Contribution of a high dose of L-ascorbic acid to carnitine synthesis in guinea pigs fed high-fat diets

Journal of Nutritional Science and Vitaminology

Volumn 45, Issue 2, 1999, Pages 163-171

  Otsuka, Megumi ^a   Matsuzawa, Miyuki ^a   Ha, Tae Youl ^b   Arakawa, Nobuhiko ^a  

^a OCHANOMIZU UNIVERSITY   (Japan)

^b Korea Food Research Institute   (South Korea)

Author keywords

Carnitine; Guinea pigs; High fat diets; L ascorbic acid; Plasma triacylglycerol

Indexed keywords

ASCORBIC ACID; CARNITINE; LARD; TRIACYLGLYCEROL;

ANIMAL CELL; ARTICLE; ASCORBIC ACID DEFICIENCY; BIOSYNTHESIS; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; GUINEA PIG; HYDROXYLATION; LIPID DIET; LIVER CELL; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALIA; CAVIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0033056615     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.45.163     Document Type: Article

References (25)

1. Maebashi M, Kawamura N, Sato M, Imamura A, Yoshinaga K. 1978. Lipid-lowering effect of carnitine in patients with type-IV hyperlipoproteinemia. Lancet 2: 805-807.
2. Orzali A, Maetzke G, Donzelli F, Rubaltelli FF. 1984. Effect of carnitine on lipid metabolism in the neonate. II. Carnitine addition to lipid infusion during prolonged total parenteral nutrition. J Pediatr 104: 436-440.
3. Davis AT, Albrecht RM, Scholten DJ, Morgan RE. 1988. Increased plasma carnitine in trauma patients given lipid-supplemented total parenteral nutrition. Am J Clin Nutr 8: 1400-1402.
4. Olson AL, Nelson SE, Rebouche CJ. 1989. Low carnitine intake and altered lipid metabolism in infants. Am J Clin Nutr 49: 624-628.
5. Rebouche CJ, Panagides DD, Nelson SE. 1990. Role of carnitine in utilization of dietary medium-chain triglycerides by term infants. Am J Clin Nutr 52: 820-824.
6. Wanner C, Wackerle B, Boeckle H, Schollmeyer P, Horl WH. 1990. Plasma and red blood cell carnitine and carnitine esters during L-carnitine therapy in hemodialysis patients. Am J Clin Nutr 51: 407-410.
7. Dayanandan A, Kumar P, Kalaiselvi T, Panneerselvam C. 1994. Effect of L-carnitine on blood lipid composition in atherosclerotic rats. J Clin Biochem Nutr 17: 81-87.
8. Hiatt WR, Nawaz D, Brass EP. 1987. Carnitine metabolism during exercise in patients with peripheral vascular disease. J Appl Physiol 62: 2383-2387.
9. Vukovich MD, Costill DL, Fink WJ. 1994. Carnitine supplementation: effect on muscle carnitine and glycogen content during exercise. Med Sci Sports Exerc 26: 1122-1129.
10. Brass EP, Scarrow AM, Ruff LJ, Masterson KA, Lunteren EV. 1993. Carnitine delays rat skeletal muscle fatigue in vitro. J Appl Physiol 75: 1595-1600.
11. Kuratsune H, Yamaguti K, Takahashi M, Tagawa S, Machii T, Kitani T. 1995. Abnormal cellular carnitine metabolism in chronic fatigue syndrome. J Immunol Immunolpharmacol 15: 40-44.
12. Cederblad G. 1987. Effect of diet on plasma carnitine levels and urinary carnitine excretion in humans. Am J Clin Nutr 45: 725-729.
13. Maccari F, Arseni A, Chiodi P, Ramacci MT, Angelucci L, Hulsmann WC. 1987. L-Carnitine effect on plasma lipoproteins of hyperlipidemic fat-loaded rats. Lipids 22: 1005-1008.
14. Ha T-Y, Otsuka M, Arakawa N. 1991. The regulatory effect of L-ascorbic acid on the carnitine synthesis in primary cultured guinea pigs hepatocytes. J Nutr Sci Vitaminol 37: 371-378.
15. Ha T-Y, Otsuka M, Arakawa N. 1994. L-Ascorbic acid indirectly stimulates fatty acid utilization in primary cultured guinea pigs hepatocytes by enhancing carnitine synthesis. J Nutr 124: 732-737.
16. Ha T-Y, Otsuka M, Arakawa N. 1990. The effect of graded doses of ascorbic acid on the tissue carnitine and plasma lipid concentration. J Nutr Sci Vitaminol 36: 227-234.
17. Rebouche CJ. 1995. Renal handling of carnitine in experimental vitamin C deficiency. Metabolism 44: 1639-1643.
18. Bobek P, Ginter E, Ozdin L, Poledne R, Potucek J. 1983. Effect of long-term marginal vitamin C deficiency on plasma triglyceride kinetics in guinea-pigs. Biomed Biochim Acta 42: 413-416.
19. Arakawa N, Ha T-Y, Otsuka M. 1989. An improved high-performance liquid chromatographic assay for the determination of free and esterified carnitine in animal tissues. J Nutr Sci Vitaminol 35: 475-479.
20. Dtadler DD, Chenard CA, Rebouche CJ. 1993. Effect of dietary macronutrient content on carnitine excretion and efficiency of carnitine reabsorption. Am J Clin Nutr 58: 868-872
21. Ruff LJ, Miller LG, Brass EP. 1991. Effect of exogenous carnitine on carnitine homeostasis in the rat. Biochim Biophys Acta 1073: 543-549.
22. Ha T-Y, Otsuka M, Arakawa N. 1993. The behavior of carnitine in primary-cultured guinea pig hepatocytes. Nippon Eiyo Shokuryo Gakkaishi (J Jpn Soc Nutr Food Sci) 46: 483-486.
23. Harris RC, Foster CV, Hultman E. 1987. Acetylcarnitine formation during intense muscular contraction in humans. J Appl Physiol 63: 440-442.
24. Englard S, Carnicero HH. 1987. γ-Butyrobetaine hydroxylation to carnitine in mammalian kidney. Arch Biochem Biophys 190: 361-364.
25. Rebouche CJ. 1991. Ascorbic acid and carnitine biosynthesis. Am J Clin Nutr 54: 1147S-1152S.