A simple HPLC method for simultaneous determination of mycophenolic acid and mycophenolic acid glucuronide in plasma

Therapeutic Drug Monitoring

Volumn 21, Issue 3, 1999, Pages 322-324

  Svensson, Jan Olof ^a   Brattström, Christina ^a   Säwe, Juliette ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Mycophenolate mofetil; Mycophenolic acid; Mycophenolic acid glucuronide

Indexed keywords

ACETONITRILE; DRUG METABOLITE; GLUCURONIDE; MYCOPHENOLIC ACID;

ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STRUCTURE; HYDROLYSIS; PRECIPITATION; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUCURONATES; GLUCURONIDES; HUMANS; MOLECULAR STRUCTURE; MYCOPHENOLIC ACID; TIME FACTORS;

EID: 0033045129     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-199906000-00012     Document Type: Article

References (4)

1. Sugioka N, Odani H, Ohta T, Kishimoto H, Yasumura T, Takada K. Determination of a new immunosuppressant, mycophenolate mofetil, and its active metabolite, mycophenolic acid, in rat and human body fluids by high-performance liquid chromatography. J Chromatogr B 1994;654:249-56.
2. Haley CJ, Jaklitsch A, McGowan B, et al. Feasibility of an Emit assay for mycophenolic acid in plasma. Ther Drug Monit 1995; 17:432.
3. Tsina I, Chu F, Hama K, et al. Manual and automated (robotic high-performance liquid chromatography methods for the determination of mycophenolic acid and its glucuronide conjugate in human plasma. J Chromatogr B 1996;675:119-29
4. Huang JJ, Kiang H, Tarnowski TL. Simultaneous determination of mycophenolic acid and its glucuronide conjugate in human plasma by a single-run ion-pairing method. J Chromatogr B 1997;698: 293-300