Chemokine-induced phosphorylation of CC chemokine receptor 5 (CCR5)

Journal of Leukocyte Biology

Volumn 65, Issue 3, 1999, Pages 281-285

  Olbrich, Heike ^c   Proudfoot, Amanda E I ^a   Oppermann, Martin ^b  

^a SERONO PHARMACEUTICAL RES INSTITUTE   (Switzerland)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c NONE

Author keywords

ANTES; AOP RANTES; Desensitization; Phosphorylation sites

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CCR5; CLATHRIN; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 8; LIGAND; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MESSENGER RNA; PHOSPHOTRANSFERASE; PROTEIN KINASE C; RANTES; RETINA S ANTIGEN;

CELL ACTIVATION; DESENSITIZATION; ENDOCYTOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOBLOTTING; LIGAND BINDING; MACROPHAGE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0033057328     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.65.3.281     Document Type: Review

References (37)

1. Baggiolini, M. (1998) Chemokines and leukocyte traffic. Nature 392, 565-568.
2. Wells, T. N., Power, C. A., Proudfoot, A. E. (1998) Definition, function and pathophysiological significance of chemokine receptors. Trends Pharmacol. Sci. 19, 376-380.
3. Deng, H. K., Liu, R., Ellmeier, W., Choe, S., Unutmaz, D., Burkhart, M., Di Marzio, P., Marmon, S., Sutton, R. E., Hill, C. M., Davis, C. B., Peiper, S. C., Schall, T. J., Littman, D. R., Landau, N. R. (1996) Identification of a major co-receptor for primary isolates of HIV-1. Nature 381, 661-666.
4. + cells is mediated by the chemokine receptor CC-CKR-5. Nature 381, 667-673.
5. Alkhatib, G., Combadiere, C., Broder, C. C., Feng, Y., Kennedy, P. E., Murphy, P. M., Berger, E. A. (1996) CC CKR5: A RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272, 1955-1958.
6. Feng, Y., Broder, C. C., Kennedy, P. E., Berger, E. A. (1996) HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272, 872-877.
7. + T cells. Science 270, 1811-1815.
8. Proudfoot, A. E., Power, C. A., Hoogewerf, A. J., Montjovent, M. O., Borlat, F., Offord, R. E., Wells, T. N. (1996) Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist. J. Biol. Chem. 271, 2599-2603.
9. Gong, J. H., Uguccioni, M., Dewald, B., Baggiolini, M., Clark-Lewis I. (1998) RANTES and MCP-3 antagonists bind multiple chemokine receptors. J. Biol. Chem. 271, 10521-10527.
10. Simmons, G., Clapham, P. R., Picard, L., Offord, R. E., Rosenkilde, M. M., Schwartz, T. W., Buser, R., Wells, T. C., Proudfoot, A. E. (1997) Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist. Science 276, 276-279.
11. Mack, M., Luckow, B., Nelson, P. J., Cihak, J., Simmons, G., Clapham, P. R., Signoret, N., Marsh, M., Stangassinger, M., Borlat, F., Wells, T. N., Schlöndorff, D., Proudfoot, A. E. (1998) Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity. J. Exp. Med. 187, 1215-1224.
12. Krupnick, J. G., Benovic, J. L. (1998) The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu. Rev. Pharmacol. Toxicol. 38, 289-319.
13. Goodman, O. B., krupnick, J. G., Santini, F., Gurevich, V. V., Penn, R. B., Gagnon, A. W., Keen, J. H., Benovic, J. L. (1996) β-Arrestin as a clathrin adaptor in endocytosis of the β2-adrenergic receptor. Nature 383, 447-450.
14. Ferguson, S. S., Downey, W. E., Colapietro, A. M., Barak, L. S., Menard, L., Caron, M. G. (1996) Role of β-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. Science 271, 363-366.
15. Aramori, I., Zhang, J., Ferguson, S. S., Bieniasz, P. D., Cullen, B. R., Caron, M. G. (1997) Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor. EMBO J. 16, 4606-4616.
16. Ben-Baruch, A., Michiel, D. F., Oppenheim, J. J. (1995) Signals and receptors involved in recruitment of inflammatory cells. J. Biol. Chem. 270, 11703-11706.
17. Oppermann, M., Proudfoot, A. E. I., Olbrich, H. (1999) Differentiated effects of CC chemokines on CC chemokine receptor CCR5 phosphorylation and identification of phosphorylation sites on the CCR5 carboxylterminus. J. Biol. Chem., in press.
18. Benovic, J. L., Staniszewski, C., Mayor, F., Caron, M. G., Lefkowitz, R. J. (1988) β-Adrenergic receptor kinase. Activity of partial agonists for stimulation of adenylate cyclase correlates with ability to promote receptor phosphorylation. J. Biol. Chem. 263, 3893-3897.
19. Yu, Y., Zhang, L., Yin, X., Sun, H., Uhl, G. R., Wang, J. C. (1997) p Opioid receptor phosphorylation, desensitization, and ligand efficacy. J. Biol. Chem. 272, 28869-28874.
20. Samson, M., Labbe, O. Mollereau, C., Vassart, G., Parmentier, M. (1996) Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochem. 35, 3362-3367.
21. Raport, C. J., Gosling, J., Schweickart, V. I., Gray, P. W., Charo, I. F. (1996) Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha. J. Biol. Chem. 271, 17161-17166.
22. Bacon, K. B., Premack, B. A., Gardner, P., Schall, T. J. (1995) Activation of dual T cell signaling pathways by the chemokine RANTES. Science 269, 1727-1730.
23. Roth, N. S., Campbell, P. T., Caron, M. G., Lefkowitz, R. J., Lohse, M. J. (1991) Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA 88, 6201-6204.
24. Oppermann, M., Freedman, N. J., Alexander, R. W., Lefkowitz, R. J. (1996) Phosphorylation of the type IA angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C. J. Biol. Chem. 271, 13266-13272.
25. Bleul, C. C., Wu, L., Hoxie, J. A., Springer, T. A., Mackay, C. R. (1997) The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T Lymphocytes. Proc. Natl. Acad. Sci. USA 94, 1925-1930.
26. Tuttle, D. L., Harrison, J. K., Anders, C., Sleasman, J. W., Goodenow, M. M. (1998) Expression of CCR5 increases during monocyte differentiation and directly mediates macrophage susceptibility to infection by human immunodeficiency virus type 1. J. Virol. 72, 4962-4969.
27. de Blasi, A., Parruti, G., Sallese, M. (1995) Regulation of G protein-coupled receptor kinase subtypes in activated T lymphocytes. Selective increase of beta adrenergic receptor kinase 1 and 2. J. Clin. Invest. 95, 203-210.
28. Haribabu, B., Snyderman, R. (1993) Identification of additional members of human G protein-coupled receptor kinase multigene family. Proc. Natl. Acad. Sci. USA 90, 9398-9402.
29. Ohguro, H., Palczewski, K., Ericsson, L. H., Walsh, K. A., Johnson, R. S. (1993) Sequential phosphorylation of rhodopsin at multiple sites. Biochemistry 32, 5718-5724.
30. Giannini, E., Brouchon, L., Boulay, F. (1995) Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo. J. Biol. Chem. 270, 19166-19172.
31. Prossnitz, E. R., Kim, C. M., Benovic, J. L., Ye, R. D. (1995) Phosphorylation of the N-formyl peptide receptor carboxyl terminus by the G protein-coupled receptor kinase, GRK2. J. Biol. Chem. 270, 1130-1137.
32. Diviani, D., Lattion, A. L., Cotecchia, S. (1997) Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the alpha1B-adrenergic receptor. J. Biol. Chem. 272, 28712-28719.
33. Eason, M. G., Moreira, S. P., Liggett, S. B. (1995) Four consecutive serines in the third intracellular loop are the sites for beta-adrenergic receptor kinase-mediated phosphorylation and desensitization of the alpha 2A-adrenergic receptor. J. Biol. Chem. 270, 4681-4688.
34. Franci, C., Gosling, J., Tsou, C. L., Coughlin, S. R., Charo, I. F. (1996) Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor. Critical role of carboxyl-tail serines/threonines in receptor function. J. Immunol. 157, 5606-5612.
35. Richardson, R. M., DuBose, R. A., Ali, H., Tomhave, E. D., Haribabu, B., Snyderman, R. (1995) Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions. Biochemistry 34, 14193-14201.
36. Mueller, S. G., Schraw, W. P., Richmond, A. (1994) Melanoma growth stimulatory activity enhances the phosphorylation of the class II interleukin-8 receptor in non-hematopoietic cells. J. Biol. Chem. 269, 1973-1980.
37. Aragay, A. M., Mellado, M., Frade, J. M., Martin, A. M., Jimenez, S. M., Martinez, A. C., Mayor, F. (1998) Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2. Proc. Natl. Acad. Sci. USA 95, 2985-2990.