Synergy of growth factors during mobilization of peripheral blood precursor cells with recombinant human Flt3-ligand and granulocyte colony- stimulating factor in rabbits

Experimental Hematology

Volumn 27, Issue 1, 1999, Pages 155-161

  Pless, Miklos ^a   Wodnar Filipowicz, Aleksandra ^a   John, Linde ^a   Baldomero, Helen ^a   Lyman, Stewart D ^b   Nissen, Catherine ^a   Gratwohl, Alois ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b AMGEN INC   (United States)

Author keywords

Flt3 ligand; Granulocyte colony; In vivo synergy of G CSF and Flt3 ligand; Peripheral blood precursor cell mobilization; Stimulating factor (G CSF)

Indexed keywords

LIGAND; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT GROWTH FACTOR; RECOMBINANT STEM CELL FACTOR; TYROSINE KINASE RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BLOOD CELL COUNT; COLONY FORMING UNIT GM; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; DRUG SCREENING; FEMALE; MALE; NONHUMAN; PERIPHERAL BLOOD STEM CELL; PRIORITY JOURNAL; RABBIT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FEMALE; GRANULOCYTE COLONY-STIMULATING FACTOR; GRANULOCYTES; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKOCYTE COUNT; LEUKOCYTES; LIGANDS; MACROPHAGES; MALE; MEMBRANE PROTEINS; RABBITS; RECOMBINANT PROTEINS; STEM CELL FACTOR; STEM CELLS; TIME FACTORS;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0033050682     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(98)00022-8     Document Type: Article

References (36)

1. Armitage J.O. Bone marrow transplantation. N Engl J Med. 330:1994;827.
2. Gratwohl A., Hermans J., Baldomero H. Blood and marrow transplantation activity in Europe 1995. Bone Marrow Transplant. 19:1997;407.
3. Eaves C.J. Peripheral blood stem cells reach new heights. Blood. 82:1993;1957.
4. Bensinger W.I., Weaver C.H., Appelbaum F.R., Rowley S., Demirer T., Sanders J., Storb R., Buckner C.D. Transplantation of allogeneic peripheral blood stem cells mobilized by recombinant human granulocyte colony-stimulating factor. Blood. 85:1995;1655.
5. Korbling M., Przepiorka D., Hugh Y.O., Engel H., Van Besien K., Giralt S., Andersson B., Kleine H.D., Seong D., Deisseroth A.B., Andreeff M., Champlin R. Allogeneic blood stem cell transplantation for refractory leukemia and lymphoma. potential advantage of blood over marrow allografts Blood. 85:1995;1659.
6. Schmitz N., Dreger P., Suttorp M., Rohwedder E.B., Haferlach T., Löffler H., Hunter A., Russell N.H. Primary transplantation of allogeneic peripheral blood progenitor cells mobilized by filgrastim (granulocyte colony-stimulating factor). Blood. 85:1995;1666.
7. Anderlini P., Körbling M., Dale D., Gratwohl A., Schmitz N., Stroncek D., Howe C., Leitman S., Horotwitz M., Gluckman E., Rowley S., Przepiorka D., Champlin R. Allogeneic blood stem cell transplantation. Considerations for donors Blood. 90:1997;903.
8. Lyman S.D., James L., Vanden Bos T., de Vries P., Brasel K., Gliniak P., Hollingsworth L.T., Picha K.S., McKenna H.J., Splett R.R., Fletcher F.A., Maraskovsky E., Farrah T., Foxworthe D., Williams D.E., Beckmann M.P. Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor. a proliferative factor for primitive hematopoietic cells Cell. 75:1993;1157.
9. Lyman S.D., James L., Johnson L., Brasel K., de Vries P., Escobar S.S., Downey H., Splett R.R., Beckmann M.P., McKenna H.J. Cloning of the human homologue of the murine flt3 ligand. a growth factor for early hematopoietic progenitor cells Blood. 83:1994;2795.
10. Hannum C., Culpepper J., Campbell D., McClanahan T., Zurawski S., Bazan F., Kastelein R., Hudak S., Wagner J., Mattson J., Luh J., Duda G., Martina N., Peterson D., Menon S., Shanafelt A., Muench M., Kelner G., Namikawa R., Rennick D., Roncarolo M.G., Zlotnik A., Rosnet O., Dubreuil P., Birnbaum D., Lee F. Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of hematopoietic stem cells and is encoded by variant RNAs. Nature. 368:1994;643.
11. Petzer A.L., Hogge D.E., Landsdorp P.M., Reid D.S., Eaves C.J. Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium. Proc Natl Acad Sci USA. 93:1996;1470.
12. + bone marrow progenitor cells in vitro. Blood. 87:1996;1317.
13. + hematopoietic progenitor cells. Blood. 86:1995;3413.
14. Gabbianelli M., Pelosi E., Montesoro E., Valtieri M., Luchetti L., Samoggia P., Vitelli L., Barberi T., Testa U., Lyman S., Peschle C. Multi-level effects of flt3 ligand on human hematopoiesis. expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors Blood. 86:1995;1661.
15. Rasko J.E.J., Metcalf D., Rossner M.T., Begley C.G., Nicola N.A. The flt3/flk-2 ligand. receptor distribution and action on murine haematopoietic cell survival and proliferation Leukemia. 9:1995;2058.
16. Lyman S.D., Seaberg M., Hanna R., Zappone J., Brasel K., Abkowitz J.L., Prchal J.T., Shahidi N.T. Plasma/serum levels of flt3 ligand are low in normal individuals and highly elevated in patients with Fanconi anemia and acquired aplastic anemia. Blood. 86:1995;4091.
17. Wodnar-Filipowicz A., Lyman S.D., Gratwohl A., Tichelli A., Speck B., Nissen C. Flt3 ligand level reflects hematopoietic progenitor cell function in aplastic anemia and chemotherapy-induced bone marrow aplasia. Blood. 88:1996;4493.
18. Brasel K., McKenna H.J., Morrissey P.J., Charrier K., Morris A.E., Lee C.C., Williams D.E., Lyman S.D. Hematologic effects of flt3 ligand in vivo in mice. Blood. 88:1996;2004.
19. Pless M., Baldomero H., John L., Gratwohl A., Filipowicz-Wodnar A., Speck B. Advances in chemotherapy and bone marrow transplant. Abraham N.G., Shadduck R.K., Levine A.S., Takaku F. Molecular biology of hematopoiesis, vol. 3. 1993;375-384 Intercept, Basel.
20. Gratwohl A., Baldomero H., John L., Gimmi C., Pless M., Tichelli A., Nissen C., Filipowicz A., Speck B. Transplantation of G-CSF mobilized allogeneic peripheral blood stem cells in rabbits. Bone Marrow Transplant. 16:1995;63.
21. Gratwohl A., Baldomero H., John L., Tichelli A., Filipowicz A., Nissen C., Speck B. Peripheral blood precursor cell transplantation across a major histocompatibility barrier in rabbits. positive effects of a higher number of precursor cells? Acta Haematol. 95:1996;176.
22. Kabata J., Gratwohl A., Tichelli A., John L., Speck B. Hematologic values of New Zealand White rabbits determined by automated flow cytometry. Lab Anim Sci. 41:1991;613.
23. Brizzi M.F., Avanzi G.C., Pegoraro L. Hematopoietic growth factor receptors. Int J Cell Cloning. 9:1991;274.
24. Demetri G.D., Griffin J.D. Granulocyte colony-stimulating factor and its receptor. Blood. 78:1991;2791.
25. Nicola N.A. Hematopoietic cell growth factors and their receptors. Ann Rev Biochem. 58:1989;45.
26. + human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc Natl Acad Sci USA. 91:1994;459.
27. De Lapeyriere O., Naquet P., Planche J., Marchetto S., Rottapel R., Gambarelli D., Rosnet O., Birnbaum D. Expression of Flt3 tyrosine kinase receptor gene in mouse hematopoietic and nervous tissues. Differentiation. 58:1995;351.
28. + cell mobilization to blood in rhesus monkeys. Blood. 88:1996;642. [abstr].
29. Winton E.F., Bucur S.Z., Bray R.A., Toba K., Williams D.E., McClure H.M., Lyman S.D. The hematopoietic effects of recombinant human (rh) Flt3 ligand administered to non-human primates. Blood. 86(Suppl 1):1995;424. [abstr].
30. Brasel K., McKenna H.J., Charrier K., Morrissey P., Williams D.E., Lyman S.D. Synergistic effects in vivo of Flt3 ligand with GM- CSF or G-CSF in mobilization of colony forming cells in mice. Blood. 86:1995;499. [abstr].
31. Sudo Y., Shimazaki C., Ashihira E., Kikuta T., Hirai H., Sumikuma T., Yamgata N., Goto H., Inaba T., Fujita N., Nakagawa M. Synergistic effect of flt-3 ligand on the granulocyte colony-stimulating factor-induced mobilization of hematopoietic stem cells and progenitor cells into blood in mice. Blood. 89:1997;3186.
32. Hudak S., Hunte B., Culpepper J., Menon S., Hannum C., Thompson-Snipes L., Rennick D. Flt3/flk2 ligand promotes the growth of murine stem cells and the expansion of colony-forming cells and spleen colony forming units. Blood. 85:1995;2747.
33. Martin F.H., Suggs S.V., Langley K.E., Lu H.S., Ting J., Okino K.H., Morris C.F., McNiece I.K., Jacobsen F.W., Mendiaz E.A., Birkett N.C., Smith K.A., Johnson M., Parker V.P., Flores J.C., Patel A.C., Fisher E.F., Erjavec H.O., Herrera C.J., Wypych J., Sachdev R.K., Pope J.A., Leslie J., Wen D., Lin C., Cupples R.L., Zsebo K.M. Primary structure and functional expression of rat and human stem cell factor DNAs. Cell. 63:1990;203.
34. Lev S., Blechman J., Nishikawa S., Givol D., Yarden Y. Interspecies molecular chimeras of kit help define the binding site of the stem cell factor. Mol. Cell Biol. 13:1993;2224.
35. + cells. Blood. 82:1993;3600.
36. + cells expanded in vitro. Exp Hematol. 22:1994;1171.