The novel carboxamide derivative IS-741 reduces neutrophil chemoattractant production by bronchoalveolar macrophages in rats with cerulein-induced pancreatitis complicated by sepsis

Digestion

Volumn 60, Issue SUPPL. 1, 1999, Pages 52-56

  Yamaguchi, Yasuo ^a   Okabe, Kazutoshi ^a   Liang, Jian ^a   Matsumura, Fujio ^a   Akizuki, Eiji ^a   Matsuda, Teishi ^a   Ohshiro, Hajime ^a   Nakano, Shogo ^a   Ishihara, Kohjiroh ^a   Ogawa, Michio ^a,b  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^b Department of Surgery II ^*  (Japan)

Author keywords

Bronchoalveolar macrophage; Cytokine induced neutrophil chemoattractant; Pancreatitis; Septic complication

Indexed keywords

AMIDE; CD11B ANTIGEN; CERULETIDE; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; LIPOPOLYSACCHARIDE; N (2 ETHYLSULFONYLAMINO 5 TRIFLUOROMETHYL 3 PYRIDYL)CYCLOHEXANECARBOXAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL INFILTRATION; CONFERENCE PAPER; CONTROLLED STUDY; LUNG ALVEOLUS MACROPHAGE; LUNG HEMORRHAGE; MALE; MONONUCLEAR CELL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PANCREATITIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SEPSIS;

EID: 0033053803     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000051454     Document Type: Conference Paper

References (15)

1. Guo L, Yamaguchi Y, Ikei S, Sugita H, Ogawa M: Neutrophil elastase inhibitor (ONO-5046) prevents lung hemorrhage induced by lipopolysaccharide in a rat model of cerulein pancreatitis. Dig Dis Sci 1995;40:2177-2183.
2. Watanabe K, Suematsu M, Iida M, Takaishi K, Iizuka Y, Suzuki H, Suzuki M, Tsuchiya M, Tsurufuji S: Effect of rat CINC/gro, a member of interleukin-8 family, on leukocytes in micro-circulation of the rat mesentery. Exp Mol Pathol 1992;56:60-69.
3. Sugita H, Yamaguchi Y, Ikei S, Yamada S, Ogawa M: Enhanced expression of cytokine-induced neutrophil chemoattractant (CINC) by bronchoalveolar macrophages in cerulein-induced pancreatitis rats. Dig Dis Sci 1997;42: 154-160.
4. Kimura H, Yotsuya S, Yuki S, Sugi H, Shigehara I, Haga T: Synthesis and antipancreatitis activities of novel N-(2-sulfonylamino-5-trifluoromethyl-3-pyridyl) carboxamide derivatives as phospholipase A2 inhibitors. Chem Pharm Bull 1995;43:1696-1700.
5. Nakagawa H, Ikesue A, Kato H, Debuchi H, Watanabe K, Turufuji S, Naganawa M, Mitamura M: Changes in the levels of rat interleukin 8/CINC and gelatinase in the exudate of carrageenan-induced inflammation in rats. J Pharmacobio-Dynam 1992;15:461-466.
6. Yam LT, Li CY, Crosby WH: Cytochemical identification of monocytes and granulocytes. Am J Clin Pathol 1971;55:283-290.
7. Sibille Y, Reynolds HY: Macrophages and polymorphonuclear neutrophils in lung defense and injury. Am Rev Respir Dis 1990;141:471-501.
8. Nolte D, Hecht R, Schmid P, Botzlar A, Menger MD, Neumueller C, Sinowatz F, Vestweber D, Messmer K: Role of Mac-1 and ICAM-1 in ischemia-reperfusion injury in a microcirculation model of BALB/C mice. Am J Physiol 1994;267:H1320-H1328.
9. Palermo MS, Alves Rosa F, Fernandez Alonso G, Isturiz MA: Fc gamma receptor-dependent clearance is enhanced following lipopolysaccharide in vivo treatment. Immunology 1997; 92:536-543.
10. Crockett-Torabi E, Sulenbarger B, Smith CW, Fantone JC: Activation of human neutrophils through L-selectin and Mac-1 molecules. J Immunol 1995;154:2291-2302.
11. Shappell SB, Toman C, Anderson DC, Taylor AA, Entman ML, Smith CW: Mac-1 (CD11b/ CD18) mediates adherence-dependent hydrogen peroxide production by human and canine neutrophils. J Immunol 1990;144:2702-2711.
12. Entman ML, Schmalstieg FC, Smith CW: Neutrophil adherence to isolated adult canine myocytes: Evidence for a CD18-dependent mechanism. J Clin Invest 1990;85:1497-1506.
13. Jaeschke H, Farhood A, Bautista AP, Spolarics Z, Spitzer JJ, Smith CW: Functional inactivation of neutrophils with a Mac-1 (CD11b/ CD18) monoclonal antibody protects against ischemia/reperfusion injury in rat liver. Hepatology 1993;17:915-923.
14. Frevert CW, Huang S, Danaee H, Paulauskis JD, Kobzik L: Functional characterization of the rat chemokine KC and its importance in neutrophil recruitment in a rat model of pulmonary inflammation. J Immunol 1995;154: 335-344.
15. Bozic CR, Kolakowski LF Jr, Gerard NP, Garcia-Rodriguez C, von Uexkull-Guldenband C, Conklyn MJ, Breslow R, Showell HJ, Gerard C: Expression and biologic characterization of the murine chemokine KC. J Immunol 1995; 154:6048-6057.