Administration of low-dose aspirin to mothers with small for gestational age fetuses and abnormal umbilical doppler studies to increase birthweight: A randomised double-blind controlled trial

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 106, Issue 7, 1999, Pages 647-651

  McCowan, Lesley M E ^a   Harding, Jane ^a   Roberts, Alistair ^a   Barker, Sarah ^a   Ford, Cassandra ^a   Stewart, Alistair ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; THROMBOXANE B2;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEVICE; DOPPLER ECHOGRAPHY; DOUBLE BLIND PROCEDURE; FEMALE; FETUS GROWTH; HUMAN; LOW BIRTH WEIGHT; MAJOR CLINICAL STUDY; ORAL DRUG ADMINISTRATION; PRENATAL CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SMALL FOR DATE INFANT; ULTRASOUND SCANNER;

ADULT; ASPIRIN; BIRTH WEIGHT; DOUBLE-BLIND METHOD; FEMALE; FETAL GROWTH RETARDATION; HUMANS; PLATELET AGGREGATION INHIBITORS; PREGNANCY; THROMBOXANE B2; ULTRASONOGRAPHY, DOPPLER; UMBILICAL CORD;

EID: 0033048164     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.1999.tb08362.x     Document Type: Article

References (22)

1. Seeds JW, Peng T. Impaired growth and risk of fetal death: Is the tenth percentile the appropriate standard Am J Obstet Gynecol 1998; 178: 658–669.
2. Wallace IF, McCarton CM. Neurodevelopmental outcomes of the pre-mature small for gestational age infant through age 6. Clin Obstet Gynecol 1997; 40: 843–852.
3. Barker DJP. The long-term outcome of retarded fetal growth. Clin Obstet Gynecol 1997; 40 853–863.
4. Jogee M, Myatt L, Elder MG. Decreased prostacyclin production by placental cells in culture from pregnancies complicated by fetal growth retardation. Br J Obster Gynaecol 1983; 90: 247–250.
5. Dadak C, Kefalides A, Sinzinger H, Weber G. Reduced umbilical artery prostacyclin formation in complicated pregnancies. Am J Obstet Gynecol 1982; 144: 792–795.
6. Ylikorkala O, Makila U-M, Kaapa P, Viinikka L. Maternal ingestion of acetylsalicylic acid inhibits fetal and neonatal prostacyclin and thromboxane in humans. Am J Obstet Gynecol 1986; 155: 345–349.
7. CLASP. A randomised trial of low-dose aspirin for the prevention and treatment of preeclampsia among 9364 pregnant women. Lancet 1994; 343: 619–629.
8. Uzan S, Beaufils M, Breart G, Bazin B, Capitant C, Paris J. Prevention of fetal growth retardation with low-dose aspirin: Findings of the EPREDA trial. Lancet 1990; 335: 1552–1555.
9. Italian Study of Aspirin in Pregnancy. Low-dose aspirin in prevention and treatment of intrauterine growth retardation and pregnancyinduced hypertension. Lancet 1993; 341: 396–400.
10. Leitch H, Egarter C, Husslein P, Kaider A, Schemper M. A meta analysis of low-dose aspirin for the prevention of intrauterine growth retardation. Br J Obstet Gynaecol 1997; 104: 450–459.
11. Trudinger BJ, Cook CM, Thompson RS, Giles WB, Connelly A. Lowdose aspirin therapy improves fetal weight in umbilical placental insufficiency. Am J Obstet Gynaecol 1988; 159: 681–685.
12. Newnham JP, Godfrey M, Walters BJN, Phillips J, Evans SF. Lowdose aspirin for the treatment of fetal growth restriction: A randomized controlled trial. Aust NZ J Obstet Gynaecol 1995; 35: 370–374.
13. Benigni A, Gregorini G, Frusca T et al. Effect of low-dose aspirin on fetal and maternal generation of thromboxane by platelets in women at risk for pregnancy-induced hypertension. N Engl J Med 1989; 321: 357–362.
14. Ritter JM, Farquhar C, Rodin A, Thom MH. Low-dose aspirin treatment in late pregnancy differentially inhibits cyclooxygenase in maternal platelets. Prostaglandins 1987; 34: 717–723.
15. Trudinger BJ, Connelly AJ, Giles WB. The effects of prostacyclin and thromboxane analogue (U46619) on the fetal circulation and umbilical artery flow velocity waveform. J Dev Physiol 1989; 11: 179–184.
16. Campbell S, Beard RW, Nathanielsz PW, editors. Fetal growth. In: Fetal Physiology and Medicine. London : WB Saunders. 1976: 271–271.
17. Duggan PM, McCowan LME. Normal ranges for Doppler flow velocity waveforms from the maternal uterine and fetal umbilical arteries. Aust NZ J Obstet Gynaecol 1993; 33 139–141.
18. Patrono C, Ciabattoni G, Pinca E et al. Low-dose aspirin and inhibition of thromboxane B2 production in healthy subjects. Thromb Res 1980; 17: 317–327.
19. Guaran RL, Win P, Walstab J, Beischer NA. Update of growth percentiles for infants born in an Australian population. Aust NZ J Obstet Gynaecol 1994; 34: 39–50.
20. Ylikorkala O, Malala UM. Prostacyclin and thromboxane in gynecology and obstetrics. Am J Obstet Gynecol 1985; 152: 318–329.
21. Wallenburg HCS, Rotmans N. Enhanced reactivity of the platelet thromboxane pathway in normotensive and hypertensive pregnancies with insufficient fetal growth. Am J Obstet Gynecol 1982; 144: 323.
22. Sorem KA, Siler-Khodr TM. Placental prostanoid release in severe intrauterine growth retardation. Placenta 1995; 16: 503–515.