Gene cloning and sequencing of BmK AS and BmK AS-1, two novel neurotoxins from the scorpion Buthus martensi Karsch

Toxicon

Volumn 37, Issue 5, 1999, Pages 815-823

  Lan, Zheng Dao ^a   Dai, Li ^a,b   Zhuo, Xiao Liang ^c   Feng, Jun Cai ^b   Xu, Ke ^c   Chi, Cheng Wu ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b NANJING UNIVERSITY   (China)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DNA FRAGMENT; NEUROTOXIN; SCORPION VENOM;

AMINO ACID SEQUENCE; ARTICLE; DNA TRANSCRIPTION; GENE SEQUENCE; MOLECULAR CLONING; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RACE; RNA TRANSLATION;

3' UNTRANSLATED REGIONS; 5' UNTRANSLATED REGIONS; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOTTING, NORTHERN; CLONING, MOLECULAR; DNA PRIMERS; DNA, COMPLEMENTARY; MOLECULAR SEQUENCE DATA; NEUROTOXINS; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SCORPION VENOMS; SCORPIONS;

BUTHUS; MESOBUTHUS MARTENSII; SCORPIONES;

EID: 0033048818     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(98)00221-9     Document Type: Article

References (16)

1. El-Hayek R., Lokuta A.J., Arevalo C., Valdivia H.H. Peptide probe of ryanodine receptor function, imperatoxin A, a peptide from the venom of the scorpion Pandinus imperator, selectively activates skeletal-type ryanodine receptor isoforms. J. Biol. Chem. 270(48):1995;28696-28704.
2. Ji Y.H., Xu K., Kawano S., Hirayama Y., Hiraoka M., Kuniyasu A., Nakayama H. A new scorpion polypeptide enhances the binding of radiolabeled-ryanodine on ryanodine receptor in sarcoplasmic recticulum of rabbit skeletal muscle. Chin. Sci. Bull. 42:1997;147-151.
3. Ji Y.H., Liu Y., Xu K., Ohishi T., Mochizuki T., Hoshino M., Yanaihara N. Amino acid sequence of BmK AS, a novel polypeptide activator of ryanodine receptor on skeletal muscle. Chin. Sci. Bull. 42:1997;952-956.
4. 3H ]noradrenaline release from rat hippocampal slices Biomed. Res. 18:1997;257-260.
5. Ji, Y.H., Li, Y.J., Zhang, J.W., Song, B.L., Yamaki, T., Mochizuki, T., Hoshino, M., Yanaihara, N., 1998. Covalent structures of BmK AS and BmK AS-1, two novel bioactive polypeptides purified from Chinese scorpion Buthus martensi Karsch. Toxicon. 37 (3), 519 - 536.
6. Liu Y., Ren H.M., Ji Y.H., Ohishi T., Mochizuki T., Hoshino M., Yanaihara N. Purification and the partial amino acid sequence of a novel activator of ryanodine receptor (BmK AS-1) from mammalian skeletal muscle. Biomed. Res. 17(6):1996;451-455.
7. Loret E.P., Martin-Eauclaire M.F., Mansuelle P. An anti-insect toxin purified from the scorpion Androctonus australis Hector also acts on the α- and β-sited of the mammalian sodium channel: sequence and circular dichroism study. Biochemistry. 30:1991;633-640.
8. Morrissette J., Beurg M., Sukhareva M., Coronado R. Purification and characterization of ryanotoxin, a peptide with actions similar to those of ryanodine. Biophys. J. 71:1996;701-721.
9. 2+, caffeine, and adenine nucleotides. Mol. Pharmacol. 31:1987;232-238.
10. Sutko J.L., Kenyon J.L. Ryanodine: a modifier of sarcoplasmic reticulum calcium release in striated muscle. Fed. Proc. 44:1985;2984-2988.
11. Valdivia H., Coronado R. Inhibition of dihydropyridine-sensitive calcium channels by the plant alkaloid ryanodine. FEBS Lett. 244:1989;333-337.
12. 2+ release channel of sarcoplasmic reticulum by a novel scorpion venom. J. Biol. Chem. 266:1991;19135-19138.
13. 2+-release channel of skeletal and cardiac muscle. Proc. Natl. Acad. Sci. USA. 89:1992;12185-12189.
14. Xiong Y.-M., Ling M.-H., Wang D.-C., Chi C.-W. The cDNA and genomic DNA sequences of a mammalian neurotoxin from the scorpion Buthus martensii Karsch. Toxicon. 35:1997;1025-1031.
15. Xiong, Y.-M., Ling, M.-H., Lan, Z.-D., Wang, D.-C., Chi, C.-W., 1998. The cDNA sequence excitatory insect specific neurotoxin from the scorpion Buthus martensii Karsch. Toxicon. 37 (2), 335 - 341.
16. 2+ release channels/ryanodine receptors. FEBS Lett. 405:1997;385-389.