Bicyclic [b]-heteroannelated pyridazine derivatives. Part 8. A structure-activity relationship study of the 6-aryltriazolo[4,3-b]pyridazine ligands of thebenzodiazepine receptor and its ω1 subunit

Acta Poloniae Pharmaceutica - Drug Research

Volumn 56, Issue 1, 1999, Pages 61-68

  Lange, Jerzy ^a   Karolak Wojciechowska, Janina ^b   Wejroch, Krystyna ^a   Rump, Sławomir ^c  

^a WARSAW UNIVERSITY OF TECHNOLOGY   (Poland)

^b LODZ UNIVERSITY OF TECHNOLOGY   (Poland)

^c MILITARY INSTITUTE OF HYGIENE AND EPIDEMIOLOGY   (Poland)

Author keywords

1 subunit; Benzodiazepine receptor; Molecular modeling; QSAR analysis; Quantum chemistry analysis; Triazolopyridazines

Indexed keywords

3 METHYL 6 (3 TRIFLUOROMETHYLPHENYL) 1,2,4 TRIAZOLO[4,3 B]PYRIDAZINE; BENZODIAZEPINE RECEPTOR; PARTIAL AGONIST; PYRIDAZINE DERIVATIVE; RECEPTOR SUBUNIT; ZOLPIDEM;

ARTICLE; MOLECULAR MODEL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEPTOR AFFINITY; RECEPTOR BINDING;

EID: 0033050513     PISSN: 00016837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Zhang W., Koehler K.F., Zhang P., Cook J.M.: Drug Des. Discov. 12, 193 (1995).
2. Albright J.D., Moran D.B., Wright W.B. Jr., Collins J.B., Beer B., Lippa A.S., Greenblatt E.N.: J. Med. Chem. 24, 592 (1981).
3. Squires R.F., Benson D.I., Braestrup C., Coupet J., Klepner C.A., Myers V., Beer B.: Pharmacol. Biochem. Behav. 10, 825 (1979).
4. Lippa A.S., Critchett D., Sano M.C., Klepner C.A., Greenblatt E.N., Coupet J., Beer B.: Pharmacol. Biochem. Behav. 10, 831 (1979).
5. Oakley N.R., Jones B.J., Straughan D.W.: Neuropharmacol. 23, 797 (1984).
6. Gardner C.R.: Drug Develop. Res. 12, 1 (1988).
7. Klepner C.A., Lippa A.S., Benson D.I., Sano M.C., Beer B.: Pharmacol. Biochem. Behav. 11, 457 (1979).
8. Sieghart W., Karobath M.: Nature 286, 285 (1980).
9. Young W.S., Niehoff D., Kuhar M.J., Beer B., Lippa A.S.: J. Pharmacol. Exp. Ther. 216, 434 (1981).
10. Pritchett D.B., Lüddens H., Seeburg P.H.: Sience 245, 1389 (1989).
11. Doble A., Martin I.L.: Trens Pharmacol. Sci. 13, 76 (1992).
12. Wafford K.A., Whiting P.J., Kemp J.A.: Mol. Pharmacol. 43, 240 (1993).
13. Lange J., Karolak-Wojciechowska J., Gniewosz M., Plenkiewicz J.: Pharmazie 49, 21 (1994).
14. Lange J., Karolak-Wojciechowska J., Pytlewska E., Plenkiewicz J., Kuliński T., Rump S.: J. Heterocycl. Chem. 34, 389 (1997).
15. Lange J., Wejroch K., Karolak-Wojciechowska J., Plenkiewicz J., Gniewosz M., Tondys H., Ruzikowski P., Rump S.: Acta Polon. Pharm. - Drug Res. 53, 431 (1996).
16. Lange J., Karolak-Wojciechowska J., Gniewosz M., Kuliński T., Plenkiewicz J.: Acta Polon. Pharm. - Drug Res. 54, 299 (1997).
17. Tebib S., Bourguignon J.J., Wermuth C.G.: J. Comput. - Aided Mol. Des. 1, 153 (1987).
18. Biziére K., Bourguignon J.J., Chambon J.P., Heaulme M., Perio A., Tebib S., Wermuth C.G.: Brit. J. Pharmacol. 90, 183 (1987).
19. Boulanger T., Ledent L., Vercauteren D.P., Norberg B., Evrard G., Durant F.: Acta Cryst. C44, 1759 (1988).
20. Bertolasi V., Ferretti V., Gilli G., Borea P.A.: J. Chem. Soc., Perkin Trans 2 (1990), 283.
21. Karolak-Wojciechowska J., Lange J., Trzeźwińska H.B.: Pol. J. Chem. 71, 1012 (1997).
22. HyperChem 3.0 Program, Hypercube, Inc., Gainesville, FL, USA.
23. MOPAC 6 Program Packet, Quantum Chemistry Program Exchange, No. 326.
24. Kwiatkowski W., Karolak-Wojciechowska J.: SAR QSAR Envir. Res. 1, 233 (1993).
25. Villar H.O., Uyeno E.T., Toll L., Polgar W., Davies M.F., Loew G.H.: Mol. Pharmacol. 36, 589 (1989).
26. Karolak-Wojciechowska J., Lange J., Chuev I., Ruzikowski P.: HyperNews 2, 7 (1997).
27. Karolak-Wojciechowska J., Lange J., Kwiatkowski W., Gniewosz M., Plenkiewicz J.: Bioorg. Med. Chem. 2, 773 (1994).
28. Arbilla S., Allen J., Wick A., Langer S.Z.: Eur. J. Pharmacol. 130, 257 (1986).
29. Hansch C., Leo A.: Substituent Constants for Correlation Analysis in Chemistry and Biology, J. Wiley & Sons, New York, 1979.
30. Wu Y., Rosenberg H.C., Chiu T.H., Ramsey-Williams V.: J. Pharmacol. Exp. Ther. 268, 675 (1994).