A convenient route to cyanoguanidines

Synthetic Communications

Volumn 29, Issue 10, 1999, Pages 1757-1766

  Novak, Lajos ^a   Hanania, Michel ^a   Kovács, Péter ^b   Kovács, Csilla Erika ^a   Kolonits, Pál ^a   Szántay, Csaba ^a,b  

^a BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

^b CTRL RES INSTITUTE FOR CHEMISTRY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

CIMETIDINE; DICYANODIAMIDE; GUANIDINE DERIVATIVE; N ALLYL N' CYANO N'' PHENYLGUANIDINE; PINACIDIL; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS; PRECURSOR; STRUCTURE ACTIVITY RELATION;

EID: 0033047969     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1080/00397919908086163     Document Type: Article

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12. 2 (50 ml) was added isothiocyanate 4 (33 mmol) and stirring was continued for 2 hours at room temperature. After evaporation of the solvent under reduced pressure, the residue was crystallised from hexane.
13. 3I (75 mmol) and the resulting mixture was stirred further for 1 hour at room temperature. Evaporation of the solvent and crystallisation of the residue afforded thioether 6.
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