res 154: 401-403
27. Manley LD, Kuczenski R, Segal DS, Young SJ, Groves PM (1992) Effects of frequency and pattern of medial forebrain and bundle stimulation on caudate dialysate dopamine and serotonin. J Neurochem 58: 1491-1498
28. Nissbrandt H, Elverfors A, Engberg G (1994) Pharmacologically induced cessation of burst activity in nigral dopamine neurons: significance for the terminal dopamine efflux. Synapse 17: 217-224
29. Nitsch C, Riesenberg R (1988) Immunocytochemically demonstration of GABAergic synaptic connection in the rat substantia nigra after different lesion ks of the striatonigral projection. Brain Res 461: 127-142
30. B receptors. Eur J Pharmacol 187: 27-38
31. Overton PG, Clark D (1997) Burst firing in midbrain dopaminergic neurons. Brain Res Rev 25: 312-334
32. Precht W, Yoshida M (1971) Blockage of caudate-evoked inhibition of neurons in the substantia nigra by picrotoxin. Brain Res 346: 205-217
33. B receptors on neurones in rat brain slices. Br J Pharmacol 101: 949-957
34. Schultz W, Apicella P, Ljungberg T (1993) Responses of monkey dopamine neurons to reward and conditioned stimuli during successive steps of learning a delayed response task. J Neurosci 13: 900-913
35. Storm-Mathisen J, Ottersen OP (1989) Anatomy of putative glutamatergic neurons. In: Avoli M, Reader TA, Dykes RW, Gloor P (eds) Neurotransmitters and cortical function. Plenum, New York, pp 39-70
36. A receptor-mediated inhibition of rat substantia nigra dopaminergic neurons by pars reticulata projection neurons. J Neurosci 15: 3092-3103
37. Tepper JM, Paladini CA, Celada P (1998) GABAergic control of the firing pattern of substantia nigra dopaminergic neurons, In: Goldstein DS, Eisenhofer G, McCarty R (eds) Advances in pharmacology. Catecholamines bridging basic science with clinical medicine, 42nd edn. Academic Press, San Diego, pp 694-699
38. Walters JR, Lakoski JM (1978) Effect of muscimol on single unit activity of substantia nigra dopamine neurons. Eur J Pharmacol 47: 469-471
39. Waszczak BL, Eng N, Walters JR (1980) Effects of muscimol and picrotoxin on single unit activity of substantia nigra neurons. Brain Res 188: 185-197
40. Werner G, Mountcastle VB (1963) The variability of central neural activity in a sensory system and its implification for the central reflection of sensory events. J Neurophysiol 26: 958-977