메뉴 건너뛰기




Volumn 276, Issue 5 39-5, 1999, Pages

Effect of liver disease and transplantation on urea synthesis in humans: Relationship to acid-base status

Author keywords

Acid base metabolism; Ammonia; Base excess; Cirrhosis; Metabolic alkalosis

Indexed keywords

AMMONIA; BICARBONATE; LEUCINE; NITROGEN 15; UREA;

EID: 0033049387     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1999.276.5.g1145     Document Type: Article
Times cited : (48)

References (46)
  • 1
    • 0023179221 scopus 로고
    • Metabolic aspects of the regulation of systemic pH
    • Renal Fluid Electrolyte Physiol. 21
    • Atkinson, D. E., and E. Bourke. Metabolic aspects of the regulation of systemic pH. Am. J. Physiol. 252 (Renal Fluid Electrolyte Physiol. 21): F947-F956, 1987.
    • (1987) Am. J. Physiol. , vol.252
    • Atkinson, D.E.1    Bourke, E.2
  • 2
    • 0021234848 scopus 로고
    • Regulation of the rate of urea synthesis in liver by extracellular pH: A major factor in pH homeostasis in mammals
    • Bean, E. S., and D. E. Atkinson. Regulation of the rate of urea synthesis in liver by extracellular pH: a major factor in pH homeostasis in mammals. J. Biol. Chem. 259: 1552-1559, 1984.
    • (1984) J. Biol. Chem. , vol.259 , pp. 1552-1559
    • Bean, E.S.1    Atkinson, D.E.2
  • 3
    • 0021164583 scopus 로고
    • Reduced glomerular filtration and enhanced bicarbonate reabsorption in the maintenance of metabolic alkalosis in humans
    • Berger, B. E., M. G. Cogan, and A. Sebastian. Reduced glomerular filtration and enhanced bicarbonate reabsorption in the maintenance of metabolic alkalosis in humans. Kidney Int. 26: 205-208, 1983.
    • (1983) Kidney Int. , vol.26 , pp. 205-208
    • Berger, B.E.1    Cogan, M.G.2    Sebastian, A.3
  • 4
    • 0028587176 scopus 로고
    • Acute acidosis inhibits liver amino acid transport: No primary role for the urea cycle in acid-base balance
    • Renal Fluid Electrolyte Physiol. 36
    • Boon, L., P. J. E. Blommaart, A. J. Meijer, W. H. Lamers, and A. C. Schoolwerth. Acute acidosis inhibits liver amino acid transport: no primary role for the urea cycle in acid-base balance. Am. J. Physiol. 267 (Renal Fluid Electrolyte Physiol. 36): F1015-F1020, 1994.
    • (1994) Am. J. Physiol. , vol.267
    • Boon, L.1    Blommaart, P.J.E.2    Meijer, A.J.3    Lamers, W.H.4    Schoolwerth, A.C.5
  • 5
    • 0024361730 scopus 로고
    • Postoperative energy requirements following large abdominal surgery interventions: Comparisons of measuring by indirect calorimetry with estimated values
    • Brandmair, W., and L. Lehr. Postoperative energy requirements following large abdominal surgery interventions: comparisons of measuring by indirect calorimetry with estimated values. Langenbecks Arch. Chir. 374: 138-145, 1989.
    • (1989) Langenbecks Arch. Chir. , vol.374 , pp. 138-145
    • Brandmair, W.1    Lehr, L.2
  • 7
    • 0025833395 scopus 로고
    • Roles of the liver and kidney in acid-base regulation and its disorders
    • Cohen, R. D. Roles of the liver and kidney in acid-base regulation and its disorders. Br. J. Anaesth. 67: 154-164, 1991.
    • (1991) Br. J. Anaesth. , vol.67 , pp. 154-164
    • Cohen, R.D.1
  • 8
    • 0025046036 scopus 로고
    • Preanalytical increase of ammonia in blood specimens from healthy subjects
    • Da Fonseca-Wollheim, F. Preanalytical increase of ammonia in blood specimens from healthy subjects. Clin. Chem. 36: 1483-1487, 1990.
    • (1990) Clin. Chem. , vol.36 , pp. 1483-1487
    • Da Fonseca-Wollheim, F.1
  • 10
    • 0029120716 scopus 로고
    • Correlation among ionized calcium, citrate, and total calcium levels during hepatic transplantation
    • Diaz, J., F. Acosta, P. Parrilla, T. Sansano, R. F. Contreras, F. S. Bueno, and P. Martinez. Correlation among ionized calcium, citrate, and total calcium levels during hepatic transplantation. Clin. Biochem. 28: 315-317, 1995.
    • (1995) Clin. Biochem. , vol.28 , pp. 315-317
    • Diaz, J.1    Acosta, F.2    Parrilla, P.3    Sansano, T.4    Contreras, R.F.5    Bueno, F.S.6    Martinez, P.7
  • 11
    • 0028126540 scopus 로고
    • Blood ammonia levels as early indicator of allograft viability in human orthotopic liver transplantation
    • Diaz, J., P. Martinez, F. Acosta, and P. Parrilla. Blood ammonia levels as early indicator of allograft viability in human orthotopic liver transplantation. Am. J. Gastroenterol. 89: 2283-2284, 1994.
    • (1994) Am. J. Gastroenterol. , vol.89 , pp. 2283-2284
    • Diaz, J.1    Martinez, P.2    Acosta, F.3    Parrilla, P.4
  • 12
    • 0014825251 scopus 로고
    • Contribution of protein to caloric expenditure following injury
    • Duke, J. H., S. B. Jorgensen, J. R. Broell, C. L. Long, and J. M. Kinney. Contribution of protein to caloric expenditure following injury. Surgery 68: 168-174, 1970.
    • (1970) Surgery , vol.68 , pp. 168-174
    • Duke, J.H.1    Jorgensen, S.B.2    Broell, J.R.3    Long, C.L.4    Kinney, J.M.5
  • 13
    • 0027252523 scopus 로고
    • Unresponsiveness of hepatic nitrogen metabolism to glucagon infusion in patients with cirrhosis: Dependence on liver cell failure
    • Fabbri, A., G. Marchesini, G. Bianchi, E. Bugianesi, L. Bortoluzzi, M. Zoli, and E. Pisi. Unresponsiveness of hepatic nitrogen metabolism to glucagon infusion in patients with cirrhosis: dependence on liver cell failure. Hepatology 18: 28-35, 1993.
    • (1993) Hepatology , vol.18 , pp. 28-35
    • Fabbri, A.1    Marchesini, G.2    Bianchi, G.3    Bugianesi, E.4    Bortoluzzi, L.5    Zoli, M.6    Pisi, E.7
  • 14
    • 0027390447 scopus 로고
    • Steward's quantitative acid-base chemistry: Applications in biology and medicine
    • Fencl, V., and D. E. Leith. Steward's quantitative acid-base chemistry: Applications in biology and medicine. Respir. Physiol. 91: 1-16, 1993.
    • (1993) Respir. Physiol. , vol.91 , pp. 1-16
    • Fencl, V.1    Leith, D.E.2
  • 15
    • 0026476264 scopus 로고
    • Serum proteins and acid-base equilibria: A followup
    • Figge, J., T. Mydosh, and V. Fencl. Serum proteins and acid-base equilibria: a followup. J. Lab. Clin. Med. 120: 713-719, 1992.
    • (1992) J. Lab. Clin. Med. , vol.120 , pp. 713-719
    • Figge, J.1    Mydosh, T.2    Fencl, V.3
  • 16
    • 0026611406 scopus 로고
    • 15N-ammonia in patients with cirrhosis: A three-compartmental analysis
    • 15N-ammonia in patients with cirrhosis: a three-compartmental analysis. Hepatology 16: 347-352, 1992.
    • (1992) Hepatology , vol.16 , pp. 347-352
    • Fujii, T.1    Kohno, M.2    Hirayama, C.3
  • 17
    • 0026164988 scopus 로고
    • Isotopic determination of organic keto-acid pentafluorobenzyl esters in biological fluids by negative chemical ionization gas chromatography/mass spectrometry
    • Hachey, D. L., B. W. Patterson, P. J. Reeds, and L. J. Elsas. Isotopic determination of organic keto-acid pentafluorobenzyl esters in biological fluids by negative chemical ionization gas chromatography/mass spectrometry. Anal. Chem. 63: 919-923, 1991.
    • (1991) Anal. Chem. , vol.63 , pp. 919-923
    • Hachey, D.L.1    Patterson, B.W.2    Reeds, P.J.3    Elsas, L.J.4
  • 18
    • 0022470509 scopus 로고
    • Is urea formation regulated primarily by acid-base balance in vivo?
    • Renal Fluid Electrolyte Physiol. 19
    • Halperin, M. L., C. B. Chen, S. Cheema-Dhadli, M. L. West, and R. L. Jungas. Is urea formation regulated primarily by acid-base balance in vivo? Am. J. Physiol. 250 (Renal Fluid Electrolyte Physiol. 19): F605-F612, 1986.
    • (1986) Am. J. Physiol. , vol.250
    • Halperin, M.L.1    Chen, C.B.2    Cheema-Dhadli, S.3    West, M.L.4    Jungas, R.L.5
  • 19
    • 0025140847 scopus 로고
    • Bradykinin attenuates glucagon-induced leucine oxidation in humans
    • Endocrinol. Metab. 22
    • Hartl, W. H., H. Miyoshi, F. Jahoor, S. Klein, D. Elahi, and R. R. Wolfe. Bradykinin attenuates glucagon-induced leucine oxidation in humans. Am. J. Physiol. 259 (Endocrinol. Metab. 22): E239-E245, 1990.
    • (1990) Am. J. Physiol. , vol.259
    • Hartl, W.H.1    Miyoshi, H.2    Jahoor, F.3    Klein, S.4    Elahi, D.5    Wolfe, R.R.6
  • 20
    • 0022398710 scopus 로고
    • -, pH and the activity of carbonic anhydrase
    • -, pH and the activity of carbonic anhydrase. Eur. J. Biochem. 152: 381-386, 1985.
    • (1985) Eur. J. Biochem. , vol.152 , pp. 381-386
    • Haussinger, D.1    Gerok, W.2
  • 21
    • 0025059046 scopus 로고
    • Ammonium and bicarbonate homeostasis in chronic liver disease
    • Haussinger, D., R. Steeb, and W. Gerok. Ammonium and bicarbonate homeostasis in chronic liver disease. Klin. Wochensehr. 68: 175-182, 1990.
    • (1990) Klin. Wochensehr. , vol.68 , pp. 175-182
    • Haussinger, D.1    Steeb, R.2    Gerok, W.3
  • 23
    • 0024443172 scopus 로고
    • Role of insulin and glucose oxidation in mediating the protein catabolism of burns and sepsis
    • Endocrinol. Metab. 20
    • Jahoor, F., R. E. Shangraw, H. Miyoshi, H. Wallfish, D. N. Herndon, and R. R. Wolfe. Role of insulin and glucose oxidation in mediating the protein catabolism of burns and sepsis. Am. J. Physiol. 257 (Endocrinol. Metab. 20): E323-E331, 1989.
    • (1989) Am. J. Physiol. , vol.257
    • Jahoor, F.1    Shangraw, R.E.2    Miyoshi, H.3    Wallfish, H.4    Herndon, D.N.5    Wolfe, R.R.6
  • 24
    • 0023194859 scopus 로고
    • Reassessment of primed constant-infusion tracer method to measure urea kinetics
    • Endocrinol. Metab. 15
    • Jahoor, F., and R. R. Wolfe. Reassessment of primed constant-infusion tracer method to measure urea kinetics. Am. J. Physiol. 252 (Endocrinol. Metab. 15): E557-E564, 1987.
    • (1987) Am. J. Physiol. , vol.252
    • Jahoor, F.1    Wolfe, R.R.2
  • 25
    • 0015324018 scopus 로고
    • Corticosteroid-induced changes in urea metabolism in patients with hepatocellular disease
    • Jones, E. A., G. D. Cain, and G. Dickinson. Corticosteroid-induced changes in urea metabolism in patients with hepatocellular disease. Gastroenterology 62: 612-617, 1972.
    • (1972) Gastroenterology , vol.62 , pp. 612-617
    • Jones, E.A.1    Cain, G.D.2    Dickinson, G.3
  • 26
    • 0021353968 scopus 로고
    • Dependence of gluconeogenesis, urea synthesis, and energy metabolism of hepatocytes on intracellular pH
    • Kashiwagura, T., C. J. Deutsch, J. Taylor, M. Erecinska, and D. F. Wilson. Dependence of gluconeogenesis, urea synthesis, and energy metabolism of hepatocytes on intracellular pH. J. Biol. Chem. 259: 237-243, 1984.
    • (1984) J. Biol. Chem. , vol.259 , pp. 237-243
    • Kashiwagura, T.1    Deutsch, C.J.2    Taylor, J.3    Erecinska, M.4    Wilson, D.F.5
  • 27
    • 0026518051 scopus 로고
    • Adaptation to a diet low in protein: Effect of complex carbohydrate upon urea kinetics in normal man
    • Langran, M., B. J. Moran, J. L. Murphy, and A. A. Jackson. Adaptation to a diet low in protein: effect of complex carbohydrate upon urea kinetics in normal man. Clin. Sci. (Colch.) 82: 191-198, 1992.
    • (1992) Clin. Sci. (Colch.) , vol.82 , pp. 191-198
    • Langran, M.1    Moran, B.J.2    Murphy, J.L.3    Jackson, A.A.4
  • 28
    • 0016222548 scopus 로고
    • Urea-cycle enzymes in normal liver and in patients with alcoholic hepatitis
    • Maier, K. P., B. Volk, G. Hoppe-Seyler, and W. Gerok. Urea-cycle enzymes in normal liver and in patients with alcoholic hepatitis. Eur. J. Clin. Invest. 4: 193-195, 1974.
    • (1974) Eur. J. Clin. Invest. , vol.4 , pp. 193-195
    • Maier, K.P.1    Volk, B.2    Hoppe-Seyler, G.3    Gerok, W.4
  • 30
    • 0030044356 scopus 로고    scopus 로고
    • Salvage of exogenous urea nitrogen enhances nitrogen balance in normal men consuming marginally inadequate protein diets
    • Meakins, T. S., and A. A. Jackson. Salvage of exogenous urea nitrogen enhances nitrogen balance in normal men consuming marginally inadequate protein diets. Clin. Sci. (Colch.) 90: 215-225, 1996.
    • (1996) Clin. Sci. (Colch.) , vol.90 , pp. 215-225
    • Meakins, T.S.1    Jackson, A.A.2
  • 31
    • 0025361955 scopus 로고
    • Nitrogen metabolism and ornithine cycle function
    • Meijer, A. J., W. H. Lamers, and R. A. F. M. Chamuleau. Nitrogen metabolism and ornithine cycle function. Physiol. Rev. 70: 701-748, 1990.
    • (1990) Physiol. Rev. , vol.70 , pp. 701-748
    • Meijer, A.J.1    Lamers, W.H.2    Chamuleau, R.A.F.M.3
  • 32
    • 0022338005 scopus 로고
    • In vivo measurements of leucine metabolism with stable isotopes in normal subjects and in those with cirrhosis fed conventional and branched chain amino acid-enriched diets
    • Millikan, W. J., J. M. Henderson, J. R. Galloway, W. D. Warren, D. E. Matthews, A. McGhee, and M. H. Kutner. In vivo measurements of leucine metabolism with stable isotopes in normal subjects and in those with cirrhosis fed conventional and branched chain amino acid-enriched diets. Surgery 98: 405-412, 1985.
    • (1985) Surgery , vol.98 , pp. 405-412
    • Millikan, W.J.1    Henderson, J.M.2    Galloway, J.R.3    Warren, W.D.4    Matthews, D.E.5    McGhee, A.6    Kutner, M.H.7
  • 34
    • 0345718986 scopus 로고
    • Plasma ammonia, and urea-N synthesis rates in human liver cirrhotics
    • edited by P. B. Soeters, J. H. P. Wilson, A. J. Meijer, and E. Holm. Amsterdam: Excerpta Medica
    • Muting, D., K. J. Paquet, P. Koussouris, and H. Wuzel. Plasma ammonia, and urea-N synthesis rates in human liver cirrhotics. In: Advances in Ammonia Metabolism and Hepatic Encephalopathy, edited by P. B. Soeters, J. H. P. Wilson, A. J. Meijer, and E. Holm. Amsterdam: Excerpta Medica, 1988, p. 91-98.
    • (1988) Advances in Ammonia Metabolism and Hepatic Encephalopathy , pp. 91-98
    • Muting, D.1    Paquet, K.J.2    Koussouris, P.3    Wuzel, H.4
  • 36
    • 0030800679 scopus 로고    scopus 로고
    • Oral glutamine challenge in cirrhotics pre-and post-liver transplantation: A psychomotor and analyzed EEG study
    • Oppong, K. N., H. Al-Mardini, M. Thick, and C. O. Record. Oral glutamine challenge in cirrhotics pre-and post-liver transplantation: a psychomotor and analyzed EEG study. Hepatology 26: 870-876, 1997.
    • (1997) Hepatology , vol.26 , pp. 870-876
    • Oppong, K.N.1    Al-Mardini, H.2    Thick, M.3    Record, C.O.4
  • 43
    • 0023583115 scopus 로고
    • Whole body leucine, phenylalanine, and tyrosine kinetics in end stage liver disease before and after hepatic transplantation
    • Shanbhogue, R. L. K., B. R. Bistrian, K. Lakshman, L. Crosby, S. Swenson, D. Wagner, R. L. Jenkins, and G. L. Blackburn. Whole body leucine, phenylalanine, and tyrosine kinetics in end stage liver disease before and after hepatic transplantation. Metabolism 11: 1047-1053, 1987.
    • (1987) Metabolism , vol.11 , pp. 1047-1053
    • Shanbhogue, R.L.K.1    Bistrian, B.R.2    Lakshman, K.3    Crosby, L.4    Swenson, S.5    Wagner, D.6    Jenkins, R.L.7    Blackburn, G.L.8
  • 44
    • 0028139290 scopus 로고
    • Amelioration of lactic acidosis with dichloroacetate during liver transplantation in humans
    • Shangraw, R. E., R. Winter, J. Hromco, S. T. Robinson, and E. J. Gallaher. Amelioration of lactic acidosis with dichloroacetate during liver transplantation in humans. Anesthesiology 81: 1127-1138, 1994.
    • (1994) Anesthesiology , vol.81 , pp. 1127-1138
    • Shangraw, R.E.1    Winter, R.2    Hromco, J.3    Robinson, S.T.4    Gallaher, E.J.5
  • 46
    • 0002343982 scopus 로고
    • Body acid-base state and its regulation
    • edited by T. C. Ruch and H. D. Patton. Philadelphia, PA: Saunders
    • Woodbury, J. W. Body acid-base state and its regulation. In: Physiology and Biophysics (20th ed.), edited by T. C. Ruch and H. D. Patton. Philadelphia, PA: Saunders, 1974, p. 480-524.
    • (1974) Physiology and Biophysics (20th Ed.) , pp. 480-524
    • Woodbury, J.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.