Toxicological and antioxidant effects of short-term dehydroepiandrosterone injection in young rats fed diets deficient or adequate in vitamin E

Food and Chemical Toxicology

Volumn 37, Issue 5, 1999, Pages 503-508

  Ng, Hee Poh ^a   Wang, Yong Fa ^a   Lee, Chia Yu ^a   Hu, Miao Lin ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Dehydroepiandrosterone; Glucose 6 phosphate dehydrogenase; Lipid peroxidation; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE TRANSFERASE; PRASTERONE; THIOL GROUP;

ALPHA TOCOPHEROL DEFICIENCY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENZYME ACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; LIPID PEROXIDATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; ORGAN WEIGHT; OXIDATION; RAT;

ANALYSIS OF VARIANCE; ANIMALS; ANTIOXIDANTS; DEHYDROEPIANDROSTERONE; DIET; DRUG EVALUATION, PRECLINICAL; GLUCOSEPHOSPHATE DEHYDROGENASE; GLUTATHIONE TRANSFERASE; INJECTIONS, INTRAPERITONEAL; MALE; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES; TIME FACTORS; VITAMIN E DEFICIENCY;

EID: 0033056415     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(99)00032-0     Document Type: Article

References (33)

1. Aragno M., Tamagno E., Boccuzzi G., Brignardello E., Chiarpotto E., Pizzini A., Danni O. Dehydroepiandrosterone pretreatment protects rats against the pro-oxidant and necrogenic effects of carbon tetrachloride. Biochemical Pharmacology. 46:1993;1689-1694.
2. 4-induced lipid peroxidaton in liver microsomes from DHEA-pretreated rats. Free Radical Research. 21:1994;427-435.
3. Buttriss J.L., Diplock A.T. High performance liquid chromatography methods for vitamin E in tissues. Methods in Enzymology. 105:1984;131-147.
4. Calzyme Laboratories (1991) Glutamic oxaloacetic transaminase and glutamic pyruvic transaminase. Calzyme Laboratories, Inc, San Luis Obbispo, CA.
5. Chang T.Y., Hu M-L. Concentration and lipid peroxidation in tissues and toxicity of para-aminobenzoic acid fed to rats in drinking water. Journal of Nutritional Biochemistry. 7:1996;408-413.
6. Cleary M.P. The antiobesity effect of dehydroepiandrosterone in rats. Proceedings of the Society of Experimental Biology and Medicine. 196:1991;8-16.
7. Finan A.C., Cleary M.P. Lack of an effect of short-term dehydroepiandrosterone treatment on the pentose pathway. Nutrition Research. 8:1988;755-765.
8. Ganong W. F. (1991) Review of Medical Physiology, 15th edn, pp. 395-396. Prentice-Hall International, Englewood Cliffs, NJ.
9. Gary G., Mary C.M., Levy H.R. On the mechanisms of interaction of steroids with human glucose 6-phosphate dehydrogenase. Archives of Biochemistry and Biophysics. 318:1995;25-29.
10. Goldfarb A.H., McIntosh M.K., Boyer B.T., Fatouros J. Vitamin E effects on indexes of lipid peroxidation in muscle from DHEA-treated and exercised rats. Journal of Applied Physiology. 76:1994;1630-1635.
11. Gordon G.B., Bush D.E., Weisman H.F. Reduction of atherosclerosis by administration of dehydroepiandrosterone. Journal of Clinical Investigation. 82:1988;712-720.
12. Gordon G.B., Shantz L.M., Talalay P. Modulation of growth, differentiation and carcinogenesis by dehydroepiandrosterone. Advances in Enzyme Regulation. 18:1987;857-864.
13. Glock G.E., Mclean P. Further studies on the properties and assay of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase of rat liver. Biochemical Journal. 55:1953;400-408.
14. Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferases. Journal of Biological Chemistry. 249:1974;7130-7139.
15. 10 and selenium protect tissues against lipid peroxidation in rat tissue slices. Journal of Nutrition. 120:1989;97-104.
16. McIntosh M.K., Berdanier C.D. Antiobesity effects of dehydroepiandrosterone are mediated by futile substrate cycling in hepatocytes of BHE/cdb rats. Journal of Nutrition. 121:1991;2037-2043.
17. McIntosh M.K., Berdanier C.D. Influence of dehydroepiandrosterone (DHEA) on the thyroid hormone status of BHE/cdb rats. Journal of Nutritional Biochemistry. 3:1992;194-199.
18. McIntosh M.K., Goldfarb A.H., Curtis L.N., Cote P.S. Vitamin E alters hepatic antioxidant enzymes in rats treated with dehydroepiandrosterone (DHEA). Journal of Nutrition. 123:1993;216-224.
19. Majewska M.D. Neuronal actions of DHEA. Annals of the New York Academy of Sciences. 774:1995;111-120.
20. Metzger C., Mayer D., Hoffmann H., Bocker T., Hobe G., Benner A., Bannasch P. Sequential appearance and ultrastructure of amphophilic cell foci, adenomas, and carcinomas in the liver of male and female rats treated with dehydroepiandrosterone. Toxicologic Pathology. 23:1995;591-605.
21. Mooradian A.D. Antioxidant properties of steroids. Journal of Steroid Biochemistry and Molecular Biology. 45:1993;509-511.
22. Nafziger A.N., Herrinton D.M., Bush T.L. Dehydroepiandrosterone sulfate: their relation to cardiovascular disease. Epidemiology Review. 13:1991;267-293.
23. Orentreich N., Brind J., Rizer R., Vogelman J. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. Journal of Clinical Endocrinology and Metabolism. 59:1984;551-555.
24. Rao M.S., Subbarao V., Yeldani A.V., Reddy J.K. Hepatocarcinogenicity of dehydroepiandrosterone in the rat. Cancer Research. 52:1992;2992-2997.
25. Regelson W., Kalimi M.K. Dehydroepiandrosterone (DHEA) - the multifunctional steroid. II. Effects on the CNS, cell proliferation, metabolic and vascular, clinical and other effects. Mechanism of action? Annals of the New York Academy of Sciences. 774:1995;564-576.
26. Rom W.N., Harkin T. Dehydroepiandrosterone inhibits the spontaneous release of superoxide radical by alveolar macrophages in vitro in asbestosis. Environmental Research. 55:1991;145-156.
27. Schwartz A.G., Pashko L.L. Mechanism of cancer preventive action of DHEA. Annals of the New York Academy of Sciences. 774:1995;180-186.
28. Sedlak J., Lindsay R.H. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissues with Ellman's reagent. Analytical Biochemistry. 25:1968;192-205.
29. Swierczynski J., Bannasch P., Mayer D. Increase of lipid peroxidation in rat liver microsomes by dehydroepiandrosterone feeding. Biochimica et Biophysica Acta. 1315:1996;193-198.
30. Tagliaferro A., Roman A., Meeker L. Rate of adipocyte lipolysis of rats treated with dehydroepiandrosterone. FASEB Journal. 5:1991;A956 (abstract).
31. Whitcomb J.M., Schwartz A.G. Dehydroepiandrosterone and 16α-Br-epiandrosterone inhibit 12-O-tetradecanoylphorbol-13-acetate stimulation of superoxide radical by human polymorphonuclear leukocytes. Carcinogenesis. 6:1985;333-335.
32. LAw) by dehydroepiandrosterone in rats: a possible peroxisomal proliferator. Cancer Research. 49:1989;2337-2343.
33. Yamada J., Sajuma M., Ikeda T., Fukuda K., Suga T. Characteristics of dehydroepiandrosterone as a peroxisome proliferator. Biochimica et Biophysica Acta. 1092:1991;233-243.