Pharmacology of G-1-64, a new nondepolarizing neuromuscular blocking agent with rapid onset and short duration of action

Acta Anaesthesiologica Scandinavica

Volumn 43, Issue 6, 1999, Pages 651-657

  Gyermek, Laszlo ^a   Lee, C ^a   Nguyen, N ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

Bis quaternary ammonium salt of bistropinyl diester; Neuromuscular block; Neuromuscular pharmacology; Onset and duration of neuromuscular block

Indexed keywords

ATRACURIUM; BISTROPINYL DIESTER DERIVATIVE; G 164; MIVACURIUM; NEUROMUSCULAR BLOCKING AGENT; ROCURONIUM; SUXAMETHONIUM; UNCLASSIFIED DRUG;

ARTERIAL PRESSURE; ARTICLE; BRADYCARDIA; CAT; DRUG ACTIVITY; FERRET; HEART RATE; MONKEY; NEUROMUSCULAR BLOCKING; NICTITATING MEMBRANE; PRIORITY JOURNAL; SUPERIOR CERVICAL GANGLION; SWINE; SYMPATHETIC BLOCKING; VAGUS NERVE;

ANDROSTANOLS; ANIMALS; ATRACURIUM; CATS; ELECTROMYOGRAPHY; FERRETS; GLUTARATES; HEART RATE; HINDLIMB; MACACA; NEUROMUSCULAR BLOCKADE; NEUROMUSCULAR NONDEPOLARIZING AGENTS; RABBITS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; SYNAPTIC TRANSMISSION; TIME FACTORS; TROPANES;

EID: 0033055310     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-6576.1999.430610.x     Document Type: Article

References (22)

1. Savarese JJ, Kitz RJ. Does clinical anesthesia need new neuromuscular blocking agents? Anesthesiology 1975; 42: 236-239.
2. Fodor G, Nador K. The stereochemistry of tropane alkaloids 1. J Chem Soc 1953: 721.
3. Fodor G. The tropane alkaloids. In: Pelletier SW, ed. Chemistry of the Alkaloids. N.Y., USA: Van Nostrand Reinhold, 1970: 431-467.
4. Gyermek L, Nador K. Pharmacology of tropane compounds in relation to their steric structure. J Pharm Pharmacol 1957; 9: 209-229.
5. Gyermek L. Ganglionic stimulant and blocking agents. In: Burger A, ed. Drugs Affecting the Peripheral Nervous System. N.Y., USA: M. Dekker, 1967: 149-232.
6. Engelhardt A, Wick H. Beziechungen zwischen konstitution und wirkung bei tropeinen und ihren quartären derivaten unter besonderer berucksichtigung des N,N′-octylatropinium bromide. Arzneim Forsch 1957; 7: 217-222.
7. Gyermek L, Nador K. Pharmacology of p-biphenylmethyl dl-tropyltropinium bromide. Arch Int Pharmacodyn 1957; 113: 1-14.
8. Parkes GE, Brodgen RN, Heel RC, Speight TM, Avery GS. Ipratropium bromide: A review of its pharmacological properties and therapeutic efficacy in asthma and chronic bronchitis. Drugs 1980; 20: 237-266.
9. Bauer R. Zur Pharmakologie des bronchospasmolytikums oxytropium bromide. Arzneim Forsch 1985; 35: 435-440.
10. Robertson JD, Gillis J, Spencer. The use of a homatropine derivative to produce controlled hypotension. Br J Anaesth 1957; 29: 342-357.
11. Issekutz B. Bie wirkung einiger neuen quaternären ammonium basen auf die neuromuskulären und ganglionären synapsen. Arch Exp Path Pharmakol 1952; 215: 283-2981.
12. Haining CG, Johnston RG. Neuromuscular blocking properties of some bistropinium esters. Br J Pharmacol 1962; 18: 275-286.
13. Gyermek L, Nador K. Studies on cholinergic blocking substances III. Neuromuscular blocking tropeines. Acta Physiol Acad Sci Hung 1953; 4: 159-174.
14. Cavallito C. Curare and Curare-Like Agents. Bovet D, ed. Amsterdam: Elsevier, 1959: 288.
15. Haining CG, Johnston RG, Smith JM. The neuromuscular blocking properties of a series of bisquaternary tropeines. B J Pharmacol 1960; 15: 71-81.
16. Kimura KK, Unnal KR, Pfeiffer CC. Diatropine derivatives as proof that d-tubocurarine is a blocking moiety containing twin atropine-acetylcholine prosthetic groups. J Pharmacol Exp Ther 1949; 95: 149-154.
17. Kimura KK, Unna KR. Curare-like action of decamethylene bis-10 (atropinium iodide). J Pharmacol Exp Ther 1950; 98: 286-292.
18. Gyermek L, Nador K. Studies on cholinergic blocking substances II. Correlations of the antimuscarine, antinicotine and curare-like effects of mono and bisquaternary tropeines. Acta Physiol Acad Sci Hung 1952; 3: 183-193.
19. Lee C, deSilva AJC, Katz RL. Multipeaking of the compound electromyographic response to single nerve stimulus: Its occurrence and prevention in an experimental model. Br J Anaesth 1978; 50: 459-462.
20. Muir AW, Houston J, Marshall RG, Bowman WC, Marshall JG. A comparison of the neuromuscular blocking and autonomic effects of two new short-acting muscle relaxants with those of succinylcholine in the anesthetized cat and pig. Anesthesiology 1989; 70: 533-540.
21. Booij LHDJ, Marshall JG, Gal JF et al. Pharmacology of four steroidal muscle relaxants. Abstract No. A0533, World Congress of Anesthesiology, Washington, D.C., 1988.
22. Gyermek L, Wymore J. Old and new nondepolarizing muscle relaxants: A reassessment on subhuman primates. Arch Int Pharmacodyn Ther 1982; 257: 114-129.