Proliferation of human peripheral blood mononuclear cells during calcium entry blockade. Role of protein kinase C

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 21, Issue 4, 1999, Pages 253-259

  Lijnen, Paul ^a,b   Petrov, Victor ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Calcium; Mibefradil; Mononuclear cells; Nifedipine; Proliferation

Indexed keywords

MIBEFRADIL; NIFEDIPINE; PROTEIN KINASE C;

ADULT; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL PROLIFERATION; DRUG EFFECT; ENZYME ACTIVITY; GROWTH REGULATION; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MALE; MITOGENESIS; MONONUCLEAR CELL;

ADULT; BENZIMIDAZOLES; CALCIUM CHANNEL BLOCKERS; CELL DIVISION; CONCANAVALIN A; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; L-LACTATE DEHYDROGENASE; LEUCINE; LEUKOCYTES, MONONUCLEAR; MALE; MIBEFRADIL; NIFEDIPINE; PROTEIN KINASE C; PYRIMIDINE NUCLEOSIDES; TETRADECANOYLPHORBOL ACETATE; TETRAHYDRONAPHTHALENES; THYMIDINE; URIDINE;

EID: 0033057364     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.1999.21.4.538173     Document Type: Article

References (41)

1. Altman, A., Coggeshall, K.M., Mustelin, T. Transmembrane signaling pathways during T-cell activation. Adv Immunol 1990, 48: 227-360.
2. Ullman, K.S., Northrop, J.P., Verweij, C.L., Crabtree, G.R. Transmission of signals from the T-lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: The missing link. Ann Rev Immunol 1990, 8: 421-52.
3. Imboden, J.B., Stobo, J.D. Transmembrane signaling by the T-cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and release calcium ions from intracellular stores. J Exp Med 1985, 161: 446-56.
4. Kishimoto, A., Takai, Y, Mori, T., Kikkawa, V., Nishizuka, Y. Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidyl-inositol turnover. J Biol Chem 1980, 255: 2273-6.
5. Kaibuchi, K., Takai, Y., Nishizuka, Y. Protein kinase C and calcium ion in mitogenic response of macrophage-depleted human peripheral lymphocytes. J Biol Chem 1985, 260: 1366-9.
6. Manger, B., Weiss, A., Imboden, J., Laing, T., Stobo, J.D. The role of protein kinase C in transmembrane signaling by the T-cell antigen receptor complex. Effects of stimulation with soluble or immobilized CD3 antibodies. J Immunol 1987, 139: 2755-60.
7. Nel, A.E., Bouic, P., Lattanze, G.R. et al. Reaction of T-lymphocytes with anti-T3 induces translocation of C-kinase activity to the membrane and specific substrate phosphorylation. J Immunol 1987, 138: 3519-24.
8. Isakov, N., Altman, A. Human T-lymphocyte activation by tumor promoters: Role of protein kinase C. J Immunol 1987, 138: 3100-7.
9. Shackelford, D.A., Trowbridge, I.S. Induction of expression and phosphorylation of the human interleukin-2 receptor by a phorbol diester. J Biol Chem 1984, 245: 11706-12.
10. Chatila, T.A., Geha, R.S. Phosphorylation of T-cell membrane proteins by activators of protein kinase C. J Immunol 1988, 140: 4308-14.
11. Isakov, N., Mally, M.I., Altman, A. Mitogen-inducedhuman T-cell proliferation associated with increased expression of selected PKC genes. Mol Immunol 1992, 29: 927-33.
12. Lichtmann, A.H., Segel, G.B., Lichtmann, M.A. The role of calcium in lymphocyte proliferation. Blood 1983, 81: 413-22.
13. Whitney, R.B., Sutherland, R.M. Requirement for calcium ions in lymphocyte transformation stimulated by phytohemagglutin. J Cell Physiol 1972, 80: 329-37.
14. Kay, J.E. Interaction of lymphocytes and phytohaemagglutinin: Inhibition by chelating agents. Cell Res 1971, 68: 11-6.
15. Allwood, G., Asherson, G.L., Davey, M.J., Goodford, P.J. The early uptake of radioactive calcium by human lymphocytes treated with phytohaemagglutinin. Immunology 1971, 21: 509-16.
16. Whitney, R.B., Sutherland, R.M. Enhanced uptake of calcium by transforming lymphocytes. Cell Immunol 1972, 5: 137-47.
17. Parker, C.W. Correlation between mitogenicity and stimulation of calcium uptake in human lymphocytes. Biochem Biophys Res Commun 1974, 61: 1180-6.
18. Luckasen, J.R., White, J.G., Kersey, J.H. Mitogenic properties of a calcium ionophore A23187. Proc Natl Acad Sci USA 1974, 71: 5088-90.
19. Bühler, F.R., Fleckenstein-Grün, G. A new class of calcium antagonists: From molecular biology to clinical benefit. J Cardiovasc Pharmacol 1996, 27: S1-26.
20. Lijnen, P., Saavedra, A., Petrov, V. In vitro proliferate response of human peripheral blood mononuclear cells to concanavalin A. Clin Chim Acta 1997, 264: 91-101.
21. Korzeniewski, C., Callewaert, D.M. An enzyme-release assay for natural cyclotoxicity. J Immunol Meth 1983, 64: 313-20.
22. Stevens, C., Lipman, M., Fabry, S. et al. 5-Aminosalicylic acid abrogates T-cell proliferation by blocking interleukin-2 production in peripheral blood mononuclear cells. J Pharmacol Exp Ther 1995, 272: 399-406.
23. Gillies, R.J., Diedier, N., Denton, M. Determination of cell number in monolayer cultures. Annals Biochem 1986, 159: 109-13.
24. Schmitt, R., Clozel, J.P., Iberg, N., Bahler, F.R. Mibefradil prevents neointima formation after vascular injury in rats. Arterioscler Thromb Vasc Biol 1995, 15: 1161-5.
25. Hérembert, T., Zhu, D.L., Marche, P. Mechanism of action of the inhibitory effect of nifedipine on the growth of cultured aortic cells from spontaneously hypertensive and normotensive rats. Br J Pharmacol 1995, 114: 1703-9.
26. Jackson, C.L., Schwanz, S.M. Pharmacology of smooth muscle replication. Hypertension 1992, 20: 713-36.
27. Uehara, Y., Kawataba, Y., Hirawa, N. et al. OPC-13340, a new dihydropyridine calcium channel blocker attenuates rapid vascular smooth muscle cells growth in spontaneously hypertensive rats. J Cardiovasc Pharmacol 1992, 20: 408-15.
28. Witkowski, J.M., Siebert, J., Lukaszuk, K., Trawicka, L. Comparison of the effect of a panel of membrane channel blockers on the proliferate, cytotoxic and cytoadherence abilities of human peripheral blood lymphocytes. Immunopharmacology 1993, 26: 53-63.
29. Castagna, M., Takai, Y., Kaibuchi, K., Sano, K., Kikkawa, U., Nishizuka, Y. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J Biol Chem 1982, 257: 7847-51.
30. Kruijer, W., Cooper, J.A., Hunter, T., Verma, I.M. Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein. Nature 1984, 312: 711-6.
31. Greenberg, M.E., Ziff, E.B. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature 1984, 311: 343-8.
32. Ryder, K., Nathans, D. Induction of proto-oncogene c-jun by serum growth factors. Proc Natl Acad Sci USA 1988, 85: 8464-7.
33. Lamp, W.W., Wamsley, P., Sassone-Corsi, P., Verma, I.M. Induction of proto-oncogene JUN/AP-1 by serum and TPA. Nature 1988, 334: 629-31.
34. Halazonetis, T.D., Georgopoulos, K., Greenberg, M.E., Leder, P. c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell 1988, 55: 917-24.
35. Chiu, R., Boyle, W.J., Meek, J., Smeal, T., Hunter, T., Karin, M. The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell 1988, 54: 541-52.
36. Rauscher, F.J., Voulalas III, P.J., Franza, B.R. Jr., Curran, T. Fos and Jun bind cooperatively to the Ap-1 site: Reconstitution in vitro. Genes Dev 1988, 2: 1687-99.
37. Tamir, A., Isakov, N. Increased intracellular cyclic AMP levels block PKC-mediated T-cell activation by inhibition of c-jun transcription. Immunol Lett 1991, 27: 95-100.
38. Lee, W., Mitchell, P., Tjian, R. Purified transcription factor AP-1 interacts with TPA inducible enhancer elements. Cell 1987, 49: 741-52.
39. Angel, P., Imagawa, M., Chiu, R. et al. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated transacting factor. Cell 1987, 49: 729-39.
40. May, C.L., Southworth, A.J., Calder, P.C. Inhibition of lymphocyte protein kinase C by unsaturated fatty acids. Biochem Biophys Res Commun 1993, 195: 823-8.
41. Gelfand, E.W., Cheung, R.K., Grinstein, S., Mills, G.B. Characterization of the role of calcium influx in mitogen-induced triggering of human T-cells. Identification of calcium dependent and calcium-independent signals. Eur J Immunol 1986, 16: 907-12.