Design of serine protease inhibitors with conformation restricted by amino acid side-chain-side-chain CH/π interaction

Biopolymers - Peptide Science Section

Volumn 51, Issue 1, 1999, Pages 9-17

  Shimohigashi, Yasuyuki ^a   Nose, Takeru ^a   Yamauchi, Yasuko ^a   Maeda, Iori ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

CH interaction; Chymotrypsin; Conformational restriction; Enzyme inhibitor; Inhibitory conformation

Indexed keywords

AMINO ACIDS; CATALYST ACTIVITY; CONFORMATIONS; CRYSTALLOGRAPHY; HYDROPHOBICITY; MOLECULAR DYNAMICS; MOLECULAR STRUCTURE;

CHYMOTRYPSIN; PEPTIDES; SERINE PROTEASE;

ENZYME INHIBITION;

CHYMOTRYPSIN A; SERINE PROTEINASE INHIBITOR;

ARTICLE; CONFORMATIONAL TRANSITION; DRUG CONFORMATION; DRUG DESIGN; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; PROTEINASE INHIBITION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CHYMOTRYPSIN; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDES; DRUG DESIGN; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION; SERINE PROTEINASE INHIBITORS;

EID: 0033057870     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0282(1999)51:1<9::AID-BIP3>3.0.CO;2-5     Document Type: Article

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