Human red blood cell acetylcholinesterase inhibition as the appropriate and conservative surrogate endpoint for establishing chlorpyrifos reference dose

Regulatory Toxicology and Pharmacology

Volumn 29, Issue 1, 1999, Pages 15-22

  Chen, William L ^a   Sheets, Joel J ^a   Nolan, Richard J ^a   Mattsson, Joel L ^a  

^a DOW AGROSCIENCES LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; CHLORPYRIFOS; ORGANOPHOSPHATE INSECTICIDE;

ARTICLE; CHOLINESTERASE INHIBITION; COGNITIVE DEFECT; DOSE RESPONSE; DRUG EXPOSURE; DRUG SAFETY; DRUG TOLERANCE; ENVIRONMENTAL PROTECTION; ERYTHROCYTE; HUMAN; INSECT CONTROL; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

INSECTA;

EID: 0033050840     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.1998.1256     Document Type: Article

References (36)

1. Amitai G., Moorad D., Adani R., Doctor B. P. Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon. Med. Def. Biosci. Rev., Proc. 1996;85-95.
2. Atterberry T. T., Burnett W. T., Chambers J. E. Age-related differences in parathion and chlorpyrifos toxicity in male rats: Target and nontarget esterase sensitivity and cytochrome P450-mediated metabolism. Toxicol. Appl. Pharmacol. 147:1997;411-418.
3. Bushnell P. J., Kelly K. L., Ward T. R. Repeated inhibition of cholinesterase by chlorpyrifos in rats: Behavioral, neurochemical and pharmacological indices of tolerance. J. Pharmacol. Exp. Ther. 270:1994;15-25.
4. Bushnell P. J., Pope C. N., Padilla S. Behavioral and neurochemical effects of acute chlorpyrifos in rats: Tolerance to prolonged inhibition of cholinesterase. J. Pharmacol. Exp. Ther. 266:1993;1007-1017.
5. Chakraborti T. K., Farrar J. D., Pope C. N. Comparative neurochemical and neurobehavioral effects of repeated chlorpyrifos exposures in young and adult rats. Pharmacol., Biochem. Behav. 46:1993;219-224.
6. Chambers J. E., Ma T., Boone J. S., Chambers H. W. Role of detoxication pathways in acute toxicity levels of phosphorothionate insecticides in the rat. Life Sci. 54:1994;1357-1364.
7. Chanda S. M., Harp P., Liu J., Pope C. N. Comparative developmental and maternal neurotoxicity following acute gestational exposure to chlorpyrifos in rats. J. Toxicol. Environ. Health. 44:1995;189-202.
8. Costa L. G. Organophosphorus compounds. NATO ASI Ser. A. 100:1988;203-246.
9. Costa L. G., Schwab B. W., Murphy S. D. Tolerance to anticholinesterase compounds in mammals. Toxicology. 25:1982;79-97.
10. EPA, C. 1992, Chlorpyrifos (Dursban, Lorsban) Dietary Exposure Assessment, California Environmental Protection Agency, Health Assessment Section, Medical Toxicology Branch, Sacramento.
11. Hoberman, A. M. 1998, Developmental Neurotoxicity Study of Chlorpyrifos Administered Orally via Gavage to Crl:CDBR VAF/Plus Presumed Pregnant Rats, 44556901, Dow Chemical Co. Midland, MI.
12. Hunter D. L., Marshall R. S., Padilla S. Automated instrument analysis of cholinesterase activity in tissues from carbamate-treated animals: A cautionary note. Toxicol. Methods. 7:1997;43-53.
13. Lotti M. Cholinesterase inhibition: Complexities in interpretation. Clin. Chem. 41:1995;1814-1818.
14. Ma T., Chambers J. E. A kinetic analysis of hepatic microsomal activation of parathion and chlorpyrifos in control and phenobarbital-treated rats. J. Biochem. Toxicol. 10:1995;63-68.
15. Maurissen J. Chlorpyrifos: Assessment for developmental neurotoxicity in rats (report of an op assessed using proposed EPA test guidelines). Pesticides and Susceptible Populations: Who Is a Risk and When. 1998.
16. Maxwell D. M. Detoxication of organophosphorus compounds by carboxylesterase. Organophosphates. 1992a;Academic Press, San Diego. p. 183-199.
17. Maxwell D. M. The specificity of carboxylesterase protection against the toxicity of organophosphorus compounds. Toxicol. Appl. Pharmacol. 114:1992b;306-312.
18. Mortensen S. R., Brimijoin S., Hooper M. J., Padilla S. Comparison of the in vitro sensitivity of rat acetylcholinesterase to chlorpyrifos-oxon: What do tissue IC50 values represent? Toxicol. Appl. Pharmacol. 148:1998;46-49.
19. Moser V. C. Age- and gender-related differences in the time course of behavioral and biochemical effects produced by oral chlorpyrifos in rats. Toxicol. Appl. Pharmacol. 149:1998;107-119.
20. Nolan R. J., Rick D. L., Freshour N. L., Saunders J. H. Chlorpyrifos: pharmacokinetics in human volunteers. Toxicol. Appl. Pharmacol. 73:1984;8-15.
21. Nostrandt A. C., Padilla S., Moser V. C. The relationship of oral chlorpyrifos effects on behavior, cholinesterase inhibition, and muscarinic receptor density in rats. Pharmacol., Biochem. Behav. 58:1997;15-23.
22. NRC, 1993, Pesticides in the Diets of Infants and Children, N. R. Council, National Academy of Science Press, Washington, DC.
23. Padilla S. The neurotoxicity of cholinesterase-inhibiting insecticides: Past and present evidence demonstrating persistent effects. Inhalation Toxicol. 7:1995a;903-907.
24. Padilla S. Regulatory and research issues related to cholinesterase inhibition. Toxicology. 102:1995b;215-220.
25. Padilla S., Moser V. C., Pope C. N., Brimijoin W. S. Paraoxon toxicity is not potentiated by prior reduction in blood acetylcholinesterase. Toxicol. Appl. Pharmacol. 117:1992;110-115.
26. Pond A. L., Coyne C. P., Chambers H. W., Chambers J. E. Identification and isolation of two rat serum proteins with A-esterase activity toward paraoxon and chlorpyrifos-oxon. Biochem. Pharmacol. 52:1996;363-369.
27. Pope C. N., Chakraborti T. K., Chapman M. L., Farrar J. D., Arthun D. Comparison of in vivo cholinesterase inhibition in neonatal and adult rats by three organophosphorothioate insecticides. Toxicology. 68:1991;51-61.
28. Pope C. N., Liu J. Age-related differences in sensitivity to organophosphorus pesticides. Environ. Toxicol. Pharmacol. 4:1997;309-314.
29. SAP, 1997, Report of the Scientific Advisory Panel Meeting, EPA, Arlington, VA.
30. SAP, 1998, Fungicide and Rodenticide Act, EPA, Arlington, VA.
31. Sultatos L. G. Metabolic activation of the organophosphorus insecticides chlorpyrifos and fenitrothion by perfused rat liver. Toxicology. 68:1991;1-9.
32. Sultatos L. G., Minor L. D., Murphy S. D. Metabolic activation of phosphorothioate pesticides: Role of the liver. J. Pharmacol. Exp. Ther. 232:1985.
33. Sun Y.-P. Correlation of toxicity of insecticides to the house fly and to the mouse. J. Econ. Entomol. 65:1972;632-635.
34. Taylor P. Anticholinesterase agents. Hardman J. G., Goodman A., Gilman, Limbred L. E. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 1996;161-176 McGraw-Hill, New York.
35. Wallace K. B. Species-selective toxicity of organophosphorus insecticides: A pharmacodynamic phenomenon. Chambers J. E. Organophosphates. 1992;79-105 Academic Press, San Diego.
36. WHO, 1990, Principles for the Toxicological Assessment of Pesticide Residues in Food, International Program on Chemical Safety, Geneva.