Death from pulmonary thromboembolism in severe obesity: Lack of association with established genetic and clinical risk factors

Virchows Archiv

Volumn 434, Issue 6, 1999, Pages 529-532

  Blaszyk, Hagen ^a   Wollan, Peter C ^a   Witkiewicz, Agnieszka K ^a   Björnsson, Johannes ^a  

^a MAYO CLINIC   (United States)

Author keywords

Autopsy; Factor V gene; Obesity; Pulmonary embolism; Sudden death

Indexed keywords

BLOOD CLOTTING FACTOR 5;

ACTIVATED PROTEIN C RESISTANCE; ADULT; AGED; ARTICLE; BODY MASS; FEMALE; GENETIC ANALYSIS; GENETIC RISK; HUMAN; HUMAN TISSUE; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MORBID OBESITY; NORMAL HUMAN; POINT MUTATION; PRIORITY JOURNAL; RISK FACTOR; SUDDEN DEATH;

ADULT; AGED; BODY MASS INDEX; CAUSE OF DEATH; FACTOR V; FEMALE; HUMANS; MALE; MIDDLE AGED; OBESITY, MORBID; PULMONARY EMBOLISM; RISK FACTORS;

EID: 0033048635     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004280050379     Document Type: Article

References (21)

1. 1. Anderson FA Jr, Wheeler HB (1995) Venous thromboembolism. Risk factors and prophylaxis. Clin Chest Med 16:235-251
2. 2. Ascari E, Siragusa S, Piovella F (1995) The epidemiology of deep vein thrombosis and pulmonary embolism. Haematologica 80 [Suppl 2]:36-41
3. 3. Ashwell M (1994) Obesity in men and women. Int J Obes Relat Metab Disord 18 [Suppl] 1:S1-7
4. 4. Baumgartner RN, Heymsfield SB, Roche AF (1995) Human body composition and the epidemiology of chronic disease. Obes Res 3:73-95
5. 5. Bertina RM (1997) Introduction: hypercoagulable states. Semin Hematol 34:167-170
6. 6. Bray GA (1992) Pathophysiology of obesity. Am J Clin Nutr 55 [Suppl 2]:488S-494S
7. 7. Bray GA (1996) Health hazards of obesity. Endocrinol Metab Clin North Am 25:907-919
8. 8. Dahlback B (1997) Resistance to activated protein C as risk factor for thrombosis: molecular mechanisms, laboratory investigation, and clinical management. Semin Hematol 34:217-234
9. 9. Dahlback B, Carlsson M, Svensson PJ (1993) Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 90:1004-1008
10. 10. Duflou J, Virmani R, Rabin I, Burke A, Farb A, Smialek J (1995) Sudden death as a result of heart disease in morbid obesity. Am Heart J 130:306-313
11. 11. Hodge AM, Zimmet PZ (1994) The epidemiology of obesity. Baillieres Clin Endocrinol Metab 8:577-599
12. 12. Jensen MD (1992) Research techniques for body composition assessment. J Am Diet Assoc 92:454-460
13. 13. Kassirer JP, Angell M (1998) Losing weight - an ill-fated New Year's resolution (editorial). N Engl J Med 338:52-54
14. 14. McPhee SJ (1996) Maximizing the benefits of autopsy for clinicians and families. What needs to be done. Arch Pathol Lab Med 120:743-748
15. 15. Morrell MT, Dunnill MS (1968) The post-mortem incidence of pulmonary embolism in a hospital population. Br J Surg 55:347-352
16. 16. Robinson TN (1993) Defining obesity in children and adolescents: clinical approaches. Crit Rev Food Sci Nutr 33:313-320
17. 17. Rosendaal FR (1997) Risk factors for venous thrombosis: prevalence, risk, and interaction. Semin Hematol 34:171-187
18. 18. Salzman EW, Hirsh J (1994) The epidemiology, pathogenesis, and natural history of venous thrombosis. In: Colman RW, Hirsh J, Marder VJ, Salzman EW (eds) Hemostasis and thrombosis: basic principles and clinical practice. Lippincott, Philadelphia, pp 1275-1296
19. 19. Shibata D (1994) Preparation of nucleic acids for archival material. In: Mullis KB, Ferré F, Gibbs RA (eds) The polymerase chain reaction. Birkhäuser, Boston, pp 47-54
20. 20. Sorensen TI (1995) The genetics of obesity. Metabolism 44 [Suppl 3]:4-6
21. 21. Wolf AM, Colditz GA (1996) Social and economic effects of body weight in the United States. Am J Clin Nutr 63 [Suppl 3]:466S-469S