Combined prenatal toxicity of 6-mercaptopurine riboside and hydroxyurea in mice

Teratogenesis Carcinogenesis and Mutagenesis

Volumn 19, Issue 3, 1999, Pages 223-232

  Platzek, Thomas ^a,c   Schwabe, Rudolf ^b  

^a Fed Inst Hlth Protect C   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c Bundesinstitut Gesundheitlichen V   (Germany)

Author keywords

6 mercaptopurine riboside; DNA incorporation; Dose response; Hydroxyurea; Mice; Teratogenicity

Indexed keywords

DNA; HYDROXYUREA; MERCAPTOPURINE RIBOSIDE; SULFUR 35;

ANIMAL MODEL; ARTICLE; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DNA SYNTHESIS; EMBRYO; EMBRYOTOXICITY; FETUS; FETUS MALFORMATION; INTRAPERITONEAL DRUG ADMINISTRATION; ISOTOPE LABELING; MOUSE; NONHUMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; TERATOGENICITY;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYDROXYUREA; LIMB DEFORMITIES, CONGENITAL; MATERNAL-FETAL EXCHANGE; MICE; PREGNANCY; SKULL; TERATOGENS; THIOGUANINE; THIOINOSINE;

ANIMALIA; RODENTIA;

EID: 0033046947     PISSN: 02703211     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-6866(1999)19:3<223::AID-TCM5>3.0.CO;2-C     Document Type: Article

References (30)

1. Lennard L. The clinical pharmacology of 6-mercaptopurine. Eur J Clin Pharmacol 1992;43:329-339.
2. Ling Y-H, Chan JY, Beattie KL, Nelson JA. Consequences of 6-thioguanine incorporation into DNA on polymerase, ligase, and endonuclease reactions. Mol Pharmacol 1992;42:802-807.
3. Uribe-Luna S, Quintana-Hau JD, Maldonado-Rodriguez R, Espinosa-Lara M, Beattie KL, Farquhar D, Nelson JA. Mutagenic consequences of the incorporation of 6-thioguanine into DNA. Biochem Pharmacol 1997;54:419-424.
4. Thiersch JB. Effect of 6-mercaptopurine on the rat fetus and reproduction in the rat. Ann NY Acad Sci 1954;60:220-227.
5. Chaube S, Murphy ML. The effects of hydroxyurea and related compounds on the rat fetus. Cancer Res 1966;26:1448-1457.
6. Neubert D, Lessmöllmann U, Hinz N, Dillmann I, Fuchs G. Interference of 6-mercaptopurine riboside, 6-methylmercaptopurine riboside and azathioprine with the morphogenetic differentiation of mouse extremities in vivo and in organ culture. Naunyn-Schmiedeberg Arch Pharmacol 1977;298:93-105.
7. Platzek T, Schwabe R, Rahm U, Bochert B. DNA modification induced by 6-mercaptopurine riboside in murine embryos. Chem Biol Interact 1994;93:59-71.
8. Scott WJ, Ritter EJ, Wilson JG. DNA synthesis inhibition and cell death associated with hydroxyurea teratogenesis in rat embryos. Dev Biol 1971;26:306-315.
9. Ritter EJ, Scott WJ, Wilson JG. Cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis. Teratology 1973;7:219-226.
10. Chahoud I, Kwasigroch TE. Controlled breeding of laboratory animals. In: Neubert D, Merker H-J, Kwasigroch TE. Methods in prenatal toxicology. Stuttgart: G Thieme; 1977. p 78-91.
11. Dawson AA. A note on the staining of the skeleton of cleared specimen with alizarin red S. Stain Technol 1926;1:123-124.
12. SAS Institute Inc., SAS/STAT User's Guide, release 6.03 edition. Cary, NC: SAS Institute, Inc.; 1988.
13. Platzek T, Bochert G. Dose-response relationship of teratogenicity and prenatal-toxic risk estimation of 6-mercaptopurine riboside in mice. Teratogen Carcinogen Mutagen 1996;16:169-181.
14. Chahoud I, Faqi AS. Atlas of external anomalies in rats. CD-ROM. Berlin: PR & C Agentur; 1997.
15. Wise LD, Beck SL, Beltrame D, Beyer BK, Chahoud I, Clark RL, Clark R, Druga AM, Feuston MH, Giuttin P, Henwood SM, Kimmel CA, Lindstrom P, Palmer AK, Petrere JA, Solomon HM, Yasuda M, York RG. Terminology of developmental abnormalities in common laboratory mammals (version 1). Teratology 1997;5:249-292.
16. Barr M, Beaudoin AR. An exploration of the role of HU injection time in fetal growth and teratogenesis in rats. Teratology 1981;24:163-167.
17. Wilson JG, Scott WJ, Ritter EJ, Fradkin R. Comparative distribution and embryotoxicity of hydroxyurea in pregnant rats and rhesus monkeys. Teratology 1975;11:169-178.
18. Beliles RP, Makris NG, Scott WJ. Consideration of pharmacokinetics and temporal sensitivity for hydroxyurea in relation to teratogenic potential. J Am Cell Toxicol 1991;10:269-278.
19. Neubert D, Bochert G, Platzek T, Chahoud I, Fischer B, Meister R. Dose-response relationships in prenatal toxicity. Congenit Anom 1987;27:275-302.
20. Bianchi V, Pontis E, Reichard P. Changes of deoxyribonucleoside triphosphate pools induced by HU and their relation to DNA synthesis. J Biol Chem 1986;261:16037-16042.
21. Collins A, Oates DJ. Hydroxyurea effects on deoxyribonucleotide pool sizes repair. Eur J Biochem 1987;169:299-305.
22. Hansen DK, Grafton TF, Cross DR, James SJ. Partial attenuation of hydroxyurea-induced embryotoxicity by deoxyribonucleotides in mouse and rat embryos treated in vitro. Toxicology In Vitro 1995;9:11-19.
23. Desesso JM. Amelioration of teratogenesis. I. Modification of hydroxyurea-induced teratogenesis by the antioxidant propyl gallate. Teratology 1981;24:19-35.
24. Rajewsky MF, Fabricius E, Hulser DF. Synchronisation in vivo: temporary inhibition of DNA synthesis in the rat embryo with hydroxyurea. Exp Cell Res 1971;66:489-492.
25. Chaube S, Murphy ML. Protective effect of deoxycytidylic acid (cdmp) on hydroxyurea-induced malformations in rats. Teratology 1973;7:79-88.
26. Skalko RG, Tucci SM, Eretto PA, Schoen FS. 5-Bromodeoxyuridine teratogenesis in the mouse: modulation by hydroxyurea. In: Neubert D, Merker H-J, Nau H, Langman J, editors. Role of pharmacokinetics in prenatal and perinatal toxicology. Stuttgart: G Thieme; 1978. p 549-573.
27. Kwasigroch TE, Skalko RG. The teratogenic interaction of HU and BUDR examined with the aid of limb culture and image analysis. Fund Appl Toxicol 1985;5:1161-1173.
28. Ritter RJ, Scott WJ, Wilson JG, Mathinos PR, Randall JI. Potentiative interactions between caffeine and various teratogenic agents. Teratology 1982;25:95-100.
29. Ritter EJ. Potentiation of teratogenesis. Fundam Appl Toxicol 1984;4:352-359.
30. Nelson BK. Interactions in developmental toxicology: a literature review and terminology proposal. Teratology 1994;49:33-71.