Synthesis and in vitro biological activity of 4α(2-propenyl)-5α- cholest-24-en-3α-ol: A 24,25-dehydro analog of the hypocholesterolemic agent 4α-(2-propenyl)-5α-cholestan-3α-ol

Steroids

Volumn 64, Issue 3, 1999, Pages 217-227

  Lin, Ho Shen ^a   Rampersaud, Ashraff A ^a   Richett, Michael E ^a   Harper, Richard W ^a   Beavers, Lisa S ^a   McClure, Don B ^a   Gardner, Anthony J ^a   Eacho, Patrick I ^a   Foxworthy, Patricia S ^a   Gadski, Robert A ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

LDL receptor promoter; Oxidation; Reduction; Reductive alkylation; Sterol

Indexed keywords

4ALPHA (2 PROPENYL) 5ALPHA CHOLEST 24 EN 3ALPHA OL; 4ALPHA ALLYL 5ALPHA CHOLESTAN 3ALPHA OL; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHO CELL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DRUG MECHANISM; METABOLIC INHIBITION; NONHUMAN; PROMOTER REGION; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION REGULATION;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CHO CELLS; CHOLESTANOLS; CHOLESTEROL; CRICETINAE; LUCIFERASES; MAGNETIC RESONANCE SPECTROSCOPY; PROMOTER REGIONS (GENETICS); RECEPTORS, LDL; TRANSCRIPTION, GENETIC;

EID: 0033056011     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(98)00083-X     Document Type: Article

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