A physiologically based pharmacokinetic model of inorganic arsenic

Regulatory Toxicology and Pharmacology

Volumn 29, Issue 2 I, 1999, Pages 128-141

  Yu, Donghan ^a  

^a Korea Atomic Energy Research Institute   (South Korea)

Author keywords

Dose response assessment; Inorganic arsenic; PBPK model; Risk assessment

Indexed keywords

ARSENIC;

ARTICLE; BLOOD; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); ENVIRONMENTAL EXPOSURE; KINETICS; MODEL; PRIORITY JOURNAL; RISK ASSESSMENT; WATER CONTAMINATION; WATER POLLUTANT; WATER POLLUTION;

EID: 0033056023     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.1999.1282     Document Type: Article

References (15)

1. Bates, M. M., Smith, A. H., and Hopenhayn-Rich, C. (1992). Arsenic ingestion and internal cancers: A review. Am. J. Epidemiol. 135, 462-476.
2. Buchet, J. P., Lauwerys, R., and Roels, H. (1981). Comparison of the urinary excretion of arsenic metabolites after a single dose of sodium arsenite, monomethylarsenate, or dimethylarsenate in man. Int. Arch. Occup. Environ. Health 48, 71-79.
3. Chen, C. J., and Wang, C. J. (1990). Ecological correction between arsenic level in well water and age-adjusted mortality from malignant neoplasms. Cancer Res. 50, 5470-5474.
4. Chen, C. J., Chen, C. W., Wu, M. M., and Kuo, T. L. (1992). Cancer potential in liver, lung, bladder, and kidney due to ingested inorganic arsenic in drinking water. Br. J. Cancer 66, 888-892.
5. Creselius, E. A. (1977). Changes in the chemical speciation of arsenic following ingestion by man. Environ. Health Perspect. 19, 147-150.
6. D'Souza, R. W., Francis, W. R., and Andersen, M. E. (1988). Physiological model for tissue glutathione depletion and increased resynthesis after ethylene dichloride exposure. J. Pharmacol. Exp. Ther. 245, 563-568.
7. EPA (1984). Health Assessment Document for Inorganic Arsenic (Final Report), EPA/600/8-83/021F. U.S. Environmental Protection Agency, Washington, DC.
8. EPA (1988). Reference Physiological Parameters in Pharmacokinetic Modeling, EPA/600/6-88. U.S. Environmental Protection Agency, Washington, DC.
9. Farooqui, M. Y. H., and Ahmed, A. H. (1984). Circadian perodicity of tissue glutathione and its relationship with lipid peroxidation in rats. Life Sci. 34, 2413-2418.
10. Fowler, B. A. (Ed.) (1983). Biological and Environmental Effects of Arsenic: Topics in Environmental Health, Vol. 6, Ch. 5. Elsevier, Amsterdam.
11. Georis, B., Cardenedas, A., Buchet, J. P., and Lauwerys, R. (1990). Inorganic arsenic methylation by rat tissue slices. Toxicology 63, 73-84.
12. Husain, S., and Ahmed, K. M. (1991). Tissue glutathione levels in mice treated with delta-9-terathydrocannabinol. Pharmacol. Biochem. Behav. 40, 513-515.
13. Jaeschke, H., and Wendel, A. (1985). Diurnal fluctuation and pharmacological alternation of mouse organ glutathione content. Biochem. Pharmacol. 34, 1029-1033.
14. Johnson, L. R., and Farmer, J. G. (1991). Use of human metabolic studies and urinary arsenic speciation in assessing arsenic exposure. Bull. Environ. Contam. Toxicol. 46, 53-61.
15. Meister, A. (1988). Chapter 23: Glutathione. In The Liver: Biology and Pathobiology (I. M. Arias, W. B. Jakoby, H. P. Popper, D. Schachter, and D. A. Shafritz, Eds.), second ed., pp. 401-417. Raven Press, New York.