Structural consequences of anesthetic and nonimmobilizer interaction with gramicidin A channels

Biophysical Journal

Volumn 76, Issue 5, 1999, Pages 2346-2350

  Tang, Pei ^a,b,c   Simplaceanu, Virgil ^a   Xu, Yan ^a,b  

^a CARNEGIE MELLON UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DICHLOROHEXAFLUOROCYCLOBUTANE; DODECYL SULFATE SODIUM; GRAMICIDIN; INDOLE DERIVATIVE; INHALATION ANESTHETIC AGENT; ION CHANNEL; TRYPTOPHAN;

ARTICLE; HYDROPHOBICITY; MEMBRANE STRUCTURE; MICELLE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN DOMAIN; PROTEIN LIPID INTERACTION; PROTEIN SECONDARY STRUCTURE; SYNAPTIC MEMBRANE;

EID: 0033051990     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(99)77391-1     Document Type: Article

References (24)

1. 1H-NMR study of gramicidin A transmembrane ion channel. Head-to-head right-handed, single-stranded helices. FEBS Lett. 186:168-174.
2. Cross, T. A. 1994. Structural biology of peptides and proteins in synthetic membrane environments by soild-state NMR spectroscopy. Annu. Rep. NMR Spectrosc. 29:123-167.
3. Cross, T. A. 1997. Solid-state nuclear magnetic resonance characterization of gramicidin channel structure. Methods Enzymol. 289:672-696.
4. Eckenhoff, R. G., and J. S. Johansson. 1997. Molecular interactions between inhaled anesthetics and proteins. Pharmacol. Rev. 49:343-367.
5. Forman, S. A., K. W. Miller, and G. Yellen. 1995. A discrete site for general anesthetics on a postsynaptic receptor. Mol. Pharmacol. 48: 574-581.
6. Franks, N. P., and W. R. Lieb. 1994. Molecular and cellular mechanisms of general anaesthesia. Nature. 367:607-614.
7. Franks, N. P., and W. R. Lieb. 1997. Inhibitory synapses. Anaesthetics set their sites on ion channels. Nature. 389:334-335.
8. Hu, W., and T. A. Cross. 1995. Tryptophan hydrogen bonding and electric dipole moments: functional roles in the gramicidin channel and implications for membrane proteins. Biochemistry. 34:14147-14155.
9. Hu, W., K. C. Lee, and T. A. Cross. 1993. Tryptophans in membrane proteins: indole ring orientations and functional implications in the gramicidin channel. Biochemistry. 32:7035-7047.
10. Kendig, J. J., A. Kodde, L. M. Gibbs, P. Ionescu, and E. I. Eger. 1994. Correlates of anesthetic properties in isolated spinal cord: cyclobutanes. Eur. J. Pharmacol. 264:427-436.
11. Ketchem, R., B. Roux, and T. Cross. 1997. High-resolution polypeptide structure in a lamellar phase lipid environment from solid state NMR derived orientational constraints. Structure. 5:1655-1669.
12. Killian, J. A., T. P. Trouard, D. V. Greathouse, V. Chupin, and G. Lindblom. 1994. A general method for the preparation of mixed micelles of hydrophobic peptides and sodium dodecyl sulphate. FEBS Lett. 348:161-165.
13. Lomize, A. L., V. Orekhov, and A. S. Arsen'ev. 1992. Utochnenie prostranstvennoi struktury ionnogo kanala gramitsidina A [Refinement of the spatial structure of the gramicidin A ion channel]. Bioorg. Khim. 18: 182-200.
14. Mihic, S. J., Q. Ye, M. J. Wick, V. V. Koltchine, M. D. Krasowski, S. E. Finn, M. P. Mascia, C. F. Valenzuela, K. K. Hanson, E. P. Greenblatt, R. A. Harris, and N. L. Harrison. 1997. Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. Nature. 389: 385-389.
15. Mobashery, N., C. Nielsen, and O. S. Andersen. 1997. The conformational preference of gramicidin channels is a function of lipid bilayer thickness. FEBS Lett. 412:15-20.
16. North, C., and D. S. Cafiso. 1997. Contrasting membrane localization and behavior of halogenated cyclobutanes that follow or violate the Meyer-Overton hypothesis of general anesthetic potency. Biophys. J. 72: 1754-1761.
17. 19F NMR study. Biophys. J. 72:1676-1682.
18. Trudeau, G., K. C. Cole, R. Massuda, and C. Sandorfy. 1978. Anesthesia and hydrogen bonding: a semi-quantitative infrared study at room temperature. Can. J. Chem. 56:1681-1686.
19. Urry, D. W., and C. Sandorfy. 1991. Chemical modulation of transmembrane protein structure and function. In Drug and Anesthetic Effects on Membrane Structure and Function. R. C. Aloia, C. C. Curtain, and L. M. Gordon, editors. Wiley-Liss, New York. 91-131.
20. 1H NMR chemical shifts in proteins. J. Am. Chem. Soc. 105:5948-5949.
21. 19F nuclear magnetic resonance study. Proc. Natl. Acad. Sci. USA. 76:4230-4234.
22. Woolf, T. B., and B. Roux. 1997. The binding site of sodium in the gramicidin A channel: comparison of molecular dynamics with solid-state NMR data. Biophys. J. 72:1930-1945.
23. 1H} intermolecular nuclear Overhauser effects. Biochim. Biophys. Acta. 1323:154-162.
24. Xu, Y., P. Tang, and S. Liachenko. 1998. Unifying characteristics of sites of anesthetic action revealed by combined use of anesthetics and non-anesthetics. Toxicol. Lett. 100-101:347-352.