Mutations of the MEN1 tumor suppressor gene in sporadic pituitary tumors

Cancer Letters

Volumn 142, Issue 1, 1999, Pages 43-47

  Wenbin, Chen ^a   Asai, Akio ^a   Teramoto, Akira ^b   Sanno, Naoko ^b   Kirino, Takaaki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

MEN1; Single stranded conformation polymorphism; Sporadic pituitary adenomas

Indexed keywords

SINGLE STRANDED DNA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; HYPOPHYSIS TUMOR; MALE; MULTIPLE ENDOCRINE NEOPLASIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOMATIC MUTATION; TUMOR SUPPRESSOR GENE;

ADENOMA; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; FEMALE; GENES, TUMOR SUPPRESSOR; HUMANS; MALE; MIDDLE AGED; MUTATION; NEOPLASM PROTEINS; PITUITARY NEOPLASMS; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROTO-ONCOGENE PROTEINS;

EID: 0033050421     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(99)00111-1     Document Type: Article

References (21)

1. Ezzat S., Melmed S. Pituitary tumors in the elderly. Morleyand J.E., Korenman S.G. Endocrinology and Metabolism in the Elderly. 1991;58-69 Blackwell Scientific Publications, Boston.
2. Alexander J.M., Biller B.M.K., Bikkal H., Zervas N.T., Amold A., Klibanski A. Clinically nonfunctioning pituitary tumors are monoclonal in origin. J. Clin. Invest. 86:1990;336-340.
3. Herman V., Fagin J., Gonsky R., Kovacs K., Melmed S. Clonal origin of pituitary adenomas. J. Clin. Endocrinol. Metab. 71:1990;1427-1433.
4. Vallar L., Spada V., Giannattasio G. Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas. Nature. 330:1987;566-568.
5. Karga H.J., Alexander J.M., Hedley-Whyte E.T., Kiibanski A., Jameson J.L. Ras mutation in human pituitary tumors. J. Clin. Endocrinol. Metab. 74:1992;914-919.
6. Pei L., Melmed S., Scheithauer B., Kovac K., Prager D. H-ras mutations in human pituitary carcinoma metastases. J. Clin. Endocrinol. Metab. 78:1994;842-846.
7. Cai W.Y., Alexander J.M., Hedley-Whyte E.T., Scheithauer B.W., Jameson J.L., Zervas N.T., Klibanski A. Ras mutations in human prolactinomas and pituitary carcinoma. J. Clin. Endocrinol. Metab. 78:1994;89-93.
8. Alvaro V., Levy L., Dubray C., Roche A., Peillon F., Querat B., Joubert D. Invasive human pituitary tumors express a point-mutated protein kinase-C. J. Clin. Endocrinol. Metab. 77:1993;1125-1129.
9. Sumi T., Stefaneanu L., Kovacs K., Asa S.L., Rindi G. Immunohistochemical study of p53 protein in human and animal pituitary tumors. Endocrinol. Pathol. 4:1993;95-99.
10. Cryns V.L., Alexander J.M., Klibanski A., Arnold A. The retinoblastoma gene in human pituitary tumors. J. Clin. Endocrinol. Metab. 77:1993;644-646.
11. Zhu J., Leon S.P., Beggs A.H., Busque L., Gillil D.G., Black P.M. Human pituitary adenomas show no loss of heterozygosity at the retinoblastoma gene locus. J. Clin. Endocrinol. Metab. 78:1994;922-927.
12. Yoshimoto K., Tanaka C., Yamada S., Kimura T., Iwahana H., Sano T., Itakura C. Infrequent mutations of p16 and p15 genes in human pituitary adenomas. Eur. J. Endocrinol. 136:1997;74-80.
13. Chandrasekharappa S.C., Guru S.C., Manickam P., Olufemi S.E., Collins F.S., Emmert-Buck M.R., Debelenko L.V., Zhuang Z., Lubensky I.A., Liotta L.A., Crabtree J.S., Wang Y., Roe B.A., Weisemann J., Boguski M.S., Agarwal S.K., Kester M.B., Kim Y.S., Heppner C., Dong Q., Spiegel A.M., Burns A.L., Marx S.J. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science. 276:1997;404-407.
14. Boggild M.D., Jenkinson S., Pistorello M., Boscaro M., Scanarini M., McTeman P., Perrett C.W., Thakker R.V., Clayton R.N. Molecular genetic studies of sporadic pituitary tumors. J. Clin. Endocrinol. Metab. 78:1994;387-392.
15. Lahiri D.K., Nurnberger J.I. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res. 19:1991;5444.
16. Zhuang Z., Vortmeyer A.O., Pack S., Huang S., Pham T., Wang C., Park W.S., Agarwal S., Debelenko L.V., Kester M.B., Guru S., Manickam P., Olufemi S.E., Yu F., Heppner C., Crabtree J., Skarulis M., Venzon D.J., Emmert-Buck M.R., Spiegel A.M., Chandrasekharappa S.C., Collins F.S., Burns A.L., Marx S.J., Jensen R.T., Liotta L.A., Lubensky I.A. Somatic mutations of the MEN 1 tumor suppressor gene in sporadic gastrinomas and insulinomas. Cancer Res. 57:1997;4682-4686.
17. Orita M., Iwahana H., Kanazawa H., Hayashi K., Sekiya T. Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc. Natl. Acad. Sci. USA. 86:1989;2766-2770.
18. Zhuang Z., Ezzat S.Z., Vortmeyer A.O., Weil R., Oldfield E.H., Park W.S., Pack S., Huang S., Agarwal S.K., Guru S.C., Manickam P., Debelenko L.V., Kester M.B., Olufemi S.E., Heppner C., Crabtree J.S., Burns A.L., Spiegel A.M., Marx S.J., Chandrasekharappa S.C., Collins F.S., Emmert-Buck M.R., Liotta L.A., Asa S.L., Lubensky I.A. Mutations of the MEN1 tumor suppressor gene in pituitary tumors. Cancer Res. 57:1997;5446-5451.
19. Prezant T.R., Levine J., Melmed S. Molecular characterization of the MEN1 tumor suppressor gene in sporadic pituitary tumors. J. Clin. Endocrinol. Metab. 83:1998;1388-1391.
20. Heppner C., Kester M., Agarwal S.K., Debelenko L.V., Emmert-Buck M.R., Guru S.C., Manickam P., Olufemi S.E., Skarulis S.E., Doppman J.L., Alexander R.H., Kim Y.S., Saggar S.K., Lubensky I.A., Zhuang Z., Liotta L.A., Chandrasekharappa S.C., Collins F.S., Spiegel A.M., Burns A.L., Marx S.J. Somatic mutation of the MEN1 gene in parathyroid tumours. Nat. Genet. 16:1997;375-378.
21. Guru S.C., Goldsmith P.K., Burns A.L., Marx S.J., Spiegel A.M., Collins F.S., Chandrasekharappa S.C. Menin, the product of the MEN1 gene, is a nuclear protein. Proc. Natl. Acad. Sci. USA. 95:1998;1630-1634.