Tetranucleotide repeats identify novel virulence determinant homologues in Neisseria meningitidis

Microbial Pathogenesis

Volumn 26, Issue 1, 1999, Pages 13-23

  Peak, Ian R A ^a,b   Jennings, Michael P ^b   Hood, Derek W ^a   Moxon, E Richard ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Neisseria meningitidis; Phase variation; Slipped strand mispairing; Tetranucleotide repeats; Virulence

Indexed keywords

ADHESIN; BACTERIUM LIPOPOLYSACCHARIDE; TETRANUCLEOTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL OUTER MEMBRANE; BACTERIAL VIRULENCE; BORDETELLA; ESCHERICHIA COLI; GENE LOCUS; HAEMOPHILUS INFLUENZAE; NEISSERIA GONORRHOEAE; NEISSERIA MENINGITIDIS; NONHUMAN; NUCLEOTIDE REPEAT; OPEN READING FRAME; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SHIGELLA FLEXNERI;

ANIMALIA; BACTERIA (MICROORGANISMS); BORDETELLA; ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; NEGIBACTERIA; NEISSERIA GONORRHOEAE; NEISSERIA MENINGITIDIS; PROKARYOTA; SHIGELLA FLEXNERI;

EID: 0033045773     PISSN: 08824010     EISSN: None     Source Type: Journal    
DOI: 10.1006/mpat.1998.0243     Document Type: Article

References (20)

1. Jonsson AB, Nyberg G, Normark S. Phase variation of gonococcal pili by frameshift mutation in pilC, a novel gene for pilus assembly. EMBO J 1991; 10: 477-88.
2. Moxon ER, Rainey PB, Nowak MA, Lenski RE. Adaptive evolution of highly mutable loci in pathogenic bacteria. Curr Biol 1994; 4: 24-33.
3. Jennings MP, Hood DW, Peak IR, Virji M, Moxon ER. Molecular analysis of a locus for the biosynthesis and phase-variable expression of the lacto-N-neotetraose terminal lipopolysaccharide structure in Neisseria meningitidis. Mol Microbiol 1995; 18: 729-40.
4. Jarosik GP, Hansen EJ. Identification of a new locus involved in expression of Haemophilus influenzae type b lipooligosaccharide. Infect Immun 1994; 62: 4861-7.
5. Weiser JN, Love JM, Moxon ER. The molecular mechanism of phase variation of H. Influenzae lipopolysaccharide. Cell 1989; 59: 657-65.
6. Hood DW, Deadman ME, Jennings MP, et al. DNA repeats identify novel virulence genes in Haemophilus influenzae. Proc Natl Acad Sci USA 1996; 93: 11121-5.
7. Peak IR, Jennings MP, Hood DW, Bisercic M, Moxon ER. Tetrameric repeat units associated with virulence factor phase variation in Haemophilus also occur in Neisseria spp. and Moraxella catarrhalis. FEMS Microbiol Lett 1996; 137: 109-14.
8. Roe BA, Lin SP, Song L, Yuan X, Clifton S, Dyer DW. http://www.genome.ou.edu/gono.html.
9. The Neisseria meningitidis Sequencing Group, ftp://ftp.sanger.ac.uk/pub/pathogens/nm/.
10. Jennings MP, Bisercic M, Dunn KL, et al. Cloning and molecular analysis of the lsi1 (rfaF) gene of Neisseria meningitidis which encodes a heptosyl-2-transferase involved in LPS biosynthesis: Evaluation of surface exposed carbohydrates in LPS mediated toxicity for human endothelial cells. Microb Pathog 1995; 19: 391-407.
11. Benz I, Schmidt MA. Diffuse adherence of enteropathogenic escherichia coli strains-processing of AIDA-I. Int J Med Microbiol Virol Parasitol Infect Dis 1993; 278: 197-208.
12. Bernardini ML, Mounier J, d'Hauteville H, Coquis RM, Sansonetti PJ. Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin. Proc Natl Acad Sci USA 1989; 86: 3867-71.
13. Li J, Fairweather NF, Novotny P, Dougan G, Charles IG. Cloning, nucleotide sequence and heterologous expression of the protective outer-membrane protein P.68 pertactin from bordetella bronchiseptica. J Gen Microbiol 1992; 138: 1697-705.
14. Suhr M, Benz I, Schmidt MA. Processing of the AIDA-I precursor: Removal of AIDAc and evidence for the outer membrane anchoring as a beta-barrel structure. Mol Microbiol 1996; 22: 31-42.
15. Suzuki T, Lett MC, Sasakawa C. Extracellular transport of VirG protein in Shigella. J Biol Chem 1995; 270: 30874-80.
16. JOse J, Jahnig F, Meyer TF. Common structural features of IgA1 protease-like outer membrane protein autotransporters. Mol Microbiol 1995; 18: 378-80.
17. Schirmer T, Cowan SW. Prediction of membrane-spanning β-strands and its application to maltoporin. Protein Sci 1993; 2: 1361-3.
18. Gibbs CP, Reimann BY, Schultz E, Kaufmann A, Haas R, Meyer TF. Reassortment of pilin genes in Neisseria gonorrhoeae occurs by two distinct mechanisms. Nature 1989; 338: 651-2.
19. Seiler A, Reinhardt R, Sarkari J, Caugant DA, Achtman M. Allelic polymorphism and site-specific recombination in the opc locus of Neisseria meningitidis. Mol Microbiol 1996; 19: 841-56.
20. Genetics Computer Group (1996), Madison, Wisconsin, U.S.A.