Cannabinoid penetration into mouse brain as determined by ex vivo binding

European Journal of Pharmacology

Volumn 374, Issue 3, 1999, Pages 417-421

  Petitet, François ^a   Jeantaud, Bernadette ^a   Bertrand, Philippe ^a   Imperato, Assunta ^a  

^a CRVA   (France)

Author keywords

Cannabinoid penetration; Mouse brain

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR AGONIST; DRONABINOL; METHANANDAMIDE; RIMONABANT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; BRAIN HOMOGENATE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG BRAIN LEVEL; DRUG PENETRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ANIMALS; ARACHIDONIC ACIDS; BINDING, COMPETITIVE; BRAIN; CANNABINOIDS; CYCLOHEXANOLS; MALE; MICE; MORPHOLINES; NAPHTHALENES; PERFUSION; PIPERIDINES; PYRAZOLES; RADIOLIGAND ASSAY; RECEPTORS, DRUG; TRITIUM;

EID: 0033046130     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00189-2     Document Type: Article

References (18)

1. Baumgold J., Nikodijevic O., Jacobson K.A. Penetration of adenosine receptor antagonists into mouse brain as determined by ex vivo binding. Biochem. Pharmacol. 43:1992;889-894.
2. B/gastrin receptor antagonists. Eur. J. Pharmacol. 262:1994;233-245.
3. Devane W.A., Dysarz F.A., Johnson M.R., Melvin L.S., Howlett A.C. Determination and characterization of a cannabinoid receptor in rat brain. Mol. Pharmacol. 34:1988;605613.
4. Devane W.A., Hanus L., Breuer A., Pertwee R., Stevenson L.A., Griffin G., Gibson D., Mandelbaum A., Etinger A., Mechoulam R. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science. 258:1992;1946-1949.
5. Galiègue S., Mary S., Marchand J., Dussossoy D., Carrière D., Carayon P., Bouaboula M., Shire D., Le Fur G., Casellas P. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur. J. Biochem. 232:1995;54-61.
6. Gérard C.M., Mollereau C., Vassart G., Parmentier M. Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Biochem. J. 279:1991;129-134.
7. Herkenham M., Lynn A.B., Ross Johnson M., Melson L.S., de Costa B.R., Kenner C.R. Characterization and localization of cannabinoid receptor in rat brain: a quantitative in vitro autoradiographic study. J. Neurosci. 11:1991;563-583.
8. Hollister L.E. Health aspects of cannabis. Pharmacol. Rev. 38:1986;1-20.
9. Howlett A.C., Fleming R.M. Cannabinoid inhibition of adenylate cyclase. Pharmacology of the response in neuroblastoma cell membranes. Mol. Pharmacol. 26:1984;532-538.
10. Kuster J.E., Stevenson J.I., Ward S.J., D'Ambra T.E., Haycock D.A. Aminoalkylindole binding in rat cerebellum: selective displacement by natural and synthetic cannabinoids. J. Pharmacol. Exp. Ther. 264:1993;1352-1363.
11. Marshall F.H., Clark S.A., Michel A.D., Barnes J.C. Binding of angiotensin antagonists to rat liver and brain membranes measured ex vivo. Br. J. Pharmacol. 109:1993;760-764.
12. Martin B.R. Cellular effects of cannabinoids. Pharmacol. Rev. 38:1986;45-74.
13. Matsuda L.A., Lolait S.J., Brownstein M.J., Young A.C., Bonner T.I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature. 346:1990;561-564.
14. Matsuda L.A., Bonner T.I., Lolait S.J. Localization of cannabinoid receptor mRNA in rat brain. J. Comp. Neurol. 327:1993;535-550.
15. Munro S., Thomas K.L., Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature. 365:1993;61-65.
16. B receptor antagonists by ex vivo binding. Eur. J. Pharmacol. 253:1994;237-244.
17. Rinaldi-Carmona M., Barth F., Héaulme M., Shire D., Calandra B., Congy C., Martinez S., Maruani J., Néliat G., Caput D., Ferrara P., Soubrié P., Brelière J.-C., Le Fur G. SR 141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett. 350:1994;240-244.
18. 1 cannabinoid receptors in haemorrhagic shock. Nature. 390:1997;518-521.