High-performance liquid chromatographic determination of trimebutine and its major metabolite, N-monodesmethyl trimebutine, in rat and human plasma

Journal of Chromatography B: Biomedical Sciences and Applications

Volumn 723, Issue 1-2, 1999, Pages 239-246

  Joo, Eun Hee ^a   Chang, Woo Ik ^a   Oh, Injoon ^a   Shin, Sang Chul ^a   Na, Han Kwang ^b   Lee, Yong Bok ^a  

^a Chonnam National University   (South Korea)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

N Monodesmethyltrimebutine; Trimebutine

Indexed keywords

DRUG METABOLITE; TRIMEBUTINE MALEATE; VERAPAMIL;

ADULT; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; EXTRACTION; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; VOLUNTEER;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GASTROINTESTINAL AGENTS; HUMANS; MALE; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROPHOTOMETRY, ULTRAVIOLET; TRIMEBUTINE;

EID: 0033053291     PISSN: 13872273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(98)00516-7     Document Type: Article

References (21)

1. Moshal M.G., Herron M. J. Int. Med. Res. 7:1979;231.
2. Lüttecke K. Curr. Med. Res. Opin. 6:1980;437.
3. Frexinos J., Fioramonti J., Bueno L. Eur. J. Clin. Pharmacol. 28:1985;181.
4. Poitras P., Honde C., Havrankova J., Lahaie R.G., Trudel L., Goyer R., Junien J.L., Pascaud X. Am. J. Physiol. 251:1986;G349.
5. Boige N., Cargill G., Mashako L., Cezard J.P., Navarro J. J. Ped. Gastroenterol. Nutr. 6:1987;548.
6. Miura Y., Takeyama S., Yoshikawa M., Endo H., Furuuchi S., Harigaya S. Yakugaku Zasshi. 108:1988;989.
7. Miura Y., Chishima S., Takeyama S. Drug Metab. Dispos. 17:1989;455.
8. Fioramonti J., Fargeas M.J., Bueno L. J. Pharm. Pharmacol. 36:1984;618.
9. Blanquet F., Bouvier M., Gonella J. J. Pharmacol. Exp. Ther. 234:1985;708.
10. Roman F., Pascaud X., Taylor J.E., Junien J.L. J. Pharm. Pharmacol. 39:1987;404.
11. Chaussade S., Grandjouan S., Couturier D., Thierman-Duffaud D., Henry J.F. Eur. J. Clin. Pharmacol. 32:1987;615.
12. Daniel E.E., Kostolanska F., Allescher H.D., Ahmad S., Fox J.E.T. J. Pharmacol. Exp. Ther. 245:1988;1002.
13. Kaneto H., Takahashi M., Watanabe J. J. Pharmacobio-Dyn. 13:1990;448.
14. Allescher H.D., Ahmad S., Classen M., Daniel E.E. J. Pharmacol. Exp. Ther. 257:1991;836.
15. Taniyama K., Sano I., Nakayama S., Matsuyama S., Takeda K., Yoshihama C., Tanaka C. Gastroenterology. 101:1991;1579.
16. Astier A., Deutsch A.M. J. Chromatogr. 224:1981;149.
17. C.M. Metzler, D.L. Weiner, PCNONLIN, Ver. 4.1., SCI Software, Lexington, 1992.
18. Gibaldi M., Perrier D. Pharmacokinetics. 1982;Marcel Dekker, New York.
19. Greving J.E., Bouman H., Jonkman J.H.G., Westenberg H.G.M., de Zeeuw R.A. J. Chromatogr. 186:1979;683.
20. Wehrli A., Hildenbrand J.C., Keller H.P., Stampfli R., Frei R.W. J. Chromatogr. 149:1978;199.
21. Little C.J., Dale A.D., Whatley J.A., Wickings J.A. J. Chromatogr. 169:1979;381.