On-line monitoring of radiotherapy beams: Experimental results with proton beams

Medical Physics

Volumn 26, Issue 6, 1999, Pages 992-1006

  Litzenberg, Dale W ^a   Roberts, D A ^a   Lee, M Y ^a   Pham, K ^a   Vander Molen, A M ^a   Ronningen, R ^a   Becchetti, F D ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Isotopic imaging; Nuclear activation; Proton radiotherapy; Range verification

Indexed keywords

GAMMA RAYS; IMAGE RESOLUTION; IMAGING SYSTEMS; ISOTOPES; POSITRONS; PROTON BEAMS; RADIOTHERAPY; TISSUE;

ELEMENTAL COMPOSITIONS; NUCLEAR ACTIVATION; PROTON RADIOTHERAPY; RADIOISOTOPIC IMAGING; RANGE VERIFICATIONS; RESOLUTION LIMITS; SECONDARY NEUTRONS; TISSUE COMPOSITION;

PROTON BEAM THERAPY;

CARBON 11; FLUORINE 18; NITROGEN 13; OXYGEN 15;

ARTICLE; BEAM THERAPY; CANCER RADIOTHERAPY; DIAGNOSTIC IMAGING; DOSIMETRY; IMAGE QUALITY; NEUTRON; POSITRON; PRIORITY JOURNAL; PROTON RADIATION; SCINTISCANNING;

EID: 0033057538     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.598491     Document Type: Article

References (53)

1. P. L. Petti, "Differential-pencil-beam dose calculations for charged particles," Med. Phys. 19, 137-149 (1992).
2. M. Goitein, "The measurement of tissue heterodensity to guide charged particle radiotherapy," Int. J. Radiat. Oncol., Biol., Phys. 3, 27-33 (1977).
3. M. Goitein and J. M. Sisterson, "The influence of thick inhomogeneities on charged particle beams," Radiat. Res. 74, 217-230 (1978).
4. M. Goitein, "Compensation for inhomogeneities in charged particle radiotherapy using computed tomography," Int. J. Oncol., Biol., Phys. 4, 499-508 (1978).
5. A. A. Mustafa and D. F. Jackson, "The relation between X-ray CT numbers and charged particle stopping powers and its significance for radio-therapy treatment planning," Phys. Med. Biol. 28, 169-176 (1983).
6. E. L. Alpen, W. Saunders, A. Chatterjee, J. Llacer, G. T. Y. Chen, and J. Scherer, "A comparison of water equivalent thickness measurements: CT method vs heavy ion beam technique," Br. J. Radiol. 58, 542-548 (1985).
7. C. A. Tobias, "Analysis of microcomposition of biological tissue by means of induced radioactivity," Science 109, 109-113 (1949).
8. M. V. Mayneord, J. H. Martin, and D. A. Layne, "Production of radio-activity in animal tissues by high-energy X-rays," Nature (London) 164, 728-730 (1949).
9. W. L. Hughes, G. H. Nussbaum, R. Connolly, B. Emami, and P. Reilly, "Tissue perfusion rate determined from the decay of oxygen-15 activity after photon activation in situ," Science 204, 1215-1216 (1979).
10. 15O decay studies of tumor blood flow," Med. Phys. 8, 324-336 (1981).
11. 15O induced in the mouse by 175 MeV protons," Acta Radiol.: Ther., Phys., Biol. 14, 113-126 (1975).
12. G. W. Bennett, J. O. Archambeau, B. E. Archambeau, J. I. Meltzer, and C. L. Wingate, "Visualization and transport of positron emission from proton activation in vivo," Science 200, 1151-1152 (1978).
13. R. K. Ten Haken, M. Awschalom, and I. Rosenberg, "Activation of the major constituents of tissue and air by a fast neutron radiation therapy beam," Med. Phys. 10, 636-641 (1983).
14. M. C. Taylor, "Pion cancer therapy: Positron activity as an indicator of depth-dose," Science 169, 377-378 (1970).
15. L. F. Mausner, M. A. Moinester, J. D. Knight, S. Cochavi, and S. S. Friedland, "in vivo beam localization by positron activation in pion therapy," Radiat. Res. 80, 10-23 (1979).
16. H. Shirato, R. Harrison, R. O. Kornelsen, G. K. Y. Lam, C. C. Gaffney, G. B. Goodman, E. Grochowski, and B. Pate, "Detection of pion-induced radioactivity by autoradiography and positron emission tomography," Med. Phys. 16, 388-345 (1989).
17. H. D. Maccabee, U. Madhvanath, and M. R. Raju, "Tissue activation studies with alpha-particle beams," Phys. Med. Biol. 14, 213-224 (1969).
18. 20Ne beams," Med. Phys. 17, 151-157 (1990).
19. W. Enghardt, W. D. Fromm, H. Geissel, H. Heller, G. Kraft, A. Magel, P. Manfrass, G. Munzenberg, F. Nickel, J. Pawelke, D. Schardt, C. Scheidenberger, and Sobiella, "The spatial distribution of positron-emitting nuclei generated by relativistic light ion beams in organic matter," Phys. Med. Biol. 37, 2127-2131 (1992).
20. S. M. Seltzer, "An assessment of the role of charged secondaries from nonelastic nuclear interactions by therapy proton beams in water," National Institute of Standards and Technology report NISTIR 5221, June, 1993.
21. R. F. Laitano, M. Rosetti and M. Frisoni, "Effects of nuclear interactions on energy and stopping power in proton beam dosimetry," Nucl. Instrum. Methods Phys. Res. A 376, 446-476 (1996).
22. 15O activation in proton-radiation therapy," Nucl. Instrum. Methods 125, 333-338 (1975).
23. R. Loevinger and M. Berman, "A formalism for calculation of absorbed dose from radionuclides," Phys. Med. Biol. 13, 205-217 (1976).
24. J. Llacer, A. Chatterjee, E. L. Alpen, W. Saunders, S. Andreae, and H. C. Jackson, "Imaging by injection of accelerated radioactive particle beams," IEEE Trans. Med. Imaging 3, 80-90 (1984).
25. D. W. Litzenberg, J. F. Bajema, F. D. Becchetti, J. A. Brown, R. S. Raymond, D. A. Roberts, J. Caraher, G. Hutchins, R. Ronningen, R. Smith, and M. Abbott, "On-line monitoring and PET imaging of proton radiotherapy beams," IEEE Med. Imag. Conf. Rec., pp. 954-956, Orlando, FL, 25-31, Oct. 1992.
26. D. W. Litzenberg, J. F. Bajema, F. D. Becchetti, D. A. Roberts, R. Ronningen, A. M. Vander Molen, J. A. Brown, R. K. Ten-Haken, J. Caraher, C. Hazard, and M. Chawla, "On-line monitoring and P.E.T. imaging of proton radiotherapy beams," IEEE Med. Imag. Conf. Rec. pp. 1672-1676, Norfolk, VA, Oct. 30-Nov. 5, 1994.
27. S. Vynckier, S. Derreumaux, F. Richard, A. Bol, C. Michel, and A. Wambersie, "Is it possible to verify directly a proton-treatment plan using positron emission tomography," Radiother. Oncol. 26, 275-277 (1993).
28. A. M. J. Paans and J. M. Schippers, "Proton therapy in combination with PET as monitor: A feasibility study," IEEE Trans. Nucl. Sci. 40, 1041-1044 (1993).
29. U. Oelfke, G. K. Y. Lam, and M. S. Atkins, "Proton dose monitoring with PET: Quantitative studies in Lucite," Phys. Med. Biol. 41, 177-196 (1996).
30. J. Pawelke, L. Byars, W. Enghardt, W. D. Fromm, H. Geissel, B. G. Hasch, K. Lauckner, P. Manfrass, D. Schardt, and M. Sobiella, "The investigation of different cameras for in-beam PET imaging," Phys. Med. Biol. 41, 279-296 (1996).
31. A. Del Guerra and G. Di Domenico, "Positron Emission Tomography as an aid to in vivo dosimetry for proton radiotherapy: A Monte Carlo simulation," TERA 93/10 TRA 9, Aug. 1993.
32. M. G. Albouy, J. P. Cohen, M. Gusakow, N. Poffe, H. Sergolle, and L. Valentine, "Spallation de l'oxygene par besprotons de 20 a 150 MeV," Phys. Lett. 2, 306-307 (1962).
33. D. W. Litzenberg, F. D. Becchetti, and D. A. Roberts, "On-line PET monitoring of radiotherapy beams: Image reconstruction and monte carlo simulations of detector geometries," IEEE Trans. Nucl. Sci. 44, 1646-1657 (1997).
34. D. W. Litzenberg, F. D. Becchetti, D. A. Roberts, A. M. Vander Molen, and Ron Fox, "A parallel, transputer-based data acquisition system for on-line PET imaging of proton and gamma-ray radiotherapy beams," IEEE Trans. Nucl. Sci. 43, 154-158 (1996).
35. D. W. Litzenberg, "On-line monitoring and PET imaging of the positron-emitting activity created in tissue by proton radiotherapy beams," Ph.D. dissertation, University of Michigan (1997).
36. H. Stark and J. W. Woods, Probability, Random Processes and Estimation Theory for Engineers, 2nd ed. (Prentice Hall, New Jersey, 1994), p. 251.
37. P. R. Bevington and D. K. Robinson, Data Reduction and Error Analysis for the Physical Sciences, 2nd ed. (McGraw-Hill, New York, 1992), pp. 194-219.
38. ICRU, "Tissue substitutes in radiation dosimetry and measurement," Report 44 of the International Commission on Radiation Units and Measurements (Bethesda, MD, 1989).
39. 19Ne radioactive nuclei from (p,n) reactions up to 30 MeV," Phys. Rev. C 42, 748-752 (1990).
40. M. B. Chadwick and P. G. Young, "Proton nuclear interactions up to 250 MeV for radiation transport simulations of particle therapy," Proceedings of the PTCOG Conference to be published in Journal of Endocurietherapy/Hyperthermia Oncology, Detroit, 1996.
41. P. G. Young, E. D. Arthur and M. B. Chadwick, "Comprehensive nuclear model calculations: Introduction to the theory and use of the GNASH code," Los Alamos National Laboratory document LA-12343-MS (1992).
42. R. Eilbert, "Bone calcium determination in vivo by proton activation analysis," Ph.D. dissertation, Harvard University (1975).
43. 14N," Nucl. Sci. Eng. 123, 1-16 (1996).
44. M. B. Chadwick and P. G. Young, "Calculation and evaluation of cross sections and kerma factors for neutrons up to 100 MeV on carbon," Nucl. Sci. Eng. 123, 17-37 (1996).
45. M. J. Inwood, S. Thomson, and N. J. Bryant, "Hematology," Philadelphia: in Lynch's Medical Laboratory Technology, 4th ed. edited by S. S. Raphael (W. B. Saunders, 1983), pp. 625-627.
46. J. L. Romero, J. H. Osborne, F. P. Brady, W. Caskey, D. A. Cebra, M. D. Partlan, B. H. Kusko, R. S. King, I. Mirshad, H. Kubo, I. Daftari, and W. Chu, "Patient positioning for protontherapy using a proton range telescope," Nucl. Instrum. Methods Phys. Res. A 356, 558-565 (1995).
47. J. M. Balter, K. L. Lam, H. M. Sandler, J. F. Littles, R. L. Bree, and R. K. Ten Haken, "Automated localization of the prostate at the time of treatment using implanted radiopaque markers: Technical feasibility," Int. J. Radiat. Oncol., Biol., Phys. 33, 1281-1286 (1995).
48. M. J. Berger and S. M. Seltzer, "Tables of energy loss and ranges of electrons and positrons," in Studies in Penetration of Charged Particles in Matter, edited by U. Fano, Publ. No. 1133 (National Academy of Sciences, National Research Council, Washington D.C., 1956), pp. 1-30.
49. J. F. Janni, "Proton range-energy tables, 1 keV-10 GeV," At. Data Nucl. Data Tables 27, (1982).
50. 11C reaction from 50 to 160 MeV," Nucl. Phys. 78, 476-480 (1966).
51. 11C produced in nitrogen by low-energy protons," Phys. Rev. C 3, 2167-2171 (1971).
52. L. Valentin, G. Albouy, J. P. Cohen, and M. Gusakow, "Fonctions d'excitation des reactions (p.pn) et (p.2p 2n) dans les noyaux legers entre 15 et 155 MeV," J. Phys. (France) 25, 704-706 (1964).
53. A. B. Clegg, "Gamma radiation from medium energy proton bombardment of lithium, beryllium, boron, carbon and nitrogen," Proc. Phys. Soc. 78, 681 (1961).