Matrilysin as a target for chemotherapy for colon cancer: Use of antisense oligonucleotides as antimetastatic agents

Cancer Chemotherapy and Pharmacology, Supplement

Volumn 43, Issue , 1999, Pages

  Miyazaki, Kaoru ^a   Koshikawa, Naohiko ^a   Hasegawa, Satoshi ^a,b   Momiyama, Nobuyoshi ^b   Nagashima, Yoji ^b   Moriyama, Kayano ^a   Ichikawa, Yasushi ^b   Ishikawa, Takashi ^b   Mitsuhashi, Masato ^c   Shimada, Hiroshi ^b  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

^c Hitachi Chemical Research Center   (United States)

Author keywords

Antisense oligonucleotide MMP; Colon cancer; Matrilysin; Metastasis

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; MATRILYSIN;

CANCER INHIBITION; CANCER INVASION; COLON CANCER; CONFERENCE PAPER; DRUG TARGETING; LIVER METASTASIS; METASTASIS INHIBITION; PRIORITY JOURNAL; TREATMENT PLANNING;

EID: 0033055605     PISSN: 09439404     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800051098     Document Type: Conference Paper

References (33)

1. Agrawal S, Temsamani J, Tang YJ (1991) Pharmacokinetics, biodistribution, and stability of oligonucleotide phosphorothioate in mice. Proc Natl Acad Sci USA 88: 7975
2. Alvarez OA, Carmichael DF, DeClerck YA (1990) Inhibition of collagenolytic activity and metastasis of tumor cells by a recombinant human tissue inhibitor of metalloproteinases. J Natl Cancer Inst 82: 589
3. Basset P, Bellocq JP, Chambon P (1990) A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. Nature 348: 699
4. Conway JG, Trexler SJ, Wakefield JA, Marron BE, Emerson DL, Bickett DM, Deaton DN, Garrison D, Elder M, McElroy A, Willmott N, Dockerty AJP, McGeehan GM (1996) Effect of matrix metalloproteinase inhibitors on tumor growth and spontaneous metastasis. Clin Exp Metastasis 14: 115
5. Hasegawa S, Koshikawa N, Momiyama N, Moriyama K, Ichikawa Y, Ishikawa T, Mitsuhashi M, Shimada H, Miyazaki K (1998) Inhibition of liver metastasis of human colon cancer cells by matrilysin-specific antisense oligonucleotide in nude mouse model. Int J Cancer 76: 812
6. Hirahara F, Miyagi Y, Miyagi E, Yasumitsu H, Koshikawa N, Nagashima Y, Kitamura H, Minaguchi H, Umeda M, Miyazaki K (1995) Trypsinogen expression in human ovarian carcinomas. Int J Cancer 63: 176
7. Ishikawa T, Ichikawa Y, Mitsuhashi M, Momiyama N, Chishima T, Tanaka K, Yamaoka H, Miyazaki K, Nagashima Y, Akitaya T, Shimada H (1996) Matrilysin is associated with progression of colon tumor. Cancer Lett 106: 5
8. Koshikawa N, Yasumitsu H, Umeda M, Miyazaki K (1992) Multiple secretion of matrix serine proteinases by human gastric carcinoma cell lines. Cancer Res 52: 5046
9. Koshikawa N, Hasegawa S, Nagashima Y, Mitsuhashi K, Tsubota Y, Miyata S, Miyagi Y, Yasumitsu H, Miyazaki K (1998) Expression of trypsin by epithelial cells of various tissues, leukocytes and neurons in human and mouse. Am J Pathol 153: 937
10. Leonetti DA, Lozupone F, Valentini A, Geiser T, Zon G, Calabrettera B, Citro GC, Zupi G (1996) Antitumor effect of c-myc antisense phosphorothioate oligonucleotides on human melanoma cells in vitro and in mice. J Natl Cancer Inst 88: 419
11. McDonnell S, Navre M, Coffey RJ Jr, Matrisian LM (1991) Expression and localization of the matrix metalloproteinase Pump-1 (MMP-7) in human gastric and colon carcinomas. Mol Carcinog 4: 527
12. Miyazaki K, Hattori Y, Umenishi F, Yasumitsu H, Umeda M (1990) Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (PUMP-1), secreted from human rectal carcinoma cell line. Cancer Res 50: 7758
13. Momiyama N, Koshikawa N, Ishikawa T, Ichikawa Y, Hasegawa S, Nagashima Y, Mitsuhashi M, Miyazaki K, Shimada H (1998) Inhibitory effect of matrilysin antisense oligonucleotides on human colon cancer cell invasion in vitro. Mol Carcinog 22: 57
14. Muller D, Quantin B, Gesnel MC, Millon-Collard R, Abecassis J, Breathnach R (1990) The collagenase gene family in humans consists of at least four members. Biochem J 253: 187
15. Nagashima Y, Hasegawa S., Koshikawa N, Taki A, Ichikawa Y, Kitamura H, Misugi K, Kihira Y, Matsuo Y, Yasumitsu H, Miyazaki K (1997) Expression of matrilysin in vascular endothelial cell adjacent to matrilysin-producing tumor. Int J Cancer 72: 1
16. Nakano A, Tani E, Miyazaki K, Yamamoto Y, Furuya J (1995) Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas. J Nerosurg 83: 298
17. Narayanan R, Akhtar S (1996) Antisense therapy. Curr Opin Oncol 8: 509
18. Newell K, Witty J, Rodgers WH, Matrisian LM (1994) Expression and localization of the matrix metalloproteinases during colon carcinogenesis. Mol Carcinog 10: 199
19. Pajouh MS, Nagle RB, Breathnach R, Brawer MK, Bowden GT (1991) Expression of metalloproteinase genes in human prostate cancer. J Cancer Res Clin Oncol 117: 144
20. Pyke C, Palfkiaer M, Dano K (1993) Messenger RNA for two type IV collagenases is located in stromal cells in human colon cancer. Am J Pathol 142: 359
21. Saijo Y, Perlaky L, Wang H, Busch H (1994) Pharmacokinetics, tissue distribution, and stability of antisense oligonucleotide phosphorothioate ISIS3466 in mice. Oncol Res 6: 243
22. Schultz RM, Silberman S, Persky B, Bajowski AS, Carmichael DF (1988) Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells. Cancer Res 48: 5539
23. Stein CA, Cheng YC (1993) Antisense oligonucleotides as therapeutic reagents - is the bullet really magical? Science 261: 1004
24. Stetler-Stevenson WG, Azanavoorian S, Liotta LA (1993) Tumor cell interactions with the extracellular matrix during invasion and metastasis. Ann Rev Cell Biol 9: 541
25. Takeuchi N, Ichikawa Y, Ishikawa T, Momiyama N, Hasegawa S, Nagashima Y, Miyazaki K, Koshikawa N, Mitsuhashi M, Shimada H (1997) Matrilysin gene expression in sporadic and familial colorectal adenomas. Mol Carcinog 19: 225
26. Wang X, Fu X, Brown DP, Crimmin JM, Hoffman MR (1994) Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Res 54: 4726
27. Watson SA, Morris TM, Robinson G, Crimmin MJ, Brown PD, Hardcastle JD (1995) Inhibition of organ invasion by the matrix metalloproteinase inhibitor batimastat (BB-94) in two human colon carcinoma models. Cancer Res 55: 3629
28. Wilson CL, Matrisian LM (1996) Matrilysin: an epithelial matrix metalloproteinase with potentially novel functions. Int J Biochem Cell Biol 28: 123
29. Wilson CL, Heppner KJ, Labosky PA, Hogan BLM, Matrisian LM (1997) Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. Proc Natl Acad Sci USA 94: 1402
30. Witty JP, McDonnell S, Newell JK, Cannon P, Navre M, Tressler JR, Matrisian LM (1994) Modulation of matrilysin levels in colon carcinoma cell lines affects tumorigenicity in vivo. Cancer Res 54: 4805
31. Woessner JF Jr, Talpin C (1988) Purification and properties of a small latent matrix metalloproteinase of the rat uterus. J Biol Chem 263: 16918
32. Yamamoto H, Itoh F, Hinoda Y, Imai K (1995) Suppression of matrilysin inhibits colon cancer cell invasion in vitro. Int J Cancer 61: 218
33. Yoshimoto M, Itoh F, Yamamoto H, Hinoda Y, Imai K, Yachi A (1993) Expression of MMP-7 (pump-1) mRNA in human colorectal cancers. Int J Cancer 54: 614