Human endogenous retrovirus with a high genomic sequence homology with IDDMK1,222 is not specific for Type I (insulin-dependent) diabetic patients but ubiquitous

Diabetologia

Volumn 42, Issue 4, 1999, Pages 413-418

  Kim, A ^a   Jun, H S ^a   Wong, L ^a   Stephure, D ^b   Pacaud, D ^b   Trussell, R A ^b   Yoon, J W ^a,c  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c Ajou University   (South Korea)

Author keywords

A novel human endogenous retrovirus (IDDMK1,222); Autoimmune Type I diabetes; Human endogenous retrovirus (HERV) K10; Superantigen

Indexed keywords

SUPERANTIGEN;

ARTICLE; AUTOIMMUNITY; DIABETES CONTROL; GENE EXPRESSION REGULATION; GENE SEQUENCE; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RETROVIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; VIRUS GENE; VIRUS GENOME;

BASE SEQUENCE; DIABETES MELLITUS, TYPE 1; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; RETROVIRIDAE; SEQUENCE HOMOLOGY, NUCLEIC ACID; SUPERANTIGENS; VIRAL PROTEINS;

EID: 0033051690     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051173     Document Type: Article

References (10)

1. Yoon JW (1995) A new look at viruses in type 1 diabetes. Diabetes Metab Rev 11: 83-107
2. Suenaga K, Yoon JW (1988) Association of beta cell-specific expression of endogenous retrovirus with development of insulitis and diabetes in the NOD mouse. Diabetes 37: 1722-1726
3. Fujita H, Fujino H, Nonaka K, Tarui S, Tochino H (1984) Retrovirus-like particles in pancreatic beta cells of NOD mice. Biomed Res 5: 67-70
4. Fujino-Kurihara H, Fujita H, Hakura A, Nonaka K, Tarui S (1985) Morphological aspects on pancreatic islets of non-obese diabetic (NOD) mice. Virchows Arch (Cell Pathol) 49: 107-120
5. Gaskins HR, Prochazka M, Hamaguchi K, Serreze DV, Leiter EH (1992) Beta cell expression of endogenous xeno-tropic retrovirus distinguishes diabetes-susceptible NOD/ Lt from resistant NON/Lt mice. J Clin Invest 90: 2220-2227
6. Nakagawa C, Hanafusa T, Miyagawa J et al. (1992) Retrovirus gag protein p30 in the islets of nonobese diabetic mice: relevance for pathogenesis of diabetes mellitus. Diabetologia 35: 614-618
7. Serreze DV, Leiter EH, Kuff EL, Jardieu P, Ishizaka K (1988) Molecular mimicry between insulin and retroviral antigen p73. Development of cross reactive autoantibodies in sera of NOD and C57BL/KsJ-db/db mice. Diabetes 37: 351-358
8. Conrad B, Weidmann E, Trucco G et al. (1994) Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology. Nature 371: 351-355
9. Conrad B, Weissmahr RN, Böni J, Arcari R, Schüpbach J, Mach B (1997) A human endogenous retroviral superantigen as candidate autoimmune gene in type 1 diabetes. Cell 90: 303-313
10. + suppressor T-cell completely prevents spontaneous autoimmune diabetes and recurrent diabetes in syngeneic islet-transplanted NOD mice. J Autoimmunity 9: 331-339