Alternative vaccination schedules (0, 1, and 6 months versus 0, 1, and 12 months) for a recombinant OspA Lyme disease vaccine

Clinical Infectious Diseases

Volumn 28, Issue 6, 1999, Pages 1260-1264

  Van Hoecke, C ^a,b   Lebacq, E ^a,b   Beran, J ^a,b   Parenti, D ^a,b  

^a GLAXOSMITHKLINE BIOLOGICALS   (Belgium)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL VACCINE; MEMBRANE PROTEIN; RECOMBINANT VACCINE;

ADOLESCENT; ADULT; ANTIBODY TITER; ARTICLE; BIOEQUIVALENCE; DRUG SAFETY; DRUG TOLERABILITY; HEADACHE; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; INJECTION PAIN; INTRAMUSCULAR DRUG ADMINISTRATION; LYME DISEASE; MALAISE; NORMAL HUMAN; PRIORITY JOURNAL; VACCINATION;

EID: 0033055807     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/514779     Document Type: Article

References (6)

1. 1. Centers for Disease Control and Prevention. Lyme disease United States, 1996. MMWR Morb Mortal Wkly Rep 1997; 46:531.
2. 2. Steere AC, Sikand VK, Meurice F, et al. Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer surface lipoprotein A with adjuvant. N Engl J Med 1998: 339:209-15.
3. 3. Parenti DL, Gillet M, Sennewald E, et al. Correlate of protection for Lyme disease (LD) using LYMErix, recombinant, adjuvanted Borrelia burgdorferi outer surface lipoprotein A (L-OspA) vaccine [abstract no 704]. Clin Infect Dis 1998; 27:1053.
4. 4. Van Hoecke C, Comberbach M, De Grave D, et al. Evaluation of the safety, reactogenicity and immunogenicity of three recombinant outer surface protein (OspA) Lyme vaccines in healthy adults. Vaccine 1996; 14:1620-6.
5. 5. Karpinski KF, Hayward S, Tryphonas H. Statistical considerations in the quantitation of serum immunoglobulin levels using the enzyme linked immunosorbent assay (ELISA). J Immunol Methods 1987; 103:189-94.
6. 6. Anderson S, Hauck WW. A new procedure for testing equivalence in comparative bioavailability and other clinical trials. Communication in Statistics Theory and Methods 1983; 12:2663-92.