Determination of TA-0201, a novel orally active non-peptide endothelin antagonist, in rat plasma and tissues by a liquid chromatography-electrospray ionization-tandem mass spectrometry system

Journal of Pharmaceutical and Biomedical Analysis

Volumn 19, Issue 3-4, 1999, Pages 491-499

  Ohashi, Noriko ^a   Nakamura, Susumu ^a   Yoshikawa, Masayoshi ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Collision induced dissociation; Electrospray; Endothelin receptor antagonist; Liquid chromatography tandem mass spectrometry; Plasma and tissue concentrations; Selected reaction monitoring; TA 0201

Indexed keywords

ENDOTHELIN RECEPTOR ANTAGONIST; N [6 [2 (5 BROMO 2 PYRIMIDINYLOXY)ETHOXY] 5 (4 METHYLPHENYL) 4 PYRIMIDINYL] 4 (2 HYDROXY 1,1 DIMETHYLETHYL)BENZENESULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG BLOOD LEVEL; DRUG TISSUE LEVEL; HEART; IONIZATION; KIDNEY; LIQUID CHROMATOGRAPHY; LUNG; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; STANDARD; TANDEM MASS SPECTROMETRY; TARGET ORGAN;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; CALIBRATION; CHROMATOGRAPHY, LIQUID; ENDOTHELINS; KIDNEY; LUNG; MALE; MASS SPECTROMETRY; MYOCARDIUM; ORGAN SPECIFICITY; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; SULFONAMIDES; TISSUE DISTRIBUTION;

EID: 0033046518     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(98)00244-1     Document Type: Article

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