GABA(B) receptor-mediated stimulation of adenylyl cyclase activity in membranes of rat olfactory bulb

British Journal of Pharmacology

Volumn 126, Issue 3, 1999, Pages 657-664

  Olianas, Maria C ^a   Onali, Pierluigi ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Adenylyl cyclase; G protein subunits; GABA(B) receptors; Rat olfactory bulb

Indexed keywords

2 HYDROXYSACLOFEN; 3 AMINOPROPANEPHOSPHINIC ACID; 3 AMINOPROPYL(DIETHOXYMETHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; ADENYLATE CYCLASE; BACLOFEN; BENZYL[3 [[1 (3,4 DICHLOROPHENYL)ETHYL]AMINO] 2 HYDROXYPROPYL]PHOSPHINIC ACID; FORSKOLIN; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; PERTUSSIS TOXIN; PHACLOFEN; TRANSDUCIN;

ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; ENZYME ACTIVITY; GRANULE CELL; MALE; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; RAT;

ADENYLATE CYCLASE; ADENYLATE CYCLASE TOXIN; ANIMALS; BACLOFEN; CALCIUM; CALMODULIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; FORSKOLIN; GABA AGONISTS; GABA ANTAGONISTS; INDOMETHACIN; INJECTIONS, INTRAVENTRICULAR; MALE; MEMBRANES; NEUROPEPTIDES; NEUROPROTECTIVE AGENTS; OLFACTORY BULB; ORGANOPHOSPHORUS COMPOUNDS; PERTUSSIS TOXIN; PHOSPHINIC ACIDS; PHOSPHOLIPASES A; PHOSPHOLIPIDS; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; PROPANOLAMINES; PROPYLAMINES; QUINACRINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-B; TRANSDUCIN; VIRULENCE FACTORS, BORDETELLA;

EID: 0033052398     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702349     Document Type: Article

References (40)

1. ARUNLAKSHANA, O. & SCHILD, H.O. (1959). Some quantitative uses of drug antagonists. Br. J. Pharmacol. Chemother., 14, 48- 57.
2. B receptor antagonists: from synthesis to therapeutic application. Trends Pharmacol. Sci., 14, 391-393.
3. B receptor pharmacology. Annu. Rev. Pharmacol. Toxicol., 33, 109-147.
4. B receptor site distribution in the rat central nervous system. Neuroscience, 20, 365-383.
5. BRADFORD, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
6. B binding sites in rat central nervous system: a quantitative autoradiographic study. Neuroscience, 34, 341-357.
7. B receptors associated with cAMP production in rat brain. Brain Res., 720, 220-224.
8. 2 and C in the α-adrenergic and γ-aminobutyric acid receptor modulation of cyclic AMP accumulation in rat brain slices. J. Neurochem., 47, 800-810.
9. B receptors and transmitter-stimulated cAMP accumulation in rat brain. Neuropharmacology, 23, 821-822.
10. ENNA, S.J. & KARBON, E.W. (1987). Receptor regulation: evidence for a relationship between phospholipid metabolism and neurotransmitter receptor-mediated cAMP formation in brain. Trends Pharmacol. Sci., 8, 21-24.
11. 7 subunits. Nature, 356, 159-161.
12. 2+/calmodulin-insensitive adenylyl cyclase from rat brain. Proc. Natl. Acad. Sci. USA, 88, 10173-10177.
13. GLATT, C.E. & SNYDER, S.H. (1993). Cloning and expression of an adenylyl cyclase localized to the corpus striatum. Nature, 361, 536-538.
14. B receptors. Neuropharmacology, 23, 829-830.
15. B receptor agonist in the guinea-pig ileum and rat anococcygeus muscle. Br. J. Pharmacol., 97, 1292-1296.
16. KARBON, E.W. & ENNA, S.J. (1985). Characterization of the relationship between γ-aminobutyric acid B agonists and transmitter-coupled cyclic nucleotide-generating systems in rat brain. Mol. Pharmacol., 27, 53-59.
17. B receptors uncovers similarity to metabotropic glutamate receptors. Nature, 386, 239-246.
18. B receptors in rat brain slices. Neuropharmacology, 35, 703-712.
19. B receptor agonists and antagonists. Clin. Neuropharm., 18, 285-305.
20. 12. FEBS Lett., 271, 231-235.
21. s-linked neurotransmitter receptors to stimulate adenylyl cyclase activity of rat olfactory bulb. J. Neurochem., 61, 2183-2190.
22. B receptors to adenylyl cyclase in rat olfactory bulb. Proc. Soc. Neurosci., 22, 1293.
23. OLIANAS, M.C. & ONALI, P. (1996b). Characterization of the G protein involved in the muscarinic stimulation of adenylyl cyclase of rat olfactory bulb. Mol. Pharmacol., 49, 22-29.
24. γ subunits in muscarinic receptor-induced stimulation and inhibition of adenylyl cyclase activity in rat olfactory bulb. J. Neurochem., 70, 2620-2627.
25. B agonist in rat brain tissue. Br. J. Pharmacol., 96, 141P.
26. B receptor biochemistry. Br. J. Pharmacol., 98, 833-840.
27. SALOMON, Y., LONDOS, C. & RODBELL, M. (1974). A highly sensitive adenylate cyclase assay. Anal. Biochem, 58, 541-548.
28. SCHAAD, N.C., SCHORDERET, M. & MAGISTRETTI, P.J. (1989). Accumulation of cyclic AMP elicited by vasoactive intestinal peptide is potentiated by noradrenaline, histamine, adenosine, baciofen, phorbol esters, and ouabain in mouse cerebral cortical slices: studies on the role of arachidonic acid metabolites and protein kinase C. J. Neurochem., 53, 1941-1951.
29. B receptors. Brain Res. Bull., 21, 439-443.
30. B receptor activation modifies agonist binding to β-adrenergic receptors in rat brain cerebral cortex. J. Neurochem., 53, 989-991.
31. SUNAHARA, R.K., DESSAUER, C.W. & GILMAN, A.G. (1996). Complexity and diversity of mammalian adenylyl cyclases. Annu. Rev. Pharmacol. Toxicol., 36, 461-480.
32. TALLARIDA, R.J. & MURRAY, R.B. (1987). Manual of Pharmacologic Calculations with Computer Programs. Springer-Verlag, New York.
33. TANG, W.-J. & GILMAN, A.G. (1992). Adenylyl Cyclases. Cell, 70, 869-872.
34. γ subunits. Biochem. Biophys. Res. Comm., 241, 476-480.
35. B receptor-mediated enhancement of vasoactive intestinal peptide-stimulated cyclic AMP production in slices of rat cerebral cortex. J. Neurochem., 46, 1756-1762.
36. B receptors in physiology and pathology. Neuropsychopharmacology, 6, 201-214.
37. WOJCIK, W.J. & NEFF, N.H. (1984). γ-Aminobutyric acid B receptors are negatively coupled to adenylate cyclase in brain, and in the cerebellum these receptors may be associated with granule cells. Mol. Pharmacol., 25, 24-28.
38. B receptors. J. Neurochem., 53, 753-758.
39. XIA, Z., REFSDAL, C.D., MERCHANT, K.M., DORSA, D.M. & STORM, D.R. (1991). Distribution of mRNA for the calmodulin-sensitive adenylyl cyclase in rat brain: expression in areas associated with learning and memory. Neuron, 6, 431-443.
40. B receptor-mediated inhibition of adenylate cyclase in cultured cerebellar granule cells: blockade by islet activating protein. J. Pharmacol. Exp. Ther., 239, 568-573.