Serum leptin levels in males with delayed puberty during short-term pulsatile GnRH administration

Journal of Endocrinological Investigation

Volumn 22, Issue 1, 1999, Pages 6-11

  Giusti, Massimo ^a   Guido, R ^b   Valenti, S ^b   Giordano, G ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b NONE

Author keywords

Delayed puberty; Leptin; Males; Pulsatile GnRH; Testosterone

Indexed keywords

FOLLITROPIN; GONADORELIN; GONADOTROPIN; LEPTIN; LUTEINIZING HORMONE; TESTOSTERONE;

ADOLESCENT; ARTICLE; BLOOD SAMPLING; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DELAYED PUBERTY; FOLLOW UP; HORMONE BLOOD LEVEL; HUMAN; HYPOGONADOTROPIC HYPOGONADISM; MALE; SUBCUTANEOUS DRUG ADMINISTRATION; TIME;

EID: 0033046380     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03345471     Document Type: Article

References (29)

1. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425, 1994.
2. Halaas J.L., Gajiwala K.S., Maffei M., Cohen S.L., Chait B.T., Robinowitz D., Lallone R.L., Burley S.K., Friedman J.M. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543, 1995.
3. Weigle D.S., Bukowski T.R., Foster D.C., Holderman S., Kramer J.M., Lesser G., Lofton D.C., Prunkard D.E., Raymond C., Kuijper J.L. Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J. Clin. Invest. 96: 2065, 1995.
4. Chehab F.F., Lim M.E., Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Gen. 12: 318, 1996.
5. Ahima R., Prabakaran D., Mantzoros C., Qu D., Lowell B., Maratos F.E., Flier J.S. Role of leptin in the neuroendocrine response to fasting. Nature 302: 250, 1996.
6. Barash I.A., Cheung C.C., Weigle D.S., Ren H., Kabigting E.B., Kuijper J.L, Clifton D.K., Steiner R.A. Leptin is a metabolic signal to the reproductive system. Endocrinology 137: 3144, 1996.
7. Ahima R., Dushay J., Flier S., Prabakaran D., Flier J. Leptin accelerates the timing of puberty in normal female mice. J. Clin. Invest. 99: 391, 1997.
8. Chehab F.F., Mounzih K., Lu R., Lim M.E. Early onset of reproductive function in normal female mice treated with leptin. Science 275: 88, 1997.
9. Apter D. Leptin in puberty. Clin. Endocrinol. (Oxf.) 47: 175, 1997.
10. Mantzoros C.S., Flier J.S., Rogol A.D. A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty. J. Clin. Endocrinol. Metab. 82: 1066, 1997.
11. Clayton P.E., Gill M.S., Hall C.M., Tillmann V., Whatmore A.J., Price D.A. Serum leptin through childhood and adolescence. Clin. Endocrinol. (Oxf.) 46: 727, 1997.
12. Blum W.F., Englaro P., Hanitsch S., Juul A, Hertel N.T., Muller J., Skakkebek N.E., Heiman M.L., Birkett M., Attanasio A.M., Kiess W., Rascher. W. Plasma leptin levels in healthy children and adolescent: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. J. Clin. Endocrinol. Metab. 82: 2904, 1997.
13. Garcia-Mayor R.V., Andrade M.A., Rios M., Lage M., Dieguez C., Casanueva F.F. Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones and pubertal stage. J. Clin. Endocrinol. Metab. 82: 2849, 1997.
14. Giusti M., Perfumo F., Verrina E., Cavallero D., Piaggio G., Valenti S., Gustnano R., Giordano G. Delayed puberty in uremia: pituitary-gonadal function during short-term pulsatile luteinizing hormone-releasing hormone administration. J. Endocrinol. Invest. 15: 709, 1992.
15. Spratt D.I., Finkelstein J.S., O'Dea L.S.L. Long-term administration of gonadotropin-releasing hormone in man with idiopathic hypogonadotropic hypogonadism: a model for studies of the hormone's physiological effects. Ann. Intern. Med. 105: 848, 1986.
16. Wagner T.O.F., Brabant G., Warsch F., Hesch R.D. Pulsatile gonadotropin-releasing hormone treatment in idiopathic delayed puberty. J. Clin. Endocrinol. Metab. 42: 942, 1986.
17. Tanner J.M. Growth at adolescence. Blackwell Scientific Publications, Oxford, 1962.
18. Behre H.M., Yeung C.H., Nieschlag E. Diagnosis of male Infertility and Hypogonadism. In: Nieschlag E., Behre H.M. (Eds.), Andrology Male Reproductive Health and Dysfunction. Springer, Berlin, 1997, p. 87.
19. Maffei M., Halaas J., Ravussin E., Pratley R.E., Lee G.H., Zhang Y., Fei H., Kim S., Lallone R., Ranganathan S., Kern P., Friedman J. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Med. 1: 1155, 1995.
20. Pombo M., Herrera-Justiniano E., Considine R.V., Hermida R.C., Galvez M.J., Martin T., Barreiro J., Casanueva F.F., Dieguez C. Nocturnal rise of leptin in normal prepubertal and pubertal children and in patients with perinatal stalk-transection syndrome. J. Clin. Endocrinol. Metab. 82: 2751, 1997.
21. Behre H.M., Simoni M., Nieschlag E. Strong association between serum levels of leptin and testosterone in men. Clin. Endocrinol. (Oxf.) 47: 237, 1997.
22. Jockenhovel F., Blum W.F., Vogel E., Englaro, P., Muller-Wieland D., Reinwein D., Rascher W., Krone W. Testosterone substitution normalizes elevated serum leptin levels in hypogonadal men. J. Clin. Endocrinol. Metab. 82: 2510, 1997.
23. Apter D., Butzow T.L., Laughlin G.A., Yen S.S.C. GnRH pulse generator activity during pubertal transition in girls: pulsatile and diurnal patterns of circulating gonadotropins. J. Clin. Endocrinol. Metab. 76: 940, 1993.
24. Wabithsch M., Blum W.F., Muche R., Braun M., Hube F., Rascher W., Heinze E., Teller W., Hauner H. Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J. Clin. Invest. 100: 808, 1997.
25. Rico H., Revilla M., Villa L.F., Hernandez E.R., Alvarez de Buergo M., Villa M. Body composition in children and Tanner's stages: a study with dual-energy r-ray absorptiometry. Metabolism 42: 967, 1993.
26. Florkowski C.M., Collier G.R., Zimmet P.Z., Livesey J.H., Espiner E.A., Donald R.A. Low-dose growth hormone replacement lowers plasma leptin and fat stores without effecting body mass index in adults with growth hormone deficiency. Clin. Endocrinol. (Oxf.) 45: 769, 1996.
27. Giustina A., Scalvini T., Tassi C., Desenzani P., Poiesi C., Wehrenberg W.B, Rogol A.D., Veldhuis J.D. Maturation of the regulation of growth hormone secretion in young males with hypogonadotropic hypogonadism pharmacologically exposed to progressive increments in serum testosterone. J. Clin. Endocrinol. Metab. 82: 1210, 1997.
28. Stanhope R., Pringle P.J., Brook C.G.D. The mechanism of the adolescent growth spurt induced by low dose pulsatile GnRH treatment. Clin. Endocrinol. (Oxf.) 28: 83, 1988.
29. Giusti M., Torre R., Cavagnaro P., Attanasio R., Traverse L., Giordano G. The effect of long-term pulsatile GnRH administration on the 24-hour integrated concentration of GH in hypogonadotropic hypogonadic patients. Acta Endocrinol. (Copenh.) 120: 724, 1989.