The effects of phenobarbital and ketoconazole on the alkaloid biosynthesis in Catharanthus roseus cell suspension cultures

Plant Physiology and Biochemistry

Volumn 37, Issue 2, 1999, Pages 139-144

  Contin, Adriana ^a   Collu, Graziella ^a   Van Der Heijden, Robert Der ^a   Verpoorte, Robert ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Alkaloids; Catharanthus roseus; Cytochrome 450; Geraniol 10 hydroxylase; Iridoids; Ketoconazole; Phenobarbital

Indexed keywords

CATHARANTHUS ROSEUS;

EID: 0033045549     PISSN: 09819428     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0981-9428(99)80075-8     Document Type: Article

References (23)

1. Ambike S.H., Baxter R.M., Zahid N.D., The relationship of cyt P-450 levels and alkaloid synthesis in Claviceps purpurea, Phytochemistry 9 (1970) 1953-1958.
2. Boland W., Oxidative bond cleavage reactions in nature; mechanistic and ecological aspects, Pure Appl. Chem. 65 (1993) 1133-1142.
3. Bradford M.M., A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem. 72 (1976) 248-254.
4. Burden R.S., Clark T., Holloway P.J., Effects of sterol biosynthesis-inhibiting fungicides and plant growth regulators on sterol composition of barley plants, Pestic. Biochem. Physiol. 27 (1987) 289-300.
5. Collu G., Bink H.H.J., Moreno P.R.H., van der Heijden R., Verpoorte R., Determination of the cytochrome P450 enzyme geraniol 10-hydroxylase by HPLC in plants, Phytochem. Anal. (1999) (in press).
6. Contin A., van der Heijden R., Lefeber A.W.M., Verpoorte R., The iridoid glucoside secologanin is derived from the novel triose phosphate/pyruvate pathway in a Catharanthus roseus cell culture, FEBS Lett. 434 (1998) 413-416.
7. Contin A., van der Heijden R., ten Hoopen H.J.G., Verpoorte R., The inoculum size triggers tryptamine or secologanin biosynthesis in a Catharanthus roseus cell culture, Plant Sci. (1999) (in press).
8. Dagnino D., Schripsema J., Verpoorte R., Analysis of several iridoid and indole precursors of terpenoid indole alkaloids with a single HPLC run, Planta Med. 62 (1996) 278-279.
9. Durst R, Benveniste L, Salaün J.-P., Werck-Reichhart D., Function and diversity of plant cytochrome P450, in: Lechner M.C. (Ed.), Cytochrome P450, Biochemistry, Biophysics and Molecular Biology, John Libbey Eurotext, Montrouge, 1994, pp. 23-30.
10. Gamborg O.L., Miller R.A., Ojima K., Nutrient requirements of suspension cultures of soybean root cells, Exp. Cell. Res. 50 (1968) 155-158.
11. Meijer A.H., Souer E., Verpoorte R., Hoge J.H.C., Isolation of cytochrome P-450 cDNA clones from the higher plant Catharanthus roseus by a PCR strategy, Plant Mol. Biol. 22 (1993) 379-383.
12. Moreno P.R.H., van der Heijden R., Verpoorte R., Effect of terpenoid precursor feeding and elicitation on formation of indole alkaloids in cell suspension cultures of Catharanthus roseus, Plant Cell. Rep. 12 (1993) 702-705.
13. Murashige T., Skoog F., A revised medium for rapid growth and bio-assays with tobacco tissue cultures, Physiol. Plant. 15 (1962) 473-497.
14. Partridge J.J., Chadha N.K., Faber S., Uskokovic M.R., Lead tetraacetate fragmentation of loganin aglucone O-methyl ether and its stereoisomers, Synth. Commun. 1 (1971) 233-240.
15. Reichhardt D., Salaün J.P., Benveniste I., Durst F., Induction by manganese, ethanol, phenobarbital and herbicides of microsomal cytochrome P-450 in higher plant tissues, Arch. Biochem. Biophys. 196 (1979) 301-303.
16. Reichhardt D., Salaün J.P., Benveniste I., Durst F., Time course of induction of cytochrome P-450, NADPH cytochrome c reductase, and cinnamic acid hydroxylase by phenobarbital, ethanol, herbicides, and manganese in higher plants microsomes, Plant Physiol. 66 (1980) 600-604.
17. Simpson A.P., Kelly S.L., Cytochrome P-450 inducer/ inhibitor effects on cell cultures of Catharanthus roseus, Plant Sci. 60 (1989) 231-236.
18. Tanahashi T., Nagakura N., Inouye H., Zenk M.H., Radioimmunoassay for the determination of loganin and the biotransformation of loganin to secologanin by plant cell cultures, Phytochemistry 23 (1984) 1917-1922.
19. Tietze L.F., Secologanin, a biogenetic key compound - Synthesis and biogenesis of the iridoid and secoiridoid glycosides, Angew. Chem. 22 (1983) 828-841.
20. Vanden Bossche H., Marichal P., Willensens G., Janssen P.A.J., Effects of inhibitors on the P450-dependent metabolism of endogenous compounds in fungi, protozoa, plants and vertebrates, in: Arinç E., Schenkman J.B., Hodgson E. (Eds.), Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds, Plenum Press, New York, 1991, pp. 345-363.
21. Van der Heijden R., Lamping P.J., Out P.P., Wijnsma R., Verpoorte R., High-performance liquid Chromatographic determination of indole alkaloids in a suspension culture of Tabernaemontana divaricata, J. Chromatogr. 396 (1987) 287-295.
22. Verpoorte R., van der Heijden R., Moreno P.R.H., Biosynthesis of terpenoid indole alkaloids in Catharanthus roseus cells, in: Cordell G.A. (Ed.), The Alkaloids, vol. 49, Academic Press, San Diego, 1997, pp. 221-299.
23. Waxman D.J., Azaroff L., Phenobarbital induction of cytochrome P-450 gene expression, Biochem. J. 28 (1992) 577-592.