Parallel synthesis of polyethylene glycol supported biaryl benzimidazoles and imidazopyridines

Synlett

Volumn , Issue 3, 1999, Pages 307-310

  Blettner, Carsten G ^a,b   König, Wilfried A ^a   Rühter, Gerd ^b   Stenzel, Wolfgang ^b   Schotten, Theo ^b  

^a UNIVERSITY OF HAMBURG   (Germany)

^b BEIERSDORF AG   (Germany)

Author keywords

Benzimidazole; Liquid phase synthesis; Polyethylene glycol; Suzuki reaction

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; IMIDAZOPYRIDINE DERIVATIVE; MACROGOL;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; ORGANIC CHEMISTRY; SYNTHESIS;

EID: 0033054018     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1999-2598     Document Type: Article

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24. 3): 10.08(1H, s); 8.33 (1H, s); 8.11 (1H, d, J = 7.7 Hz); 7.98 (2H, d, J = 8.10 Hz); 7.83 (1H, d, J = 7.55 Hz); 7.79 (2H, d, J = 8.05 Hz); 7.57 (1H, t, J = 7.68 Hz); 4.52 (2H, t, J = 4.75 Hz); 3.78 - 3.50 (m, PEG).; m = 8.47g, 94%.
25. 1H-NMR (500 MHz, MeOH): 8.92 (1H, s); 8.36 (1H, s); 8.34-8.30 (3H, m); 8.08 (1H, d, J = 7.70 Hz); 8.01 (1H, d, J = 7.65 Hz); 7.93 (2H, d, J = 8.15 Hz); 7.66 (1H, d, J = 5.65 Hz); 7.65 (1H, t, J = 7.75 Hz); 4.52 (2H, t, J = 4.50 Hz); 3.76-3.49 (PEG, m); m = 0.90 g, 87%.
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29. 2, 329.1164; found, 329.1154; m = 25 mg; 41%.