Sublingual absorption of leuprolide: Comparison between human and animal models

International Journal of Pharmaceutics

Volumn 179, Issue 1, 1999, Pages 27-36

  Qiu, Yihong ^a   Johnson, Hillard W ^a   Reiland, Thomas L ^a   Fu Lu, Mou Ying ^a  

^a Formulation Development Center   (United States)

Author keywords

Animal model; Leuprolide; Pharmacokinetics; Sublingual absorption

Indexed keywords

LEUPRORELIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; HUMAN; INTRAVENOUS ADMINISTRATION; MONKEY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SUBLINGUAL DRUG ADMINISTRATION;

ADMINISTRATION, SUBLINGUAL; ADULT; ALGORITHMS; ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CROSS-OVER STUDIES; DOGS; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; LEUPROLIDE; MACACA FASCICULARIS;

EID: 0033044444     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(98)00359-7     Document Type: Article

References (17)

1. Adjei A., Doyle R., Pratt M., Finley R., Johnson E. Bioavailability of leuprolide following intratracheal administration to beagle dogs. Int. J. Pharm. 61:1990;135-144.
2. Adjei A., Love S., Johnson E., Diaz U., Greer J., Haviv F., Bush E. Effect of formulation adjuvants on gastrointestinal absorption of leuprolide acetate. J. Drug Targeting. 1:1993;251-258.
3. Chan R., Henzl M.R., LePage M.E., LaFargue J., Nerenberg C.A., Anik S., Chaplin M.D. Absorption and metabolism of nafarelin, a potent agonist of gonadotropin-releasing hormone. Clin. Pharmacol. Ther. 44:1988;275-282.
4. Cutler D. Linear system analysis in pharmacokinetics. J. Pharmacokin. Biopharm. 6:1978;265-282.
5. de Vries M.E., Bodde H.E., Verhoef J.C., Junginger H.E. Developments in buccal drug delivery. Crit. Rev. Ther. Drug Carrier Syst. 8(3):1991;271-303.
6. Fu Lu, M., Reiland, T., 1994. Compositions and method for the sublingual or buccal administration of therapeutic agents. US Patent 5284657.
7. Fu Lu M., Lee D., Rao G. S. Percutaneous absorption enhancement of leuprolide. Pharm. Res. 9(12):1992;1575-1579.
8. Gillespie W., Veng-Pedersen P. A polyexponentiai deconvolution method. evaluation of the 'gastrointestinal bioavallability' and mean in vivo dissolution time of some ibuprofen dosage forms, 3. Pharmacokin. Biopharm. 13:1985;289-307.
9. Lesch C.A., Squire C.A., Cruchley A., Williams D.M., Speight P. The permeability of human oral mucosa and skin to water. J. Dent. Res. 68(9):1989;1345-1349.
10. 1251-LHRH suitable for membrane binding studies. Proc. Soc. Exp. Biol. Med. 149:1975;351-355.
11. Okada H., Yamazaki I., Ogawa Y., Hiral S., Yashiki T., Mima H. Vaginal Absorption of a potent luteinizing hormone-releasing hormone analog (leuprolide) in rats, absorption by various routes and absorption enhancement. J. Pharm. Sci. 71:1982;1367-1371.
12. Squier C.A. The Permeability of oral mucosa. Crit. Rev. Oral Biol. Med. 2(1):1991;13-32.
13. Srinivasan V., Su M., Higuchi W.I., Behl C.R. Iontophoresis of polypeptides: effect of ethanol pretreatment of human skin. J. Pharm. Sci. 79:1990;588-591.
14. Sutherland J.W., Menon U.N. HPLC of leuprolide acetate in injectable solutions 3. Liq. Chromatogr. 10(10):1987;2281-2289.
15. Wagner J. G. Pharmacokinetics for the Pharmaceutical Scientist. 1993;83-85 Technomic Publishin, Lancaster, PA.
16. Zheng, Y., Fu Lu, M., Qiu, Y., Reiland, T., 1998a. Enzymatic degradation of peptide drugs in rat intestinal mucosa (in preparation).
17. Zheng, Y., Qiu, Y., Fu Lu, M., Reiland, T., 1998b. Permeability and absorption of leuprolide from different regions of intestines. Int. J. Pharm. (in review).