Enhancement of constrictor response of spastic coronary arteries to acetylcholine but not to phenylephrine in patients with coronary spastic angina

Journal of Cardiovascular Pharmacology

Volumn 33, Issue 3, 1999, Pages 414-419

  Kugiyama, Kiyotaka ^a   Ohgushi, Masamichi ^a   Motoyama, Takeshi ^a   Sugiyama, Seigo ^a   Soejima, Hirofumi ^a   Matsumura, Toshiyuki ^a   Yoshimura, Michihiro ^a   Ogawa, Hisao ^a   Yasue, Hirofumi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Acetylcholine; Coronary vasospasm; Phenylephrine; Vasoconstriction

Indexed keywords

ACETYLCHOLINE; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; PHENYLEPHRINE;

ADULT; AGED; ANGINA PECTORIS; ANGIOCARDIOGRAPHY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY SPASM; DRUG EFFECT; DRUG RESPONSE; DRUG SCREENING; FEMALE; HEART MUSCLE ISCHEMIA; HUMAN; MALE; PRIORITY JOURNAL;

ACETYLCHOLINE; ADULT; AGED; ANGINA PECTORIS, VARIANT; CORONARY ANGIOGRAPHY; CORONARY VASOSPASM; CORONARY VESSELS; FEMALE; HEMODYNAMIC PROCESSES; HUMANS; MALE; MIDDLE AGED; NITROGLYCERIN; PHENYLEPHRINE; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 0033057713     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199903000-00011     Document Type: Article

References (21)

1. Yasue H, Omote S, Takizawa A, Nagano M. Coronary arterial spasm in ischemic heart disease and its pathogenesis. Circ Res 1983;52(suppl I):147-52.
2. Maseri A, Severi S, De Nes DM, et al. "Variant" angina: one aspect of a continuous spectrum of vasospastic myocardial ischemia. Am J Cardiol 1978;42:1019-35.
3. Yasue H, Horio Y, Nakamura N, et al. Induction of coronary artery spasm by acetylcholine in patients with variant angina: possible role of the parasympathetic nervous system in the pathogenesis of coronary artery spasm. Circulation 1986;74:955-63.
4. Fukai T, Egashira K, Hata H, et al. Serotonin-induced coronary spasm in a swine model: a minor role of defective endothelium-derived relaxing factor. Circulation 1993;88(part 1):1922-30.
5. Hackett D, Larkin S, Chierchia S, Davies G, Kaski JC, Maseri A. Induction of coronary artery spasm by a direct local action of ergonovine. Circulation 1987;75:577-82.
6. 1 receptor stimulation on coronary artery diameter in patients with variant angina: comparison with effect of acetylcholine. J Am Coll Cardiol 1991;17:338-15.
7. Kugiyama K, Murohara T, Yasue H, et al. Increased constrictor response to acetylcholine of the isolated coronary arteries from patients with variant angina. Int J Cardiol 1995;52:223-33.
8. Yokoyama M, Akita H, Hirata K, et al. Supersensitivity of isolated coronary artery to ergonovine in a patient with variant angina. Am J Med 1990;89:507-15.
9. Yasue H, Touyama M, Shimamoto M, Kato H, Tanaka S, Akiyama F. Role of autonomic nervous system in the pathogenesis of Prinzmetal's variant form of angina. Circulation 1974;50:534-9.
10. Yasue H, Touyama M, Kato H, Tanaka S, Akiyama F. Prinzmetal's variant form of angina as a manifestation of alpha-adrenergic receptor-mediated coronary artery spasm: documentation by coronary arteriography. Am Heart J 1976;91:148-55.
11. Cocks TM, Angus JA. Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotonin. Nature 1983;305:627-30.
12. Murohara T, Yasue H, Ohgushi M, Sakaino N, Jougasaki M. Age related attenuation of the endothelium dependent relaxation to noradrenaline in isolated pig coronary arteries. Cardiovasc Res 1991;25:1002-9.
13. Robenson RM, Bernard YD, Carr K, Robertson D. Alpha-adrenergic blockade in vasotonic angina: lack of efficacy of specific alphal-receptor blockade with prazosin. J Am Coll Cardiol 1983;2:1146-50.
14. Chierchia S, Davies G, Berkenboom G, Crea F, Crean P, Maseri A. α-Adrenergic receptors and coronary spasm: an elusive link. Circulation 1984;69:8-14.
15. Kugiyama K, Yasue H, Ogawa H, et al. Nitric oxide activity is deficient in spasm arteries of patients with coronary spastic angina. Circulation 1996;94:266-72.
16. Okumura K, Yasue H, Matsuyama K, et al. Diffuse disorder of coronary artery vasomotility in patients with coronary spastic angina: hyperreactivity to the constrictor effects of acetylcholine and the dilator effects of nitroglycerin. J Am Coll Cardiol 1996;27:45-52.
17. Nichols AB, Gabrieli CFO, Fenoglio JJ, Esser PD. Quantification of relative coronary arterial stenosis by videodensitometric analysis of the coronary angiograms. Circulation 1984;69:512-22.
18. Vita JA, Treasure CB, Yeung AC, et al. Patients with evidence of coronary endothelial dysfunction as assessed by acetylcholine infusion demonstrate marked increase in sensitivity to constrictor effects of catecholamines. Circulation 1992;85:1390-7.
19. Coffman JD, Cohen RA. Role of alpha-adrenoreceptor subtypes mediating sympathetic vasoconstriction in human digits. Eur J Clin Invest 1988;18:309-13.
20. Vanhoutte PM. The endothelium: modulator of vascular smooth muscle tone. N Engl J Med 1988;319:512-3.
21. Bassenge E. Coronary vasomotor responses: role of endothelium and nitrovasodilators. Cardiovasc Drugs Ther 1994;8:600-12.