Increased splanchnic blood flow after hypoglycaemia in diabetic and normal man: Evidence against glucagon as a mediator

Clinical Science

Volumn 96, Issue 2, 1999, Pages 179-184

  Parker, D R ^a,b   Bargiota, A ^a   Braatvedt, G D ^a   Halliwell, M ^a   Corrall, R J M ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b WESTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Glucagon; Hypoglycaemia; Superior mesenteric artery blood flow

Indexed keywords

ADRENALIN; CATECHOLAMINE; GLUCAGON; GLUCOSE; GROWTH HORMONE; HUMAN INSULIN; HYDROCORTISONE;

ADULT; ARTERY BLOOD FLOW; ARTICLE; CATECHOLAMINE BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE DURATION; DOPPLER ECHOGRAPHY; GLUCAGON BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; HYPEREMIA; HYPOGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SPLANCHNIC BLOOD FLOW; SUPERIOR MESENTERIC ARTERY;

EID: 0033046364     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0960179     Document Type: Article

References (12)

1. 1 Braatvedt, G. D., Newrick, P. G., Halliwell, M. and Corrall, R. J. M. (1991) Splanchnic haemodynamic changes during hypoglycaemia in man. Clin. Sci. 81, 519-524
2. 2 Braatvedt, G. D., Flynn, M. D., Stanners, A., Halliwell, M. and Corrall, R. J. M. (1993) Splanchnic blood flow in man: evidence for mediation via a β-adrenergic mechanism. Clin. Sci. 84, 201-207
3. 3 Bolli, G., de Feo, P., Compagnucci, P. et al. (1983) Abnormal glucose counterregulation in insulin-dependent diabetes mellitus. Interaction of anti-insulin antibodies and impaired glucagon and epinephrine secretion. Diabetes 32, 134-141
4. 4 Liu, D., Moberg, E., Kollind, M., Lins, P.-E., Adamson, U. and Macdonald, I.A (1992) Arterial, arterialised venous and capillary blood glucose measurements in normal man during hyperinsulinaemic euglycaemia and hypoglycaemia. Diabetologia 35, 287-290
5. 5 Corrall, R. J. M., Frier, B. M., McClement, E. J. W., Taylor, S. J. and Christie, N. E. (1979) Recovery mechanisms from acute hypoglycaemia in complete tetraplegia. Eur. J. Clin. Invest. 17, 314-318
6. 6 Braatvedt, G. D., Stanners, A., Newrick, P. G., Halliwell, M. and Corrall, R. J. M. (1993) Evidence against a putative role for glucagon as a physiological splanchnic vasodilator in man. Clin. Sci. 84, 193-199
7. 7 Christensen, N.J. (1970) Abnormally high plasma catecholamines at rest and during exercise in ketotic juvenile diabetics. Scand. J. Clin. Lab. Invest. 26, 343-344
8. 8 Gerich, J. E., Davis, J., Lorenzi, M. et al. (1979) Hormonal mechanisms of recovery from insulin-induced hypoglycaemia in man. Am. J. Phys. 236, E380-E385
9. 9 Cryer, P. E. and Gerich, J. E. (1985) Glucose counterregulation, hypoglycemia and intensive insulin therapy in diabetes mellitus. N. Engl. J. Med. 313, 232-241
10. 10 Polonsky, K., Bergenstal, R., Pons, G., Schneider, M., Jaspan, J. and Rubenstein, A. (1982) Relation of counterregulatory responses to hypoglycaemia in Type 1 diabetics. N. Engl. J. Med. 307, 1106-1112
11. 11 Bolli, G. B., Dimitriadis, G. D., Pehling, G. B. et al. (1984) Abnormal glucose counterregulation after subcutaneous insulin in insulin-dependent diabetes mellitus. N. Engl. J. Med. 310, 1706-1711
12. 12 Clausen Sjobom, N., Adamson, U. and Lins, P.-E. (1989) The prevalence of impaired glucose counterregulation during an insulin-infusion test in insulin-treated diabetic patients prone to severe hypoglycaemia. Diabetologia 32, 818-825